4.6 Article

Central Oxidative Stress and Early Vocational Outcomes in First Episode Psychosis: A 7-Tesla Magnetic Resonance Spectroscopy Study of Glutathione

期刊

SCHIZOPHRENIA BULLETIN
卷 -, 期 -, 页码 -

出版社

OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbac012

关键词

antioxidant; employment; schizophrenia; functioning; anterior cingulate

资金

  1. Canadian Institutes of Health Research Foundation [375104/2017]
  2. Academic Medical Organization of Southwestern Ontario (AMOSO) Opportunities fund
  3. Natural Science and Engineering Research Council of Canada [RGPIN2016-05055]
  4. Schulich School of Medicine and Dentistry Dean's Scholarship
  5. Parkwood Institute Studentship
  6. Canada First Excellence Research Fund
  7. Innovation fund for Academic Medical Organization of Southwest Ontario
  8. Bucke Family Fund
  9. Chrysalis Foundation
  10. Arcangelo Rea Family Foundation (London, Ontario)
  11. Compute Canada Resources for Research Groups Allocation
  12. Jonathan and Joshua Memorial Scholarship

向作者/读者索取更多资源

Patients with higher central antioxidant tone at first presentation of psychosis have better functional outcomes in early stages of illness, indicating a key role for central antioxidant tone in early psychosis.
Background and hypothesis Following the first episode of psychosis, some patients develop poor social and occupational outcomes, while others display a pattern of preserved functioning. Evidence from preclinical, genetic, and biochemical studies suggest a role for high oxidative stress in poor functional outcomes among patients. The measurement of intracortical glutathione (GSH) using magnetic resonance spectroscopy (MRS) enables investigating the relationship between central antioxidant tone and functional outcomes at the time of first-episode psychosis (FEP). We hypothesized that patients with higher central antioxidant tone at first presentation will have better functional outcomes in early stages of illness. Study design We scanned 57 patients with FEP and 30 matched healthy controls and estimated GSH resonance using 7-Tesla MRS. We minimized the confounding effects of illness chronicity, long-term treatment exposure, and metabolic complications by recruiting patients with Study results Patients who achieved employment/education or training status (EET) in the first year, had higher GSH at the baseline than healthy controls. Social and occupational functioning assessment scale (SOFAS) scores were also significantly higher in patients with higher GSH levels at the outset, after adjusting for various confounds including baseline SOFAS. Patients who were not in EET did not differ from healthy subjects in their GSH levels. Conclusion Our observations support a key role for the central antioxidant tone in the functional outcomes of early psychosis.

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