期刊
PURINERGIC SIGNALLING
卷 18, 期 2, 页码 193-198出版社
SPRINGER
DOI: 10.1007/s11302-022-09862-6
关键词
ATP; Adenosine; Ectoenzymes; CD73; Metabolism; Burnstock
资金
- German Research Council (DFG) [SFB1116, 236177352]
- Cardiovascular Research Institute Duesseldorf (CARID)
- Projekt DEAL
This article reviews Geoffrey Burnstock's personal achievements and his contributions to extracellular purine metabolism. The article also provides an overview of current research in this field and addresses some unresolved issues.
Historically, mainly by the work of Robert Berne, extracellular adenosine was the first purine compound recognized as an important signaling molecule linking energy metabolism to function by acting on membrane bound receptors. Geoffrey Burnstock by his vision and endurance pioneered the idea that cells release ATP that also acts as an extracellular signaling molecule under many physiological and pathophysiological circumstances. Only later, it was appreciated that extracellular ATP and adenosine are metabolically linked by the activity of several ectoenzymes which critically determine the concentrations of these purines at their respective receptors. In this brief review, I will report some personal recollections on Geoffrey Burnstock and his impressive personality. In addition, I will give a brief overview on our present knowledge of extracellular purine metabolism and its control and will address some still open issues.
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