Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins

Background A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality related to alcohol consumption. This will be done by estimating the risk for CVD mortality and all-cause mortality in twin pairs discordant for alcohol consumption. Methods Alcohol consumption was assessed at two time points using self-report questionnaires in the Norwegian Twin Registry. Data on CVD mortality was obtained from the Norwegian Cause of Death Registry. Exposure-outcome associations for all-cause mortality and mortality due to other causes than CVD were estimated for comparison. Results Coming from a family with moderate to high alcohol consumption was protective against cardiovascular death (HR = 0.54, 95% CI 0.65-0.83). Moderate and high alcohol consumption levels were associated with a slightly increased risk of CVD mortality at the individual level (HR = 1.33, 95% CI 1.02-1.73). There was no association between alcohol consumption and all-cause mortality both at the familial nor at the individual level. Conclusions The protective association of moderate to high alcohol consumption with a lower risk of CVD mortality was accounted for by familial factors in this study of twins. Early life genetic and environmental familial factors may mask an absence of health effect of moderate to high alcohol consumption on cardiovascular mortality.

Automated summary

Moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease mortality, but the mechanisms behind this association are still unclear. This study aimed to estimate the familial and individual risk for CVD mortality related to alcohol consumption by analyzing data from twin pairs. The results showed that familial factors accounted for the protective association of moderate to high alcohol consumption with a lower risk of CVD mortality. Early life genetic and environmental familial factors may mask any absence of health effects of moderate to high alcohol consumption on cardiovascular mortality.