期刊
POULTRY SCIENCE
卷 101, 期 3, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.psj.2021.101641
关键词
immunopotentiators; antioxidant activity; apoptosis; immune-related gene expression; Shaoxing ducklings
资金
- Key R&D Program of Zhejiang Province [2018C04014]
- China Agriculture Research System of MOF and MARA [CARS-426, CARS-42-39]
- Zhejiang Major Scientific and Technological Project of Agricultural (Livestock's) Breeding [2016C02054-12]
This study investigated the effects of chlorogenic acid, beta-D-Glucan, astragalus flavone, CpG-DNA, and chicken IgG as immunopotentiators on the antioxidant capacity, apoptosis, and immune response in Shaoxing ducklings. The results showed that these immunopotentiators improved the innate immune response in the ducklings and induced the expression of specific genes.
The abuse of antibiotics for agricultural purposes has been under scrutiny. Therefore, there is an urgent need to find antibiotic substitutes in animal production. The effects of chlorogenic acid, beta-D-Glucan, astragalus flavone, CpG-DNA, and chicken IgG on spleen antioxidant capacity, apoptosis, and the immune response in Shaoxing ducklings were investigated in this study. The ducklings treated with beta-D-Glucan, astragalus flavone, CpG-DNA, and chicken IgG showed significant reduction in catalase and superoxide dismutase activities. The five immunopotentiators facilitated caspase 3 expression and reduced Bcl2 expression in the spleen. Compared to the control group, the protein level of COX2 was significantly upregulated in the chlorogenic acid, CpG-DNA, and chicken IgG groups. The protein level of iNOS expression was significantly improved in all immunopotentiator groups, except for the astragalus flavone group. The five immunopotentiators induced IL-1 beta, IFN-alpha, IFN-beta, TNF-alpha, RIG-I, TLR3, and TLR7 gene expression. In summary, chlorogenic acid, beta-D-Glucan, astragalus flavone, CpG-DNA, and chicken IgG, as immunopotentiators, improved the innate immune response in the ducklings, which not only provides a new avenue for the development of efficient approaches to prevent pathogen infections, but also offers an alternative to antibiotics in animal production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据