期刊
RECORDS OF NATURAL PRODUCTS
卷 16, 期 6, 页码 633-638出版社
ACG PUBLICATIONS
DOI: 10.25135/rnp.310.2110.2248
关键词
Aspergillus fumigatus; indole; alkaloid; antimicrobial; cytotoxic; alpha-glucosidase
资金
- Ministry of Science and Technology, Vietnam [HNQT/SPDP/11.19]
- Institute of Drug Research and Development, College of Pharmacy, Chungnam National University, Republic of Korea
A new compound and ten known compounds were isolated from marine-derived Aspergillus fumigatus M580. Compound 2, 3, and 7 showed significant antimicrobial activity against Gram-positive Enterococcus faecalis. Compound 4 exhibited significant cytotoxic activities against Huh7 and HT 29 cancer cell lines. Compound 3 and 10 showed the most alpha-glucosidase inhibitory activity.
One new indole glucoside, 6-methoxyindole-3-carboxylic acid O-beta-D-glucopyranosyl ester (1) and ten known alkaloids, fumiquinazoline D (2), fumiquinazoline C (3), fumiquinazoline J (4), bisdethiobis(methylthio)gliotoxin (5), cyclo(L-prolyl-L-tryptophane) (6), tryprostatin B (7), 12,13-dihydroxyfumitremorgin C (8), 6-methoxyspirotryprostatin B (9), cyclo(L-prolinyl-L-phenylalanine) (10), and cyclo(Lprolinyl-L-valine) (11) were isolated from marine-derived Aspergillus fumigatus M580. Compounds 2, 3, and 7 exhibited significant antimicrobial activity against Gram-positive Enterococcus faecalis with MIC values of 32, 32, and 64 mu g/mL, respectively. Compound 4 showed significant cytotoxic activities against Huh7 and HT 29 cancer cell lines with IC50 values of 9.7 +/- 0.9 and 10.3 +/- 0.9 mu M, respectively. Compounds 3 and 10 showed the most alpha-glucosidase inhibitory activity with inhibitory percentages of 13.6 +/- 1.1 and 10.3 +/- 0.8 % at the concentration of 100 mu g/mL, respectively.
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