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Letter
Multidisciplinary Sciences
In computational models, action potential propagation in ultrathin axons is resilient despite considerable intracellular Na+ accumulation
Oron Kotler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
Article
Multidisciplinary Sciences
Interactions among diameter, myelination, and the Na/K pump affect axonal resilience to high-frequency spiking
Yunliang Zang et al.
Summary: This study investigates the impact of axonal diameter, myelination, and Na/K pump density on high-frequency spiking, revealing that larger diameter axons and myelinated axons exhibit greater resilience to high-frequency spikes. Slowing the activation of K* current can increase the Na* influx rate. The findings suggest that different strategies may be needed to improve the reliability of axonal propagation in neurons with varying channel gating kinetic parameters.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
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