期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 172, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2022.105205
关键词
Chitosan derivative; Chitosan acetate; alpha-Lipoic acid; Graft modification; Antioxidant activity
资金
- Natural Science Foun-dation of Shandong Province of China [ZR2019BD064]
- Youth Innova-tion Promotion Association CAS [2020219]
- National Key Research and Development Program of China [2019YFD0900705]
In this study, alpha-lipoic acid (LA) was successfully grafted onto chitosan to enhance antioxidant effect. The grafting ratio was controlled by adjusting reaction conditions, and it was found that higher grafting degree resulted in enhanced antioxidant activity. This study provides a novel synthesis strategy for the preparation of potential antioxidant biomaterials.
Here, alpha-lipoic acid (LA) was grafted onto chitosan via EDC/NHS to improve the antioxidant effect. Chitosan acetate was innovatively used as precursor replaced pristine chitosan to synthesize alpha-lipoic acid grafted chitosan derivatives with different grafting ratios. The grafting ratio of LA-g-CS conjugates could be controlled by adjusting the reaction temperature, reaction time, and feed ratio of alpha-lipoic acid to anhydroglucose unit, and the feed ratio is the main factor on the grafting efficiency. The antioxidant results (superoxide anion, hydroxyl, and DPPH radicals scavenging activities, and reducing power) indicated that LA-g-CS displayed significantly enhanced antioxidant activity over pristine chitosan. Moreover, antioxidant efficiency of LA-g-CS showed an ascending tendency with the increasing of the grafting degree. The present study provided a novel synthesis strategy for preparation of alpha-lipoic acid grafted chitosan derivatives that could be a potential antioxidant biomaterial in food and biomedical industries.
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