期刊
PHYTOMEDICINE
卷 100, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2022.154048
关键词
Rheumatoid arthritis; Hypoxic microenvironment; Lactate metabolism; Synovial fibroblasts; Natural compounds
资金
- Science and Technology Innovation Megaproject and Innovative Leading Talent Program of Hunan Science &Technology Department [2020SK1020, XKJ [2021]43-2021RC4035]
- Hunan Furong Distinguished Scholar Program [XJT[2020]58]
- Hunan Provincial 121 Training Project for Innovative Talents [XRSH [2019]192]
- Chinese Academy of Engineering Academician Liang Liu's Workstation of Hunan University of Chinese Medicine (HNUCM) [XKXH[2020]34]
- National First-class Disciple Construction Project of Chinese Medicine of HNUCM [XXKZ[2018]3]
Lactate metabolism plays a crucial role in the pathogenesis of rheumatoid arthritis (RA) and natural compounds show promise in treating RA by regulating lactate metabolism imbalance. Research has found that many natural compounds have the potential to treat RA by limiting lactate production, transport, and conversion.
Background: Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease characterized by persistent inflammation and hyperplasia of the synovial membrane, the degradation of cartilage, and the erosion of bones in diarthrodial joints. The inflamed joints of patients with RA have been recognized to be a site of hypoxic microenvironment which results in an imbalance of lactate metabolism and the accumulation of lactate. Lactate is no longer considered solely a metabolic waste product of glycolysis, but also a combustion aid in the progression of RA from the early stages of inflammation to the late stages of bone destruction.Purpose: To review the pathogenic mechanisms of lactate metabolism in RA and investigate the potential of natural compounds for treating RA linked to the regulation of imbalance in lactate metabolism. Methods: Research advances in our understanding of lactate metabolism in the pathogenesis of RA and novel pharmacological approaches of natural compounds by targeting lactate metabolic signaling were comprehen-sively reviewed and deeply discussed.Results: Lactate produced by RA synovial fibroblasts (RASFs) acts on targeted cells such as T cells, macrophages, dendritic cells and osteoclasts, and affects their differentiation, activation and function to accelerate the development of RA. Many natural compounds show therapeutic potential for RA by regulating glycolytic rate-limiting enzymes to limit lactate production, and affecting monocarboxylate transporter and acetyl-CoA carboxylase to inhibit lactate transport and conversion.Conclusion: Regulation of imbalance in lactate metabolism offers novel therapeutic approaches for RA, and natural compounds capable of targeting lactate metabolic signaling constitute potential candidates for devel-opment of drugs RA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据