期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 95, 期 6, 页码 -出版社
WILEY
DOI: 10.1111/sji.13192
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资金
- National Institutes of Health [F30AI160909, R01AI130307, R01AR074105, T32AI007529, T32GM007753]
The germinal center serves as a crucial site for B cell selection and affinity maturation, with follicular T cells playing a key role in this process. Recent studies have elucidated the emerging roles of follicular T cells in autoimmune reactions and their potential therapeutic targets.
The germinal center serves as a site of B cell selection and affinity maturation, critical processes for productive adaptive immunity. In autoimmune disease tolerance is broken in the germinal center reaction, leading to production of autoreactive B cells that may propagate disease. Follicular T cells are crucial regulators of this process, providing signals necessary for B cell survival in the germinal center. Here, we review the emerging roles of follicular T cells in the autoreactive germinal center. Recent advances in immunological techniques have allowed study of the gene expression profiles and repertoire of follicular T cells at unprecedented resolution. These studies provide insight into the potential role follicular T cells play in preventing or facilitating germinal center loss of tolerance. Improved understanding of the mechanisms of T cell help in autoreactive germinal centers provides novel therapeutic targets for diseases of germinal center dysfunction.
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