Isoprenylated chromones from the stems of Harrisonia perforata

Three new isoprenylated chromones, named harriforatins A-C (1-3), along with 13 known compounds (4-16) were isolated from the stems of Harrisonia perforata. Their planar structures were elucidated by spectroscopic measurements. The experimental and calculated ECD curves were used to determine their absolute configurations. Most isolated compounds were evaluated for inflammation inhibition against lipopolysaccharide (LPS)induced nitric oxide (NO) production in RAW264.7 macrophages. Only compounds 5 and 6 showed inhibitory effects on NO production, with IC50 values of 42.8 and 47.0 mu M, respectively, that were stronger than that of the positive control, indomethacin (IC50 = 68.6 mu M).

Automated summary

In this study, three new isoprenylated chromones were isolated from the stems of Harrisonia perforata, and two of them showed anti-inflammatory effects.