期刊
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12958-022-00949-8
关键词
Betaine; Chronic restraint stress; Spermatogenic dysfunction; Oxidative stress
资金
- Natural Sciences Foundation of Hunan Province [2021JJ30593]
- Scientific Research Key Funding Project [19A428]
- Ministry of Education of China Hunan Foundation
This study investigates whether betaine has a therapeutic effect on sperm deformity and vitality under chronic restraint stress (CRS) and its mechanism. The results show that betaine injections can improve spermatogenesis dysfunction caused by CRS, which may provide potential dietary guidance.
Scope: Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active ingredient isolated from Lycium barbarum, has anti-oxidant, anti-inflammatory and other pharmacological activities. This study aims to explore whether betaine has a therapeutic effect on sperm deformity and vitality under CRS and its mechanism. Methods and results: Chronic restraint stress was induced in 8-week-old male C57BL/6 J mice by fixation for 6 h a day for 35 days. Mice were intraperitoneally injected with betaine (BET) or normal saline (NS) for 14 days. Thirty-five days later, the animals were sacrificed. The results showed that the detrimental effects of CRS on testes as evident by disrupted histoarchitecture, increased oxidative stress, inflammation and apoptosis that compromised male fertility. BET injections can reverse these symptoms. Conclusions: BET can improve spermatogenesis dysfunction caused by CRS, which may provide potential dietary guidance.
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