A molecular imprinted polymer on the surface of superparamagnetic Fe3O4-graphene oxide (MIP@Fe3O4@GO) for simultaneous recognition and enrichment of evodiamine and rutaecarpine in Evodiae fructus

A composite material (MIP@Fe3O4@GO) based on molecular imprinted polymer (MIP), superparamagnetic Fe3O4 particles and graphene oxide (GO) was prepared by the chemical coprecipitation method, and used to simultaneously separate and enrich two alkaloids (evodiamine and rutaecarpine) in the extract of Evodiae fructus. The as-prepared MIP@Fe3O4@GO was characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The adsorption kinetics, isotherms, competitive adsorption, and reusability of MIP@Fe3O4@GO were also investigated. The results revealed that MIP@Fe3O4@GO was sensitive to the magnetic field and could be easily separated using an external magnet; MIP@Fe3O4@GO showed good recognition selectivity, as well as simultaneous enrichment and separation abilities for evodiamine and rutaecarpine in the extract of E. fructus with satisfactory recoveries. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44465.