期刊
PSYCHIATRY RESEARCH
卷 311, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2022.114474
关键词
Functional somatic disorders; Randomized controlled trials (RCTs); Antidepressants; Psychotherapy; Eligibility criteria; Patients' willingness to participate
类别
资金
- Danish foundation Trygfonden
This study compares two previous parallel running randomized controlled trials of pharmacotherapy and psychotherapy for multi-organ functional somatic disorder (FSD). The study reveals differences in patient characteristics and highlights potential flaws in trial design and interpretation of results.
This study retrospectively compares two previous parallel running, randomized, controlled trials of pharmacotherapy (imipramine) and psychotherapy (acceptance and commitment therapy) for multi-organ functional somatic disorder (FSD). Differences in demographics, psychiatric comorbidity, illness severity, and illness duration associated with eligibility for the two trials and patients' willingness to participate are explored using linear or binary regression models. 418 patients with multi-organ FSD was included. We found that 377 (95%) were eligible for psychotherapy and 257 patients (61%) for pharmacotherapy. Patients eligible for pharmacotherapy were less severely impaired, less often received disability pension, reported shorter illness duration and experienced less psychological distress than patients eligible for psychotherapy. Whilst exclusion criteria for both trials differed markedly, it was not possible to clearly identify patient or illness characteristics associated with patients' willingness to participate. The study showed that trial-specific exclusion criteria led to the selection of less complex and less severely impaired patients in the pharmacological trial in this sample of multi-organ FSD. Our findings have important implications for the interpretation and comparability of RCT results of different treatments in multi-organ FSD and may point to some common flaws in study design and interpretation of pharmacological vs. psychotherapeutic intervention trials in psychiatry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据