4.7 Review

Opportunities for Molecular Imaging in Multiple Sclerosis Management: Linking Probe to Treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

A phase 2 multicenter study of ublituximab, a novel glycoengineered anti-CD20 monoclonal antibody, in patients with relapsing forms of multiple sclerosis

Edward Fox et al.

Summary: The study demonstrated that Ublituximab is safe and effective in relapsing multiple sclerosis patients, leading to rapid depletion of B-cells and significant reductions in MRI activity and relapses.

MULTIPLE SCLEROSIS JOURNAL (2021)

Article Neurosciences

Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis

Leina B. Saito et al.

Summary: The study reveals the caspase-1 dependent interactions between inflammation, demyelination, and glucose metabolism in progressive MS and associated models. Inhibition of caspase-1 via intranasal delivery represents a promising therapeutic approach for progressive MS and other neuro-inflammatory diseases.
Article Clinical Neurology

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions

Mylyne Tham et al.

Summary: Research shows that the iron content and distribution in early active lesions differ among different MS immunopatterns, with immunopattern II lesions containing higher iron levels accumulated in macrophages compared to immunopattern III lesions. This heterogeneity may be due to different macrophage polarization, origin, or demyelination mechanisms. Developing iron-sensitive MRI techniques could potentially differentiate between immunopatterns in the MS patient population.

ANNALS OF NEUROLOGY (2021)

Article Medicine, General & Internal

In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination

Do-Wan Lee et al.

Summary: The study showed that cuprizone-induced demyelination in rats can significantly impact the metabolic changes in hippocampal lesions, possibly due to microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

DIAGNOSTICS (2021)

Article Multidisciplinary Sciences

Localisation of clozapine during experimental autoimmune encephalomyelitis and its impact on dopamine and its receptors

Katharina Robichon et al.

Summary: This study investigated the tissue distribution and localization of clozapine in the brain using mass spectrometry techniques and found that clozapine was enriched in specific brain regions and significantly elevated in serum during EAE. Additionally, changes in dopamine receptor expression on brain-resident and infiltrating immune cells during EAE were observed, providing insights into how neuroinflammation alters the distribution and downstream effects of clozapine.

SCIENTIFIC REPORTS (2021)

Review Immunology

Rituximab in Multiple Sclerosis: Are We Ready for Regulatory Approval?

Serena Brancati et al.

Summary: Rituximab has been shown to be a highly effective alternative in treating multiple sclerosis, with good effectiveness, safety, and patient compliance. Despite its off-label use in some countries, national regulatory authorities could officially recognize its usage through specific procedures to ensure equal access for patients to a safe and effective option.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy

Christian Prinz et al.

Summary: This study successfully demonstrated the feasibility of using F-19 MR methods to detect TF in vivo, showing a significant correlation between TF concentrations and F-19 MR signals. The results highlight the potential application of F-19 MR technology in monitoring neuro-inflammation, emphasizing the need for further technological advancements in this field.

THERANOSTICS (2021)

Article Clinical Neurology

Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging

Elena Herranz et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis

Bao Ying Chen et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

Article Clinical Neurology

Sensitivity of the Inhomogeneous Magnetization Transfer Imaging Technique to Spinal Cord Damage in Multiple Sclerosis

H. Rasoanandrianina et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis

Yeona Kang et al.

MOLECULAR IMAGING AND BIOLOGY (2020)

Article Physics, Multidisciplinary

Protocols for Dual Tracer PET/SPECT Preclinical Imaging

Julia E. Blower et al.

FRONTIERS IN PHYSICS (2020)

Article Immunology

Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis

Marc Y. Stevens et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

S. K. Vainio et al.

EJNMMI RESEARCH (2019)

Review Cell Biology

Nanomodulation of Macrophages in Multiple Sclerosis

Frances K. Nally et al.

Article Clinical Neurology

Natalizumab treatment reduces microglial activation in the white matter of the MS brain

Marcus Sucksdorff et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2019)

Article Clinical Neurology

Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a

Erin L. MacMillan et al.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T

Samantha By et al.

MAGNETIC RESONANCE IN MEDICINE (2018)

Article Clinical Neurology

Cerebral rituximab uptake in multiple sclerosis: A 89Zr-immunoPET pilot study

Marloes H. J. Hagens et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Clinical Neurology

Cerebral rituximab uptake in multiple sclerosis: A 89Zr-immunoPET pilot study

Marloes H. J. Hagens et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis

Tarun Singhal et al.

CLINICAL NUCLEAR MEDICINE (2018)

Article Clinical Neurology

Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells

Bryan Ceronie et al.

JOURNAL OF NEUROLOGY (2018)

Review Clinical Neurology

Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting

Carmen Tur et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Multidisciplinary Sciences

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Michael D. Kornberg et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Development of a PET radioligand for potassium channels to image CNS demyelination

Pedro Brugarolas et al.

SCIENTIFIC REPORTS (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Clinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations

Jeff W. M. Bulte et al.

RADIOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Imaging B Cells in a Mouse Model of Multiple Sclerosis Using 64Cu-Rituximab PET

Michelle L. James et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of the Effect of Fingolimod Treatment on Microglial Activation Using Serial PET Imaging in Multiple Sclerosis

Marcus Sucksdorff et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

Article Multidisciplinary Sciences

Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model

Caroline Guglielmetti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases

Md. Maqusood Alam et al.

NUCLEAR MEDICINE AND MOLECULAR IMAGING (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis

Abraham Martin et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2016)

Article Clinical Neurology

Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI

Philipp Eisele et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Article Clinical Neurology

Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI

Philipp Eisele et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Article Clinical Neurology

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

Benedetta Bodini et al.

ANNALS OF NEUROLOGY (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography

Eric Berg et al.

MEDICAL PHYSICS (2016)

Article Multidisciplinary Sciences

Heterogeneity of Multiple Sclerosis Lesions in Multislice Myelin Water Imaging

Tobias Djamsched Faizy et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

Simultaneous SPECT imaging of multi-targets to assist in identifying hepatic lesions

Zhide Guo et al.

SCIENTIFIC REPORTS (2016)

Article Pharmacology & Pharmacy

In Vivo Tissue Pharmacokinetics of Carbon-11-Labeled Clozapine in Healthy Volunteers: A Positron Emission Tomography Study

Hs Park et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

Amit Bar-Or et al.

Article Radiology, Nuclear Medicine & Medical Imaging

Altered serotonin transporter availability in patients with multiple sclerosis

Swen Hesse et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2014)

Article Clinical Neurology

Neuroprotection with glatiramer acetate: evidence from the PreCISe trial

Douglas L. Arnold et al.

JOURNAL OF NEUROLOGY (2013)

Article Neurosciences

Platelet serotonin in multiple sclerosis and its relationship with fatigue syndrome

T. V. Baidina et al.

NEUROCHEMICAL JOURNAL (2013)

Article Pharmacology & Pharmacy

Positron emission tomography molecular imaging for drug development

Paul M. Matthews et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)

Article Clinical Neurology

Decreased microglial activation in MS patients treated with glatiramer acetate

John N. Ratchford et al.

JOURNAL OF NEUROLOGY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG PET Detects Inflammatory Infiltrates in Spinal Cord Experimental Autoimmune Encephalomyelitis Lesions

Dorothea Buck et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Improvement in PET/CT Image Quality with a Combination of Point-Spread Function and Time-of-Flight in Relation to Reconstruction Parameters

Go Akamatsu et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Article Clinical Neurology

Inflammation inhibits GABA transmission in multiple sclerosis

Silvia Rossi et al.

MULTIPLE SCLEROSIS JOURNAL (2012)

Article Oncology

Mitoxantrone Inhibits HIF-1α Expression in a Topoisomerase II-Independent Pathway

Yng-Miin Toh et al.

CLINICAL CANCER RESEARCH (2011)

Article Biochemistry & Molecular Biology

VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis

Sebastien Serres et al.

FASEB JOURNAL (2011)

Review Biophysics

Fluorine (19F) MRS and MRI in biomedicine

Jesus Ruiz-Cabello et al.

NMR IN BIOMEDICINE (2011)

Article Clinical Neurology

I-123 MIBG cardiac scintigraphy and autonomic test evaluation in multiple sclerosis patients

Mordechai Lorberboym et al.

JOURNAL OF NEUROLOGY (2008)

Article Clinical Neurology

Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression

Ofira Einstein et al.

ANNALS OF NEUROLOGY (2007)

Article Radiology, Nuclear Medicine & Medical Imaging

Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice

Tamir Ben-Hur et al.

MAGNETIC RESONANCE IN MEDICINE (2007)

Article Engineering, Biomedical

Quantification in simultaneous 99mTc/123I brain SPECT using generalized spectral factor analysis:: a Monte Carlo study

Sebastien Hapdey et al.

PHYSICS IN MEDICINE AND BIOLOGY (2006)

Article Immunology

Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion

JW Rose et al.

JOURNAL OF NEUROIMMUNOLOGY (2004)

Article Radiology, Nuclear Medicine & Medical Imaging

MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

JWM Bulte et al.

MAGNETIC RESONANCE IN MEDICINE (2003)

Article Radiology, Nuclear Medicine & Medical Imaging

Serial 1H-MRS in relapsing-remitting multiple sclerosis:: effects of interferon-β therapy on absolute metabolite concentrations

F Schubert et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2002)

Article Immunology

ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging

DA Sipkins et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)