Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patients

Article Infectious Diseases

Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection

Bo Diao et al.

Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Virology

Dynamics of IgG-avidity and antibody levels after Covid-19

Emma Lofstrom et al.

Summary: In this study, the maturation of IgG avidity and antibody levels over time in patients with PCR-confirmed non-severe Covid-19 was investigated. The results showed a significant increase in total n-antibodies from 1 to 3 months post-infection, followed by a significant decrease from 3 to 6 months. Meanwhile, a decrease in IgG anti-spike levels and an increase in IgG-avidity index were observed, suggesting a potential aspect of long-term immunity post Covid-19.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Article Veterinary Sciences

SARS-CoV-2 Infection in Dogs and Cats: Facts and Speculations

Nicola Decaro et al.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Microbiology

Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays

Emelissa J. Valcourt et al.

Summary: The study validated a SARS-CoV-2 PRNT and utilized it as a reference standard to evaluate various serological methods for measuring SARS-CoV-2 neutralizing antibodies, demonstrating excellent agreement with the reference-standard PRNT, including high-throughput platforms.

MICROBIOLOGY SPECTRUM (2021)

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Letter Immunology

Possible Human-to-Dog Transmission of SARS-CoV-2, Italy, 2020

Nicola Decaro et al.

Summary: This study identified severe acute respiratory syndrome coronavirus 2 in a healthy poodle living with 4 family members with coronavirus disease, with full-length genome sequencing showing the viruses were identical. The presence of antibodies in the dog's serum samples indicated seroconversion, suggesting possible human-to-animal transmission.

EMERGING INFECTIOUS DISEASES (2021)

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Article Virology

Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

Craig Fenwick et al.

Summary: In this study, antibody responses to SARS-CoV-2 were evaluated in acute and postinfection subjects. The results show that responses against viral S and N proteins were equally sensitive in acute phase, but N responses decreased in postinfection phase while S responses persisted. The most sensitive assay used the native S protein trimer, suggesting its importance in estimating SARS-CoV-2 infections and assessing vaccine-induced responses.

JOURNAL OF VIROLOGY (2021)

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Article Multidisciplinary Sciences