Spherical nucleic acids as an infectious disease vaccine platform

Article Urology & Nephrology

A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection

Luise Hassler et al.

Summary: This study demonstrates the preclinical efficacy of a novel soluble ACE2 protein in a lethal mouse model of SARS-CoV-2 infection, reducing lung and kidney injury.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Biochemistry & Molecular Biology

UniProt: the universal protein knowledgebase in 2021

Alex Bateman et al.

Summary: The UniProt Knowledgebase aims to provide users with a comprehensive, high-quality set of protein sequences annotated with functional information. Updates over the past two years have increased the number of sequences to approximately 190 million, with new methods to assess proteome completeness and quality. UniProtKB has responded to the COVID-19 pandemic by expertly curating relevant entries and making them rapidly available through a dedicated portal.

NUCLEIC ACIDS RESEARCH (2021)

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Article Multidisciplinary Sciences

Neutralizing antibody titres in SARS-CoV-2 infections

Eric H. Y. Lau et al.

Summary: In this study, researchers quantified SARS-CoV-2 specific neutralizing antibodies using plaque reduction neutralization (PRNT) assays on 195 patients in different disease states. They found that patients with severe disease had higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections, and that serum neutralizing antibody persists for over 6 months in most people.

NATURE COMMUNICATIONS (2021)

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News Item Multidisciplinary Sciences

HOW PROTEIN-BASED COVID VACCINES COULD CHANGE THE PANDEMIC

Elie Dolgin

NATURE (2021)

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Review Biochemistry & Molecular Biology

Vaccine development for emerging infectious diseases

Jean-Louis Excler et al.

Summary: Studies on COVID-19 vaccination strategies in comparison to previous infectious diseases offer critical lessons for future public health emergencies. The unprecedented scale and rapid spread of emerging infectious diseases present new challenges for vaccine development and distribution. Prioritizing access to vaccines in low- and middle-income countries, along with close monitoring of vaccine safety and virus variants, will be crucial for the success of pandemic control efforts.

NATURE MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Impact of Liposomal Spherical Nucleic Acid Structure on Immunotherapeutic Function

Cassandra E. Callmann et al.

Summary: Liposomal spherical nucleic acids (L-SNAs) have potential as cancer immunotherapeutics, with their biological properties and immunomodulatory activity influenced by liposome composition. Modulating L-SNAs by exchanging liposome components can provide a new approach for the rational design of nanoscale immunotherapeutics.

ACS CENTRAL SCIENCE (2021)

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Article Virology

Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice

Jesus A. Silvas et al.

Summary: The study identified ORF3a and ORF6 as major contributors to viral pathogenesis in SARS-CoV-2, while ORF7a, ORF7b, and ORF8 had little impact on disease outcome. Additionally, the use of a reverse-genetics system to generate recombinant SARS-CoV-2 constructs lays the foundation for developing live attenuated vaccines for the treatment of SARS-CoV-2.

JOURNAL OF VIROLOGY (2021)

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Article Biochemistry & Molecular Biology

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Joana Barros-Martins et al.

Summary: A study found that booster vaccination with BNT162b2 in healthcare professionals previously vaccinated with ChAdOx-1 nCoV-19 elicited more neutralizing antibodies and higher frequencies of virus-specific T cells. Additionally, BNT162b2 induced high titers of neutralizing antibodies against variants of concern, such as B.1.1.7, B.1.351, and P.1.

NATURE MEDICINE (2021)

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Article Engineering, Biomedical

Spherical Nucleic Acid Vaccine Structure Markedly Influences Adaptive Immune Responses of Clinically Utilized Prostate Cancer Targets

Michelle H. Teplensky et al.

Summary: The use of spherical nucleic acid vaccines demonstrates the importance of precise architectural control in activating robust antigen-specific immune responses for prostate cancer. This optimized structure can significantly enhance immune activation and cytolytic ability, leading to improved targeting and killing of cancer cells.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Multidisciplinary Sciences

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

Jian Zheng et al.

Summary: The COVID-19 pandemic is associated with significant morbidity and mortality. Experimental studies in animals infected with SARS-CoV-2 have revealed severe lung and brain damage, as well as early onset anosmia in mice. Excitingly, infusion of convalescent plasma from recovered patients has shown to protect against lethal disease, though it does not prevent anosmia.

NATURE (2021)

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Review Biotechnology & Applied Microbiology

Next-generation influenza vaccines: opportunities and challenges

Chih-Jen Wei et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Public, Environmental & Occupational Health

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection

Gregory Brett Moreau et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)

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Article Immunology

Development of Spherical Nucleic Acids for Prostate Cancer Immunotherapy

Lei Qin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer

Cassandra E. Callmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Immunology

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Emma S. Winkler et al.

NATURE IMMUNOLOGY (2020)

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Article Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

Jun Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

Joseph W. Golden et al.

JCI INSIGHT (2020)

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Article Engineering, Biomedical

Exploration of the nanomedicine-design space with high-throughput screening and machine learning

Gokay Yamankurt et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Review Immunology

Selection of adjuvants for vaccines targeting specific pathogens

Indranil Sarkar et al.

EXPERT REVIEW OF VACCINES (2019)

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Article Multidisciplinary Sciences

Rational vaccinology with spherical nucleic acids

Shuya Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Immunology

Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination

Anna-Karin E. Palm et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid-Tail DNA Modifications

Brian Meckes et al.

SMALL (2018)

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Review Biotechnology & Applied Microbiology

Adjuvanted influenza vaccines

John S. Tregoning et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Review Immunology

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

Harm HogenEsch et al.

NPJ VACCINES (2018)

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Review Biotechnology & Applied Microbiology

From discovery to licensure, the Adjuvant System story

Nathalie Garcon et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Article Multidisciplinary Sciences

Immunomodulatory spherical nucleic acids

Aleksandar F. Radovic-Moreno et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Chemistry, Multidisciplinary

Liposomal Spherical Nucleic Acids

Resham J. Banga et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Cell Biology

Emerging Viral Diseases: Confronting Threats with New Technologies

Hilary D. Marston et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Review Pharmacology & Pharmacy

Pharmacokinetic studies of protein drugs: Past, present and future

Eric Ezan

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Microbiology

Traditional and New Influenza Vaccines

Sook-San Wong et al.

CLINICAL MICROBIOLOGY REVIEWS (2013)

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Article Multidisciplinary Sciences

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Masaru Kanekiyo et al.

NATURE (2013)

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Review Biochemistry & Molecular Biology

Key roles of adjuvants in modern vaccines

Steven G. Reed et al.

NATURE MEDICINE (2013)

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Article Multidisciplinary Sciences

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

Chung Hang J. Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Microbiology

Emerging Infectious Diseases: Threats to Human Health and Global Stability

David M. Morens et al.

PLOS PATHOGENS (2013)

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Article Chemistry, Multidisciplinary

Spherical Nucleic Acids

Joshua I. Cutler et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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Review Biochemical Research Methods

Role of spectral counting in quantitative proteomics

Deborah H. Lundgren et al.

EXPERT REVIEW OF PROTEOMICS (2010)

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Article Allergy

Structure and function of immunoglobulins

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Chemistry, Multidisciplinary

Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids

Dwight S. Seferos et al.

NANO LETTERS (2009)

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Article Immunology

Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A

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Article Virology

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

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JOURNAL OF VIROLOGY (2007)

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Article Immunology

Signaling through CD70 regulates B cell activation and IgG production

R Arens et al.

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Spherical nucleic acids as an infectious disease vaccine platform

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