期刊
PHYTOCHEMISTRY
卷 197, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113107
关键词
Peganum harmala L.; Zygophyllaceae; The aerial part; Alkaloids; Anti-tumor
资金
- National Natural Science Foundation of China [81773604]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX09735005]
The study isolated over 20 alkaloids from Peganum harmala L., with 3-(4-hydroxyphenyl)quinoline showing potent antiproliferative activity against HepG-2 cell lines.
Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC50 value of 3.05 mu M. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC50 values of 16.45 mu M and 17.27 mu M, respectively.
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