Why PGT-A, most likely, improves IVF success

Article Obstetrics & Gynecology

A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy

Ashley W. Tiegs et al.

Summary: The study aimed to determine the predictive value of PGT-A testing in forecasting the failure of successful delivery, finding high accuracy in predicting delivery failure with aneuploid results. Additionally, trophectoderm biopsy did not have a detectable adverse impact on sustained implantation.

FERTILITY AND STERILITY (2021)

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Article Genetics & Heredity

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial

Antonio Capalbo et al.

Summary: Research has shown that low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

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Article Genetics & Heredity

Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016-2018

Kathryn D. Sanders et al.

Summary: This study examined the outcomes of cycles with and without preimplantation genetic testing for aneuploidy (PGT-A) in the UK HFEA data collection. The results showed significantly higher live birth rates for cycles with PGT-A compared to those without PGT-A, across different age groups.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Obstetrics & Gynecology

Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use

Manuel Viotti et al.

Summary: This study investigated how the attributes of mosaicism identified during preimplantation genetic testing for aneuploidy are related to clinical outcomes, and formulated a ranking system for mosaic embryos. The results showed that euploid embryos had significantly better outcomes compared to mosaic embryos, with outcomes influenced by the level and type of mosaicism. Combining mosaic level, type, and embryo morphology revealed a ranking of subcategories regarding the likelihood of positive outcome.

FERTILITY AND STERILITY (2021)

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Article Medicine, General & Internal

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy

Junhao Yan et al.

Summary: In this randomized, controlled trial comparing PGT-A with conventional IVF in women with three or more good-quality blastocysts, it was found that the cumulative live-birth rate with conventional IVF was noninferior to that with PGT-A.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Obstetrics & Gynecology

Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction

Giovanni Coticchio et al.

Summary: Recent evidence from time-lapse technology and preimplantation genetic testing highlights the remarkable plasticity of human embryos in vitro, challenging current embryological notions and suggesting the need for new rules governing preimplantation development.

HUMAN REPRODUCTION UPDATE (2021)

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Article Cell Biology

Preimplantation Genetic Testing for Aneuploidy Improves Live Birth Rates with In Vitro Produced Bovine Embryos: A Blind Retrospective Study

Giuseppe Silvestri et al.

Summary: The study demonstrated that screening for aneuploid embryos using PGT-A can significantly improve pregnancy and live birth rates in cattle IVP programs. Analyzing 1713 cattle embryos revealed that aneuploid embryos have lower chances of establishing pregnancies and giving rise to live births compared to euploid embryos.

CELLS (2021)

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Article Obstetrics & Gynecology