4.7 Article

Thermo-responsive hydrogels from hyaluronic acid functionalized with poly(2-alkyl-2-oxazoline) copolymers with tuneable transition temperature

期刊

POLYMER
卷 244, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2022.124643

关键词

Hyaluronic acid; Thermo-responsive hydrogel; Poly(oxazoline); Grafting to

资金

  1. Normandy region
  2. European Union (European Regional Development Fund)

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HA-based thermo-responsive hydrogels were obtained through functionalization with PiPrOx-co-PnBuOx copolymers. The hydrogel transition temperature can be controlled by varying the monomeric composition.
Hyaluronic acid (HA) based thermo-responsive physical hydrogels were obtained through a one-pot functionalization of HA of different molar masses (from 38 to 990 kg mol(-1)) with thermo-responsive poly(2-isopropyl-2-oxazoline)-co-poly(2-n-butyl-2-oxazoline) (PiPrOx-co-PnBuOx) copolymers. The cloud point (T-cp) of PiPrOx-co-PnBuOxs varied according to their monomeric composition. The functionalized HA's thermo-responsiveness was characterised through rheology and UV-vis spectrophotometry. The hydrogel transition temperature could notably be modified in a controlled way by varying the comonomers ratio in the graft, with the crossing temperature of storage modulus G' and loss modulus G '' being found to rise by about 1 degrees C when increasing the iPrOx unit content within the PiPrOx-co-PnBuOx grafted copolymer by 1% for a series of modified 990 kg mol(-1) HA. The thermal transition of the material from room temperature to 37 degrees C was found out to be almost instantaneous, which is interesting for applications in injectable systems.

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