期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 324, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2022.111490
关键词
Autism; Functional connectivity; Primary auditory cortex; Resting state functional magnetic resonance; imaging; Anterior cingulate cortex
资金
- NIH [U19 HD035482, MH066496, R21 MH079871, NIMH MH67924, HD55748, UL1RR024986]
- Autism Speaks
- Michigan Institute for Clinical and Health Research [KO1 NIMH MH081191]
- Autism Speaks [04593]
- National Science Foundation [EPS-0903787]
This study investigated the functional connectivity of the primary auditory cortex in individuals with Autism Spectrum Disorder (ASD). The results showed reduced connectivity between the auditory cortex and specific regions, such as the medial occipital cortex and primary motor cortex, in individuals with ASD compared to those without ASD. This reduced connectivity may contribute to deficient sensory integration associated with ASD.
Autism Spectrum Disorder (ASD) has been found to influence hearing and sensory integration, while brain functional connectivity in ASD has been repeatedly shown to be atypical. However, functional connectivity of the auditory cortex in ASD has not been well studied. In the current study, we used resting-state functional magnetic resonance imaging data, provided by the Autism Brain Imaging Data Exchange (ABIDE), to examine functional connectivity of the primary auditory cortex in ASD. The study subjects included 68 individuals with ASD and 77 individuals without ASD. In the primary dataset, the ASD group showed lesser functional connectivity between the auditory cortex and four regions: the medial occipital cortex, primary motor cortex, insular cortex, and Wernicke's area. In the replication dataset (44 individuals with ASD and 39 individuals without ASD), reduced connectivity to the medial occipital cortex and primary motor cortex was replicated among these four regions, which have previously been shown to be influenced by ASD. Thus, the reduced functional connectivity to these indicated regions may partly explain deficient sensory integration associated with ASD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据