4.6 Review

PHYSIOLOGICAL ROLES OF HYDROGEN SULFIDE IN MAMMALIAN CELLS, TISSUES, AND ORGANS

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Protective effect of hydrogen sulfide is mediated by negative regulation of epigenetic histone acetylation in Parkinson's disease

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Summary: Derangements in monoaminergic transmission and disturbed signaling in the hypothalamic-pituitary-adrenal axis are major characteristics of Parkinson's disease (PD). Hydrogen sulfide (H2S) has been reported to have potential therapeutic effects on PD due to its regulatory role in neuronal signals. This study aimed to evaluate the hypothesis that H2S exerts protective action via inhibition of epigenetic histone acetylation.

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Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation

George J. Dugbartey et al.

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Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans

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The CBS-H2S axis promotes liver metastasis of colon cancer by upregulating VEGF through AP-1 activation

Shihao Guo et al.

Summary: Knockdown of CBS inhibits metastasis and invasion of colon cancer cells, as well as angiogenesis in vitro and in vivo. There is a positive correlation between CBS and VEGF expression in colon cancer tissues, indicating a positive feedback loop between the CBS-H2S axis and VEGF. Targeting this pathway could effectively intervene in liver metastasis of colon cancer.

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Hydrogen sulfide attenuates hyperhomocysteinemia-induced blood-brain barrier permeability by inhibiting MMP-9

Mohit Kumar et al.

Summary: The present study demonstrates that sodium hydrogen sulfide (NaHS) supplementation can ameliorate BBB dysfunction and brain edema induced by hyperhomocysteinemia (HHcy), possibly through inhibiting the expression and activity of MMP-9.

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Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

Andre G. Buret et al.

Summary: This article reviews the interaction between hydrogen sulfide (H2S), gut microbiota, and health, highlighting the toxic or therapeutic effects of H2S depending on its concentration and source. Low levels of H2S directly stabilize mucus layers, prevent microbiota biofilm fragmentation, and help resolve inflammation and tissue injury. Additionally, dietary H2S may also modulate the abundance and function of microbiota.

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Hydrogen Sulfide Subchronic Treatment Improves Hypertension Induced by Traumatic Brain Injury in Rats through Vasopressor Sympathetic Outflow Inhibition

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Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome

Theodora Panagaki et al.

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A ROS-responsive, self-immolative and self-reporting hydrogen sulfide donor with multiple biological activities for the treatment of myocardial infarction

Mengyun Yao et al.

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H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine

Maria Petrosino et al.

Summary: In this study, the binding and inhibitory mechanism of the CBS inhibitor AOAA were characterized. It was found that AOAA can be replaced by serine, which allows for the continuation of the catalytic cycle. Serine rescued the activity and function of AOAA-inhibited CBS. The results demonstrate the complexity of using AOAA as a CBS inhibitor and highlight the need for a potent, selective, and specific pharmacological CBS inhibitor.

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MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Antonia Katsouda et al.

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Emerging roles of cystathionine β-synthase in various forms of cancer

Kelly Ascencao et al.

Summary: The expression of the reverse transsulfuration enzyme cystathionine-beta-synthase (CBS) varies in different types of cancer, and is associated with survival rates. CBS and its product hydrogen sulfide (H2S) play various roles in tumor growth, cell protection, and angiogenesis in high-CBS expressing tumor cells. This article reviews the potential of CBS silencing and pharmacological CBS inhibition as potential cancer therapies, and discusses the identification of biomarkers for future targeted treatments.

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Estradiol-17β inhibits homocysteine mediated damage by promoting H2S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells

Dandan Zhang et al.

Summary: The study demonstrates that estrogen can play a protective role in patients with hyperhomocysteinemia and hypertension, which is associated with Hcy metabolism and endogenous hydrogen sulfide production. Estrogen reverses the expression of enzymes responsible for H2S production in endothelial cells treated with Hcy, indicating its potential therapeutic effects.

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Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Heng Zhang et al.

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CRY1-CBS binding regulates circadian clock function and metabolism

Sibel Cal-Kayitmazbatir et al.

Summary: The study reveals a functional interaction between cystathionine beta-synthase (CBS) and the core circadian protein cryptochrome 1 (CRY1), impacting circadian rhythms and metabolic health. CRY1 modulates CBS activity, influencing both circadian physiology and metabolic pathways. The CBS-CRY1 binding serves as a post-translational switch to regulate cellular circadian physiology and metabolic control.

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Hydrogen Sulfide Alleviates Liver Injury Through the S-Sulfhydrated-Kelch-Like ECH-Associated Protein 1/Nuclear Erythroid 2-Related Factor 2/Low-Density Lipoprotein Receptor-Related Protein 1 Pathway

Shuang Zhao et al.

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Hydrogen sulfide and vascular regulation - An update

Boyang Lv et al.

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Article Multidisciplinary Sciences

Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

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Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Hai-Jian Sun et al.

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The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

Joao Laranjinha et al.

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Permanent cystathionine-?-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity

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Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization

Katalin Eva Sikura et al.

Summary: The study demonstrates that hydrogen sulfide can regulate aortic valve calcification by inhibiting inflammation and mineralization, potentially through the association between NF-B and Runx2.

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Targeting hydrogen sulphide signaling in breast cancer

Rana Ahmed Youness et al.

Summary: Hydrogen sulphide (H2S) plays a significant role in the pathogenesis of breast cancer, and targeting H2S can mitigate the disease. Knockdown of H2S-synthesizing enzymes in specific types of breast cancer cells resulted in reduced malignancy and increased susceptibility to cytotoxic activity of immune cells. Computational analysis revealed H2S signaling pathways in different breast cancer cell lines and identified a potential upstream regulator that could synergistically abrogate cancer cell malignancy.

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Interaction among estrogen, IGF-1 and H2S on smooth muscle cell proliferation

Tian Shuang et al.

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Relaxant effect of diallyl sulfide on nonpregnant rat uterus: Involvement of voltage-dependent calcium channels

Oguzhan E. Efe et al.

Summary: Diallyl sulfide has a relaxing effect on contracted rat uterine strips and inhibits spontaneous activity, potentially by reducing calcium influx into uterine smooth muscle cells.

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Metabolomic-proteomic combination analysis reveals the targets and molecular pathways associated with hydrogen sulfide alleviating NAFLD

Zhangnan Liu et al.

Summary: This study demonstrated that H2S can alleviate NAFLD by reducing liver weight, body weight, and lipid accumulation, and improving liver pathology and serum biochemical parameters. Metabolomics and proteomics analysis revealed potential molecular targets and mechanisms of H2S in mitigating NAFLD.

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Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium

Damian D. Guerra et al.

Summary: Sulfur amino acid metabolism plays a role in reproductive physiology, with estrogen influencing gene expression and redox balance by regulating transsulfuration enzymes. In the mouse myometrium, E(2) reciprocally regulates CBS and CSE expression during different phases of the estrous cycle. E(2) specifically affects transsulfuration enzyme expression in uterine smooth muscle, suggesting a potential role in regulating uterine redox homeostasis.

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Understanding hydrogen sulfide signaling in neonatal airway disease

Marta Schiliro et al.

Summary: H2S has anti-inflammatory, antioxidant, and antiapoptotic properties at physiological concentrations; both endogenous and exogenous H2S have protective effects on the respiratory system; H2S shows potential as a novel candidate for protecting lung function following preterm birth.

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Something smells bad to plant pathogens: Production of hydrogen sulfide in plants and its role in plant defence responses

Daniel Vojtovic et al.

Summary: Studies have revealed the importance of DES in modulating H2S production, particularly in response to biotic and abiotic stress stimuli. Mutants of the model plant Arabidopsis thaliana have uncovered the molecular mechanisms of H2S as a signaling and defense molecule in plant-pathogen interactions. H2S signaling pathways, including S-persulfidation of protein cysteines, play a crucial role in activating downstream components of the H2S signaling pathway.

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Engineering macromolecular nanocarriers for local delivery of gaseous signaling molecules

Jinming Hu et al.

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Simulated sleep apnea alters hydrogen sulfide regulation of blood flow and pressure

Adelaeda Barrera et al.

Summary: In sleep apnea, airway obstruction can lead to intermittent hypoxia, which may impact hydrogen sulfide generation and regulation of blood pressure and vascular resistance. Experimental findings suggest that IH exposure could decrease CSE expression in larger resistance arteries.

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Preservation of pancreas in the University of Wisconsin solution supplemented with AP39 reduces reactive oxygen species production and improves islet graft function

Kai Nishime et al.

Summary: Hydrogen sulfide can protect organ grafts against ischemia-reperfusion injury, leading to improved success rates of islet transplantation. Preservation of pancreas in UW solution supplemented with AP39 can protect pancreatic islets against IRI and enhance islet transplantation outcomes.

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Mitochondrion-targeting near-infrared fluorescent probe for detecting intracellular nanomolar level hydrogen sulfide with high recognition rate

Kaiquan Zhang et al.

Summary: In this study, a new fluorescent probe QcyCHO was developed for rapid and accurate detection of physiological levels of H2S, with the ability to target and measure H2S levels in cells. The probe showed high recognition specificity and potential for shedding light on the biology of H2S and therapeutic development in H2S-associated diseases.

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Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy

Iram Khan Iqbal et al.

Summary: This study demonstrates that hydrogen sulfide sulfhydrates GAPDH, leading to its redistribution into the nucleus and subsequently activating SIRT1 and autophagy. This pathway plays a crucial role in restricting the growth of intracellular Mycobacterium tuberculosis through autophagy-mediated trafficking.

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Exogenous hydrogen sulfide inhibits neutrophils extracellular traps formation via the HMGB1/TLR4/p-38 MAPK/ROS axis in hyperhomocysteinemia rats

Xueying Zhao et al.

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Comparative transcriptome analysis uncovers roles of hydrogen sulfide for alleviating cadmium toxicity in Tetrahymena thermophila

Hongrui Lv et al.

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Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function

Sofia-Iris Bibli et al.

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Hydrogen sulfide induces Ca2+ release from the endoplasmic reticulum and suppresses ATP-induced Ca2+ signaling in rat spinal cord astrocytes

Takeshi Nii et al.

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Joanna L. Kelley et al.

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The mitochondria-targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model

Bridget C. Fox et al.

Summary: The study demonstrates that selective targeting of mitochondria with H2S could represent a novel drug discovery approach to delay, prevent and possibly reverse mitochondrial decline in PMD and related disorders. It provides evidence that using AP39 could restore mitochondrial function in certain PMD models where mitochondrial dysfunction is the cause of the disease pathology.

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Xuejun Jiang et al.

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Hydrogen sulfide: A versatile gaseous molecule in plants

Yamshi Arif et al.

Summary: Hydrogen sulfide is a gasotransmitter and signaling molecule in plants, playing crucial roles in various physiological processes such as metabolism and antioxidant mechanisms, interaction with plant hormones, participation in signal transduction of other molecules, and protection of proteins against oxidative damage.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Daniel Giovinazzo et al.

Summary: Alzheimer's disease is characterized by memory, executive, and motor function deterioration, with neuropathological hallmarks including neurofibrillary tangles, paired helical filaments, and amyloid plaques. Dysregulation of signaling by hydrogen sulfide has been shown during aging and may play a role in preventing hyperphosphorylation of Tau in Alzheimer's disease. Furthermore, administering the H2S donor sodium GYY4137 to mouse models of Alzheimer's disease has been shown to ameliorate motor and cognitive deficits associated with the disease.

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H2S AS A THERAPEUTIC ADJUVANT AGAINST COVID-19: WHY AND HOW?

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Review Biochemistry & Molecular Biology

Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Ayush Kumar et al.

Summary: Inflammation is a natural response to tissue injury, and uncontrolled inflammatory response can lead to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. Endogenous hydrogen sulfide, substance P, and cell adhesion molecules play important roles in the inflammatory process of acute pancreatitis.

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Decreased bioavailability of hydrogen sulfide links vascular endothelium and atrial remodeling in atrial fibrillation

Megan Watts et al.

Summary: Oxidative stress is a driving factor in the pathogenesis of atrial fibrillation (AF), with hydrogen sulfide (H2S) playing an important role in regulating electrical remodeling and susceptibility to AF. Patients with AF had significantly lower plasma sulfide levels, and those with persistent AF had even lower levels compared to paroxysmal AF patients. Additionally, CSE knockout mice showed decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type mice.

REDOX BIOLOGY (2021)

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Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul et al.

Summary: Hydrogen sulfide (H2S) was once thought to be only toxic, but is now known to also act as an endogenous signaling molecule. The effects of H2S on cellular physiology are dose-dependent, with lower concentrations being beneficial and higher concentrations being cytotoxic. In particular, H2S has contrasting effects on mitochondrial function, inhibiting the electron transport chain at higher concentrations and stimulating bioenergetics at lower concentrations.

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Hydrogen sulfide and DNA repair

Rodney Shackelford et al.

Summary: Recent evidence has shown that H2S plays a crucial role in the DNA damage response (DDR) and maintenance of genomic stability, affecting cell cycle checkpoints, DNA synthesis, and expression of various proteins. Both H2S donors and synthesis inhibitors can modulate cellular processes related to DDR, suggesting implications for cancer chemotherapy and metabolic pathways involving H2S.

REDOX BIOLOGY (2021)

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Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Csaba Szabo

Summary: H2S, previously known as a toxic gas and environmental hazard, has been found to play multiple biological regulatory roles in mammalian cells as an endogenously produced gaseous transmitter. Its effects in mitochondria serve as an electron transport stimulator in physiological concentrations, particularly significant in cancer cells where it helps maintain mitochondrial organization and DNA repair.
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Senescence and Apoptosis: Architects of Mammalian Development

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Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Elizabeth Disbrow et al.

Summary: Hydrogen sulfide (H2S) plays an important role in cerebrovascular disease and cognitive dysfunction. Studies have found elevated levels of H2S in ADRD, which are correlated with microvascular disease indices.

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Activation of Endogenous H2S Biosynthesis or Supplementation with Exogenous H2S Enhances Adipose Tissue Adipogenesis and Preserves Adipocyte Physiology in Humans

Ferran Comas et al.

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The multifaceted roles of sulfane sulfur species in cancer-associated processes

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Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy

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Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation

Yuehong Wang et al.

Summary: The study highlights the important role of hydrogen sulfide in regulating ferroptosis and lipid peroxidation in mouse myoblasts and skeletal muscles. The downregulation of CSE/H2S signaling contributes to mitochondrial damage, abnormal lipid metabolism, membrane lipid peroxidation, and ferroptotic cell death, making CSE/H2S system a potential target for preventing ferroptosis in skeletal muscle.

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Autophagy Plays a Protective Role in Sodium Hydrosulfide-Induced Acute Lung Injury by Attenuating Oxidative Stress and Inflammation in Rats

Shuai Zhang et al.

Summary: Sodium hydrosulfide (NaHS) can induce acute lung injury (ALI) in rats, with mechanisms involving autophagy, oxidative stress, and inflammatory response. NaHS increases pulmonary levels of H2S and oxidative stress-related indicators, while inhibition of autophagy exacerbates lung injury.

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Article Ophthalmology

Hydrogen sulfide is synthesized endogenously in both retinal artery and retina mostly via CSE

Selcuk Takir et al.

Summary: The study investigated the concentration levels and distribution profiles of H2S synthesizing enzymes in the bovine retina and retinal artery. CBS and CSE were found to have higher concentrations in the retinal artery compared to the retina, with 3-MST at the lowest level. The distribution of these enzymes also varied, with CBS found in endothelial and smooth muscle layers, while CSE was mainly present in the endothelial layer of the retinal artery.

EXPERIMENTAL EYE RESEARCH (2021)

Article Medicine, Research & Experimental

Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress

Jianjun Wu et al.

Summary: The study demonstrates that hydrogen sulfide (H2S) suppresses oxidative stress, ER stress, and apoptosis in chondrocytes induced by tert-butyl hydroperoxide (TBHP) by modulating the GRP78/mTOR signaling pathway. Exogenous H2S can inhibit the damage to chondrocytes caused by TBHP-induced oxidative stress.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Review Biochemistry & Molecular Biology

The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases

Yi-Zhen Wang et al.

Summary: H2S, once considered toxic, is now recognized for its protective effects in cardiovascular activities. It plays a crucial role in cardiovascular homeostasis, with studies showing its downregulation in cardiovascular diseases. Preclinical studies have demonstrated its ability to prevent CVDs and improve heart function post heart failure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Hydrogen sulphide reduces hyperhomocysteinaemia-induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis

Shan Jiang et al.

Summary: This study demonstrates that hydrogen sulfide (H2S) can enhance the activity of protein disulphide isomerase (PDI) through sulfhydration, reducing endothelial endoplasmic reticulum stress induced by hyperhomocysteinaemia (HHcy) and attenuating the development of atherosclerosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Pharmacology & Pharmacy

H2S donor molecules against cold ischemia-reperfusion injury in preclinical models of solid organ transplantation

George J. Dugbartey et al.

Summary: Cold ischemia-reperfusion injury is a major challenge in solid organ transplantation, and the use of hydrogen sulfide donor molecules has been shown to significantly mitigate this issue and improve transplant outcomes.

PHARMACOLOGICAL RESEARCH (2021)

Article Cell Biology

Meta-analysis of gene expression patterns in Down syndrome highlights significant alterations in mitochondrial and bioenergetic pathways

Laszlo Pecze et al.

Summary: Individuals with Down syndrome have a significant upregulation of genes located on chromosome 21 compared to control subjects, while genes on other chromosomes also show significant alterations. Upregulated genes encode important components of bioenergetic pathways, while genes involved in oxidative phosphorylation are mostly downregulated, potentially leading to metabolic disturbances in DS cells.

MITOCHONDRION (2021)

Article Multidisciplinary Sciences

Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation

Katalin Erdelyi et al.

Summary: Basal like breast cancer (BLBC) is an aggressive subtype of breast tumors with high Cys demand and reprogrammed Cys metabolism. CBS overexpression promotes tumor progression in BLBC, while CBS silencing makes BLBC cells more vulnerable to oxidative stress and CySSCy deprivation, leading to ferroptosis. This study suggests that persulfide-producing pathways are potential therapeutic targets for BLBC.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemistry & Molecular Biology

SIRT1 Mediates H2S-Ameliorated Diabetes-Associated Cognitive Dysfunction in Rats: Possible Involvement of Inhibiting Hippocampal Endoplasmic Reticulum Stress and Synaptic Dysfunction

Juan He et al.

Summary: The study demonstrated that hydrogen sulfide protects cognitive function in STZ-induced diabetic rats by increasing the expression of SIRT1 protein, inhibiting hippocampal ER stress and synaptic dysfunction, thereby improving cognitive deficits.

NEUROCHEMICAL RESEARCH (2021)

Article Neurosciences

Hydrogen sulfide induces Ca2+ release from intracellular Ca2+ stores and stimulates lactate production in spinal cord astrocytes

Takeshi Nii et al.

Summary: H2S inhibits mitochondrial ETC in spinal cord astrocytes, leading to Ca2+ release and increased lactate production. H2S may promote lactate supply to neurons by activating the Ca2+-sensitive NADH shuttle.

NEUROSCIENCE RESEARCH (2021)

Article Biochemistry & Molecular Biology

The H2S-generating enzyme 3-mercaptopyruvate sulfurtransferase regulates pulmonary vascular smooth muscle cell migration and proliferation but does not impact normal or aberrant lung development

Ettore Lignelli et al.

Summary: Nitric oxide, carbon monoxide, and hydrogen sulfide gasotransmitters are playing important roles in newborn physiology, diseases, and therapies. Recent studies have highlighted the potential of hydrogen sulfide in animal models of bronchopulmonary dysplasia, where exogenous hydrogen sulfide was found to mitigate the impact of oxygen toxicity on lung development. Additionally, research has shown that hydrogen sulfide is directly generated by three enzymes, with potential therapeutic implications for lung development and pulmonary vascular physiology.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2021)

Article Cell Biology

Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes

Gang Wang et al.

Summary: The study demonstrates the involvement of H2S in regulating erythrocyte functions and enhancing oxygen-carrying capacity by decreasing 2,3-BPG production. H2S promotes Hb release from the membrane to the cytosol, enhancing BPGM anchoring, and regulates erythrocyte oxygen affinity.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

Hydrogen Sulfide Restored the Diurnal Variation in Cardiac Function of Aging Mice

Huaxing Zhang et al.

Summary: The disrupted diurnal variation in cardiac function in aging mice was associated with increased oxidative stress and decreased H2S levels. H2S could restore the diurnal variation in cardiac function of aging mice by reducing oxidative stress.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Pharmacology & Pharmacy

Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells

Kelly Ascencao et al.

Summary: Hydrogen sulfide (H2S) is an important endogenous gaseous transmitter mediator that regulates cellular functions. In cancer cells, overproduction of H2S has been linked to processes such as metabolism stimulation and cell proliferation. By inhibiting H2S biosynthesis in colon cancer cells, a shift towards MET was induced, potentially contributing to anti-cancer effects.

PHARMACOLOGICAL RESEARCH (2021)

Article Plant Sciences

Regulation of growth in peach roots by exogenous hydrogen sulfide based on RNA-Seq

Xuelian Wu et al.

Summary: Exogenous application of H2S increased endogenous auxin concentration by 44.50% and regulated root growth in peach seedlings by affecting the expression of 26 auxin-related genes. Additionally, overexpression of the LATERAL ORGAN BOUNDARIES DOMAIN 16 (PpLBD16) gene significantly increased the number of lateral roots in peach.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2021)

Article Multidisciplinary Sciences

Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model

Rebecca A. Ellwood et al.

Summary: Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by muscle degeneration and weakness. Recent studies have shown that hydrogen sulfide (H2S) supplementation may improve muscle function and metabolism, suggesting a potential therapeutic approach for DMD. Deficits in H2S may contribute to DMD pathology, and delivery of H2S compounds could be a promising treatment strategy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril

Benjamin J. Maldonato et al.

Summary: This study confirmed that METTL7B is the active protein responsible for human alkyl thiol methyltransferase (TMT) activity, demonstrating its ability to methylate small molecule alkyl thiols.

SCIENTIFIC REPORTS (2021)

Review Medicine, General & Internal

The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

Mikkel Parsberg Werge et al.

Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally, possibly related to obesity and metabolic syndrome. The transsulfuration pathway (TSP) plays a vital role in maintaining sulfur balance and optimal cellular function. While a causative link between TSP and NAFLD has not been established, dysfunctions in TSP and related pathways have been reported in NAFLD and liver cirrhosis, suggesting a need for further investigation.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Geriatrics & Gerontology

Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner

Yoko O. Henderson et al.

Summary: The study investigated the effects of intermittent fasting on aging-related frailty and found that it can reduce frailty in male mice but has limited effects in females.

GEROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Selenium-Binding Protein 1 (SELENBP1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis

Elisa B. Randi et al.

Summary: The study found that SELENBP1 plays a crucial role in adipocyte differentiation in vitro. Silencing SELENBP1 led to decreased H2S levels, suppressed expression of the three classical H2S-producing enzymes, and significantly inhibited adipocyte differentiation.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

Angela Corvino et al.

Summary: Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has emerged as an important regulatory mediator in numerous human cell functions. It plays a significant role in various physio-pathological processes and the protective effects of H2S donors have been extensively studied in different disease models. The growing interest in H2S-releasing compounds highlights their potential as promising drugs for the treatment of cardiovascular diseases.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Kevin M. Casin et al.

Summary: Cardiovascular disease is the leading cause of death in the U.S. Research has shown the beneficial impact of endogenous hydrogen sulfide production on heart health; modulating H2S enzyme sources is a promising research area.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage

Britta Trautwein et al.

Summary: Genetic deletion of MST leads to reduced expression of cardiac CSE and OTR, affecting mitochondrial function, while hemorrhagic shock causes a decrease in CSE and OTR, indicating potential directions for developing cardioprotective therapies.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems

Joshua J. Scammahorn et al.

Summary: Hydrogen sulfide (H2S) serves as a crucial gaseous signaling molecule in physiological and pathophysiological processes, maintaining redox balance and promoting antioxidant mechanisms. Depletion of H2S is implicated in various diseases, leading to research interest in therapeutic interventions.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Investigating Different Forms of Hydrogen Sulfide in Cerebrospinal Fluid of Various Neurological Disorders

Viviana Greco et al.

Summary: This study investigates the levels of H2S in cerebrospinal fluid and its potential correlations with neuroinflammatory and neurodegenerative mechanisms. A validated analytical method was used to measure H2S forms, showing sensitivity, reproducibility, and robustness. The study also explores the low molecular weight proteome associated with sulphydration through proteomics analysis, paving the way for potential therapeutic applications of H2S.

METABOLITES (2021)

Article Cell Biology

The hepatic compensatory response to elevated systemic sulfide promotes diabetes

Roderick N. Carter et al.

Summary: Impaired hepatic glucose and lipid metabolism are characteristics of type 2 diabetes. Increased sulfide production or sulfide donor compounds may beneficially regulate hepatic metabolism. Lack of the liver-enriched mitochondrial SOP enzyme thiosulfate sulfurtransferase (TST) leads to normal hepatic sulfide levels but reduced protein persulfidation, affecting gluconeogenesis and lipid metabolism, particularly medium-chain fatty acid oxidation in Tst(-/-) mice.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging

Dario Pacitti et al.

Summary: Hydrogen sulfide plays important roles in lung diseases, exerting anti-inflammatory and antiviral effects, improving cell metabolism, and protecting against oxidative stress. However, dysregulation of endogenous H2S synthesis may contribute to the development of respiratory diseases, and persulfidation of H2S is reduced with aging.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Biochemistry & Molecular Biology

An evolutionary perspective on the interplays between hydrogen sulfide and oxygen in cellular functions

Jiechun Zhu et al.

Summary: This review summarized the role of hydrogen sulfide (H2S) in the origin of life and its metabolism in organisms, examined the relationship between H2S and oxygen, emphasizing the oxygen-dependent manner of H2S signaling in physiological and pathological processes.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Article Microbiology

The Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome

Domenick J. Braccia et al.

Summary: This study highlights the role of hydrogen sulfide in maintaining physiological balance and the potential mechanisms of H2S production by gut microbiota. The analysis of metagenomic data from healthy subjects and metatranscriptomic data from individuals with different conditions reveals the abundance of putative cysteine-degrading bacteria and their possible implications in human health.

FRONTIERS IN MICROBIOLOGY (2021)

Article Pharmacology & Pharmacy

Involvement of 3′,5′-cyclic inosine monophosphate in cystathionine γ-Iyase-dependent regulation of the vascular tone

Emma Mitidieri et al.

Summary: The study found that H2S-induced contraction requires an intact eNOS/NO/sGC pathway and involves cIMP as a second messenger. The contraction effect involves a transient increase of cGMP and CAMP metabolism caused by PDE5 and PDE4A, unmasking cIMP contraction. This research provides important insights into vascular regulatory mechanisms.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress

Heng-Jing Hu et al.

Summary: This study found that AF patients had decreased H2S levels, increased Warburg effect and ERS, promoting atrial fibrosis and leading to left atrial dysfunction. Sodium hydrosulfide can reverse the progression of atrial fibrosis to AF induced by AngII, manifested as reduced Warburg effect and ERS levels.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Effects of gut microbiota on atherosclerosis through hydrogen sulfide

Dan-Dan Gui et al.

Summary: Cardiovascular diseases, particularly atherosclerotic cardiovascular disease (ASCVD), are heavily influenced by environmental and genetic factors. Disruption of the human gut flora microenvironment is associated with various health problems, while hydrogen sulfide (H2S) plays crucial regulatory roles in the cardiovascular system, offering potential therapeutic direction for atherosclerosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Novel Hydrogen Sulfide (H2S)-Releasing BW-HS-101 and Its Non-H2S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier

Dominik Bakalarz et al.

Summary: The study showed that BW-HS-101 can prevent drug-induced gastric mucosal damage, reduce DNA oxidation, decrease systemic and gastric mucosal inflammation, and increase the expression of SOCS3, EGF, and HMOX-1. The gastroprotective effects of this H2S prodrug may depend on endogenous NO rather than CO activity and may be mediated by cytoprotective and anti-inflammatory pathways involving SOCS3 and EGF.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

Wanru Zhang et al.

Summary: This article summarizes the intimate relationship between detrimental gut microbiota-derived metabolites and CRC, updates the current knowledge about detrimental metabolites in CRC pathogenesis, and critically reviews multiple interventions targeting these metabolites for CRC management.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Kenneth R. Olson

Summary: This article discusses the mechanism of oxygen sensing, proposing the metabolism of hydrogen sulfide and polysulfides as a view on oxygen dependence, and compares it with the reactive oxygen species-mediated oxygen sensing mechanism.

ANTIOXIDANTS (2021)

Article Chemistry, Medicinal

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

Marina Bantzi et al.

Summary: A study identified a novel 3-MST inhibitor HMPSNE with micromolar potency, along with derivatives, showing inhibitory effects on colon cancer cell proliferation.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Medicine, Research & Experimental

GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway

Jianhua Li et al.

Summary: The study demonstrates that GYY4137 inhibits the activation of the NLRP3 inflammasome by blocking the PDGFR beta/Akt/NF-kappa B pathway, which contributes to the treatment of CLP-induced ALI in mice.

LIFE SCIENCES (2021)

Review Oncology

Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer

Ming Li et al.

Summary: Hydrogen sulfide plays a crucial role in regulating various physiological and pathological processes, including its involvement in promoting oncogenesis in breast cancer. Inhibiting H2S-producing enzymes could be a potential therapeutic strategy for controlling the growth and metastasis of breast cancer.

ONCOLOGY REPORTS (2021)

Article Pharmacology & Pharmacy

Sulfide affects the mitochondrial respiration, the Ca2+-activated F1FO-ATPase activity and the permeability transition pore but does not change the Mg2+-activated F1FO-ATPase activity in swine heart mitochondria

Salvatore Nesci et al.

Summary: The study reveals that H2S affects the activity of specific enzymes in mitochondria, leading to respiratory chain inhibition and reduced membrane potential, thereby impacting oxidative phosphorylation process.

PHARMACOLOGICAL RESEARCH (2021)

Article Plant Sciences

Hydrogen sulfide: An emerging signaling molecule regulating drought stress response in plants

Meenakshi Thakur et al.

Summary: Hydrogen sulfide (H2S) is a significant signaling molecule with potential agricultural benefits and stress response capabilities, aiding plants in adapting to environmental pressures such as drought and salinity.

PHYSIOLOGIA PLANTARUM (2021)

Article Multidisciplinary Sciences

Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics

Elisa B. Randi et al.

Summary: In mammalian cells, cyanide exhibits a biphasic effect on mitochondrial Complex IV activity, stimulating it at low concentrations and inhibiting it at higher concentrations. Low levels of cyanide lead to increased cell proliferation and ATP production, while higher levels result in inhibition of cellular bioenergetics. The presence of cyanide-producing enzymes in mammalian cells suggests a regulatory role for endogenous cyanide.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner

Nazmin Bithi et al.

Summary: The study investigates the impact of dietary restriction (DR) on protein persulfidation, finding enrichment of persulfidation in liver, kidney, muscle, and brain, but decreased levels in the heart. Mice lacking cystathionine gamma-lyase (CGL) show an overall decrease in tissue protein persulfidation numbers under DR.

NATURE COMMUNICATIONS (2021)

Article Microbiology

Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis

Georgios Renieris et al.

Summary: This study investigates the protective role of host-derived hydrogen sulfide (H2S) in combating Pseudomonas aeruginosa infection by enhancing neutrophil function and inhibiting bacterial communication, leading to higher survival rates. Experimental results show a positive correlation between H2S levels and survival, providing a new approach for treating infections by MDR bacterial pathogens.

PLOS PATHOGENS (2021)

Review Allergy

Hydrogen sulfide as a novel biomarker of asthma and chronic obstructive pulmonary disease

Yasuhito Suzuki et al.

Summary: Hydrogen sulfide (H2S) is recognized as the third important gas-signaling molecule, with dual effects of anti-inflammatory and antioxidant properties, but potentially pro-inflammatory under certain conditions. In respiratory disorders, H2S has shown promise as a novel biomarker for predicting asthma risks and identifying inflammatory phenotypes for personalized treatment.

ALLERGOLOGY INTERNATIONAL (2021)

Review Pharmacology & Pharmacy

Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology

Aleksandra Danielak et al.

Summary: The novel NSAIDs synthesized with the ability to release gas mediators NO, H2S and CO show promising effects in terms of anti-inflammatory potency and GI safety, providing a potential solution to the adverse effects associated with traditional NSAIDs on the gastrointestinal tract.

FRONTIERS IN PHARMACOLOGY (2021)

Article Oncology

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Shanwen Chen et al.

Summary: The study identified a reciprocal regulation between xCT and the transsulfuration pathway, which presents a targetable metabolic vulnerability. CTH derived H2S increased the stability of xCT through persulfidation of OTU domain-containing ubiquitin aldehyde-binding protein 1 at cysteine 91. Treatment with AOAA and Erastin resulted in synthetic lethality both in vitro and in vivo, primarily through increased ferroptosis and apoptosis.

NEOPLASIA (2021)

Article Biochemistry & Molecular Biology

Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

Rachael Bok et al.

Summary: The study revealed that cystathionine gamma-lyase (CSE) plays a crucial role in maintaining the glutathione (GSH)/glutathione disulfide (GSSG) balance in uterine arteries for nitric oxide signaling, which is necessary for normal estrogen (E-2) stimulation. These findings have implications for pregnancy pathophysiology and the selective hormone responses of specific vascular beds.

REDOX BIOLOGY (2021)

Article Cell Biology

Hypertension and Aging Affect Liver Sulfur Metabolism in Rats

Dominika Szlezak et al.

Summary: Hypertension and age were found to affect hepatic sulfur metabolism and the production of H2S in rats, with SHRs showing higher capacity for H2S generation. Differences in gene expression and enzyme activity related to sulfur metabolism were observed between WKY and SHR, as well as between different age groups of rats.
Article Biochemistry & Molecular Biology

Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion

Smriti Juriasingani et al.

Summary: Cold preservation is the standard care for renal grafts, but research on alternatives like perfusion at higher temperatures and supplementing preservation solutions with hydrogen sulfide (H2S) has shown promising results. This study found that subnormothermic perfusion at 21 degrees C with H2S-supplemented blood improved renal graft outcomes, as indicated by increased urine output, reduced apoptotic injury, and changes in pro-survival gene expression patterns. Further research is needed for the clinical translation of this approach.

BIOMOLECULES (2021)

Review Biochemistry & Molecular Biology

The Impact of H2S on Obesity-Associated Metabolic Disturbances

Ferran Comas et al.

Summary: Hydrogen sulfide (H2S) has emerged as a new signaling molecule, playing extensive physiological and pathophysiological roles in human disorders by targeting proteins, enzymes, and transcription factors through post-translational modification known as persulfidation. This review article critically examines the current literature on the role of H2S in obesity-related metabolic disturbances, particularly its mechanisms of action.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide as a Potential Therapy for Heart Failure-Past, Present, and Future

Kyle B. LaPenna et al.

Summary: Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Characterization of Endogenous and Extruded H2S and Small Oxoacids of Sulfur (SOS) in Cell Cultures

Ottis Scrivner et al.

Summary: This study characterized and quantified endogenous hydrogen sulfide and small oxoacids of sulfur in a range of cell lines, showing varying concentrations in different cell types and continuous efflux into surrounding media, implying a role in cell signaling and vascular physiology.

ACS CHEMICAL BIOLOGY (2021)

Article Chemistry, Analytical

Accurate Fluorescence Diagnosis of Cancer Based on Sequential Detection of Hydrogen Sulfide and pH

Zun-Pan She et al.

Summary: Cancer is a leading cause of death worldwide, but early detection can prevent or cure many cancers. Novel near-infrared fluorescent probe (CyO-DNP) for sequential detection of H2S and H+ has been synthesized. This probe shows potential for monitoring endogenous H2S and H+ in cancer cells and imaging exogenous and endogenous H2S and H+ in mice, with the ability to accurately discriminate between normal and tumor mice.

ANALYTICAL CHEMISTRY (2021)

Article Oncology

Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors

Ekin Ozluk et al.

Summary: In this study, it was found that cystathionine gamma-lyase (CSE) expression is increased in several common testicular germ-cell tumor types, with the highest expression seen in embryonal carcinomas which tend to have a relatively aggressive clinical course. This suggests a potential role for hydrogen sulfide in testicular cancer progression.

ANTICANCER RESEARCH (2021)

Review Biochemistry & Molecular Biology

The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review

Fatemeh Yarmohammadi et al.

Summary: Cardiac diseases are on the rise due to lifestyle changes, urbanization, and aging, with oxidative stress playing a key role in cardiac injury progression. Hydrogen sulfide (H2S) has shown potential in improving various cardiac conditions through antioxidant and anti-ER stress-related activities, by regulating Nrf2 expression and its signaling pathway in myocytes.

BIOFACTORS (2021)

Article Geriatrics & Gerontology

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex

Jing-Ying Lin et al.

Summary: Ageing is a complex biological process that affects cognitive function and energy metabolism. Exercise training can reduce apoptosis and oxidative stress, decreasing the likelihood of brain damage.

BIOGERONTOLOGY (2021)

Article Biochemistry & Molecular Biology

Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels

Birgitte S. Jensen et al.

Summary: Hydrogen sulfide (H2S) plays a key role in regulating basal metabolic rate and mitochondrial respiration in hibernating mammals. During torpor, H2S accumulates in the liver and inhibits mitochondrial respiration, while during arousal and summer, this effect is reversed.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Biochemistry & Molecular Biology

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Rong-Hsuan Wang et al.

Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Max Y. Zhang et al.

Summary: This review discusses the generation of STS from H2S, its clinical applications, potential therapeutic benefits as well as the molecular mechanisms underlying these clinical applications and future perspectives in kidney transplantation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Donor Heart Preservation with Hydrogen Sulfide: A Systematic Review and Meta-Analysis

Imran A. Ertugrul et al.

Summary: Studies have shown that postconditioning with hydrogen sulfide (H2S) has significant robust effects in limiting infarct size, decreasing release of cardiac injury markers, lowering levels of oxidative stress, and improving cardiac function. Postconditioning with slow-releasing H2S donors offers a valuable opportunity for novel therapies in cardiac preservation for transplantation. Further research evaluating the long-term effects of H2S treatment and its effects in large animal studies before clinical implementation is recommended.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Gut microbiota-derived metabolites in CRC progression and causation

Nishu Dalal et al.

Summary: Recent research suggests that dysbiosis and improper concentrations of microbial metabolites in the gut may lead to the carcinogenesis of colorectal cancer. Specific bacteria, such as Fusobacterium nucleaturm, Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis and Clostridium septicum, have been implicated in CRC development by producing metabolites that promote inflammation and cancer progression. Metabolites derived from gut microbiota are now considered as potential factors in CRC diagnosis, prognosis, and therapy based on recent studies.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

Article Medicine, Research & Experimental

Hydrogen sulfide inhibits calcium and phosphorus loss after fracture by negatively regulating glucocorticoid/glucocorticoid receptor α

Feng Liao et al.

Summary: The study found that H2S can inhibit calcium and phosphorus loss after fracture through various mechanisms, including reducing glucocorticoid secretion and inhibiting glucocorticoid receptor alpha activity.

LIFE SCIENCES (2021)

Article Cell Biology

Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner

Takeo Uba et al.

Summary: Polysulfides play a crucial role in modulating intracellular oxygen homeostasis, regulating HIF activation, and influencing hypoxia-induced gene expression in a VHL- and mitochondria-dependent manner.

MITOCHONDRION (2021)

Review Oncology

Protective effect of hydrogen sulfide on the kidney

Hu Zhang et al.

Summary: This review article summarizes the important role of hydrogen sulfide (H2S) in production, metabolism, and physiological functions in the body, as well as recent research progress regarding its role in renal injury and fibrosis.

MOLECULAR MEDICINE REPORTS (2021)

Article Neurosciences

Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide

Kohei Koike et al.

Summary: The study identifies an ultrasensitive olfactory sensor in mice for detecting hydrogen sulfide, which activates a specific type of sensory neurons and triggers defensive responses. This activation mechanism includes elevation of stress hormone levels, stress-related grooming behavior, and conditional avoidance of dangerous environments.

NEURON (2021)

Review Cell Biology

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors

Jing Dai et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 poses a threat to global economy and public health, with various receptors identified as potential mediators of virus infection. Higher H2S levels have been associated with better survival rates in COVID-19 patients, suggesting a potential role for H2S in modulating virus receptors and patient outcomes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Multidisciplinary Sciences

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance

Konstantin Shatalin et al.

Summary: The emergence of resistance to clinical antibiotics has prompted the development of a new antimicrobial strategy targeting the bacterial hydrogen sulfide (H2S) defense system. Inhibitors of the bacterial cystathionine g-lyase (CSE) have been found to enhance the effectiveness of bactericidal antibiotics against major human pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. These inhibitors also disrupt bacterial tolerance, reduce biofilm formation, and decrease the number of persister bacteria surviving antibiotic treatment.

SCIENCE (2021)

Article Multidisciplinary Sciences

Sulfide catabolism ameliorates hypoxic brain injury

Eizo Marutani et al.

Summary: The sensitivity of the brain to hypoxia is inversely related to the levels of sulfide:quinone oxidoreductase (SQOR) and its capacity to catabolize sulfide in mice, rats, and naturally hypoxia-tolerant ground squirrels. Silencing SQOR increased brain sensitivity to hypoxia, while neuron-specific SQOR expression prevented hypoxia-induced sulfide accumulation and ischemic brain injury. Pharmacological scavenging of sulfide maintained mitochondrial respiration in hypoxic neurons and made mice resistant to hypoxia, indicating a potential therapeutic target for ischemic brain injury.

NATURE COMMUNICATIONS (2021)

Article Pharmacology & Pharmacy

Endogenous Hydrogen Sulfide Is an Important Factor in Maintaining Arterial Oxygen Saturation

Yan Huang et al.

Summary: The gasotransmitter H2S plays a crucial role in maintaining normal oxygen saturation in the lungs and preventing lung injury, inflammation, and oxidative stress. GYY4137 treatment was effective in ameliorating these conditions in both genetic deficiency and hypoxia-induced mouse models.

FRONTIERS IN PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

H2S Donor and Bone Metabolism

Yanming Hao et al.

Summary: Hydrogen sulfide (H2S) plays a significant role in bone metabolism, particularly in diseases like osteoporosis and osteoarthritis. H2S releasing agents have shown promising effects in treating metabolic bone diseases and are being explored as potential therapeutic agents in the future.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity

E. Panza et al.

Summary: The study reveals a defective TSP pathway activity in DMD and demonstrates that H2S donors can effectively recover impaired locomotor activity and reduce inflammation in skeletal muscle tissues of both DMD patients and mdx mice.

REDOX BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

Paari Dominic et al.

Summary: The study observed significantly reduced levels of NO and H2S in COVID-19 patients, with higher levels in deceased patients. Free sulfide levels were found to be highly predictive of COVID-19 infection.

REDOX BIOLOGY (2021)

Article Cell Biology

Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

Sofia C. Nunes et al.

Summary: Ovarian cancer is one of the deadliest gynecologic malignancies, with resistance to therapy being a major challenge. Research suggests that cysteine plays a key role in adapting to hypoxic microenvironments by reprogramming cellular metabolism and energy production mechanisms.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Mark R. Hellmich et al.

Summary: The upregulation of CBS in cancer cells has been identified as a tumor-promoting factor, leading to the synthesis of a novel CBS-targeting prodrug YD0251 with higher efficacy in inhibiting tumor growth compared to the prototypical CBS inhibitor AOAA. The prodrug was successful in suppressing tumor growth in vivo with low toxicity, and a potential plasma marker for CBS-expressing tumors was identified for potential future theranostic applications to match CBS inhibitor therapy with high-CBS expressors.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Qiaojing Yan et al.

Summary: Tan IIA may work through the induction of endogenous H2S via the ER and cAMP signaling pathway. It can attenuate oxidative stress and promote cell survival.

ANTIOXIDANTS (2021)

Article Immunology

Hydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway

Zixi Chen et al.

Summary: The NLRP3 inflammasome plays a crucial role in inflammatory responses, and hydrogen sulfide contributes to uterine quiescence by inhibiting the TLR4/NF-kappa B signaling pathway and downstream NLRP3 inflammasome activation.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Review Biochemistry & Molecular Biology

H2S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?

Francesca Gorini et al.

Summary: The delicate balance between vasodilators and vasoconstrictors controlled by endothelial cells is crucial for vascular homeostasis. Therapeutic approaches targeting inflammation-related vascular injury may help treat cardiovascular diseases and conditions related to endothelium dysfunction, including COVID-19. Hydrogen sulfide's anti-inflammatory activity and other biological functions at the endothelial level make it a promising option for treating diseases involving vascular pathobiology such as SARS-CoV-2 infection.

BIOMEDICINES (2021)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Inhibits TMPRSS2 in Human Airway Epithelial Cells: Implications for SARS-CoV-2 Infection

Giulia Pozzi et al.

Summary: The COVID-19 pandemic has affected nearly 190 million people worldwide with over 4 million confirmed deaths. Finding protective and therapeutic strategies is urgent, and H2S may help reduce the potential for SARS-CoV-2 to enter respiratory epithelial cells.

BIOMEDICINES (2021)

Article Medicine, Research & Experimental

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

Daniel J. Silver et al.

Summary: Research shows that consuming a high-fat diet may worsen glioblastoma (GBM), mainly by inhibiting the production of hydrogen sulfide (H2S) and increasing the enrichment of cancer stem cells (CSC). Increasing the bioavailability of H2S may help suppress the development of GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Cell Biology

Hydrogen Sulfide Upregulates Acid-sensing Ion Channels via the MAPK-Erk1/2 Signaling Pathway

Zhong Peng et al.

Summary: The study demonstrates that H2S can regulate both the expression and function of ASICs, potentially through the MAPK signaling pathway. This regulation may involve roles in learning and memory, protection during seizure activity, and modulation of nociception.

FUNCTION (2021)

Article Biochemistry & Molecular Biology

Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage

Xiaofeng Jiang et al.

Summary: The study revealed that DNA damage can elevate intracellular H2S levels by upregulating autophagy and H2S-generating enzyme CGL. Furthermore, exogenous H2S intervention can partially alleviate genotoxic stress in autophagy-deficient cells.

CELL CHEMICAL BIOLOGY (2021)

Article Medicine, General & Internal

Protective and therapeutic effect of hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with cyclophosphamide

Fikriye Yasemin Ozatik et al.

Summary: Hydrogen sulfide has a protective and therapeutic effect on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction, indicating its potential in facilitating cancer treatment.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine γ-lyase (CSE) represses trophoblast syncytialization

Juan Liu et al.

Summary: This study identified a variety of dynamically O-GlcNAcylated proteins in human placental trophoblasts, with a focus on the role of CSE O-GlcNAcylation in trophoblast differentiation. Enhanced CSE O-GlcNAcylation and H2S production in preeclamptic placentas were found to be associated with restricted trophoblast differentiation.

CELL CHEMICAL BIOLOGY (2021)

Article Medicine, Research & Experimental

Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study

Yan-Ming Hao et al.

Summary: This study found that serum H2S levels were increased in patients with osteopenia and osteoporosis, and negatively correlated with femoral BMD. The downregulation of CBS and CSE expression in femur tissues of osteoporosis patients suggests their involvement in the pathogenesis of osteoporosis. Serum phosphorus levels, alkaline phosphatase, hemoglobin, and triglycerides were closely associated with CBS and CSE scores in femur tissues.

MEDICAL SCIENCE MONITOR (2021)

Article Biochemistry & Molecular Biology

Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats

Amira Moustafa

Summary: Gasotransmitters are gaseous molecules synthesized within the body that play roles in various physiological and pathological processes at the cellular level. Long-term exposure to restraint stress has been shown to negatively impact male reproductive functions in rats, with changes in hormone levels and alterations in the expression of gasotransmitter producing enzymes in the hypothalamus and testes.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

Dan Wang et al.

Summary: Increased levels of CBS and H2S have been found in pediatric CML patients and cells, inhibition of CBS can reduce cell proliferation, induce apoptosis, and inhibit cell migration.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

Role of hydrogen sulfide donors in cancer development and progression

Ebenezeri Erasto Ngowi et al.

Summary: There are numerous potential cancer therapeutic targets emerging recently, with hydrogen sulfide playing a role in regulating cellular activities. However, the outcome of treating cancer cells with H2S donors depends on multiple factors. Various signaling pathways have been reported to be altered following treatments with H2S donors, suggesting their potential in cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Cell Biology

CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation

Shuang Cai et al.

Summary: The research indicates that methionine deficiency during early pregnancy significantly reduces the number of embryo implantation sites, CBS expression, and products of the transsulfuration pathway, which can be reversed by maternal methionine supplementation. Additionally, CBS influences signaling pathways related to cell proliferation and DNA synthesis, and there may be a correlation between CBS and MAT2A, suggesting a potential involvement of MAT2A in these processes.

CELL PROLIFERATION (2021)

Review Chemistry, Medicinal

Pharmacological modulation of the hydrogen sulfide (H2S) system by dietary H2S-donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus

Eugenia Piragine et al.

Summary: Type 2 diabetes is a common age-related metabolic disorder with increasing interest in the pharmacological modulation of endogenous H2S-system due to its role in pathogenesis and prevention of complications. H2S-releasing molecules could be a promising strategy in clinical management and prevention of macro- and micro-vascular complications associated with hyperglycemia, while naturally occurring H2S-donors from dietary organosulfur compounds have potential therapeutic benefits.

PHYTOTHERAPY RESEARCH (2021)

Review Pharmacology & Pharmacy

Hydrogen sulfide and dermatological diseases

Silvia A. Coavoy-Sanchez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase

Kaspar M. Trocha et al.

CARDIOVASCULAR RESEARCH (2020)

Review Pharmacology & Pharmacy

The role of the gasotransmitter hydrogen sulfide in pathological calcification

Mariela Castelblanco et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Activatable Small-Molecule Hydrogen Sulfide Donors

Carolyn M. Levinn et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Review Biochemistry & Molecular Biology

A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood

Birgitte Jensen et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biochemistry & Molecular Biology

Direct Proteomic Mapping of Cysteine Persulfidation

Ling Fu et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biochemistry & Molecular Biology

Hemeproteins as Targets for Sulfide Species

Fernando Martin Boubeta et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Pharmacology & Pharmacy

Modulation of the functions of myeloid-derived suppressor cells: A new strategy of hydrogen sulfide anti-cancer effects

Paola De Cicco et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Persulphide-responsive transcriptional regulation and metabolism in bacteria

Takayuki Shimizu et al.

JOURNAL OF BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Sulfhydration of perilipin 1 is involved in the inhibitory effects of cystathionine gamma lyase/hydrogen sulfide on adipocyte lipolysis

Yajun Ding et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular Inflammation in HepG2 Cells

Ya-Di Wang et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2020)

Review Pharmacology & Pharmacy

Hydrogen sulfide and hepatic lipid metabolism - a critical pairing for liver health

Julie J. Loiselle et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Pharmacology & Pharmacy

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Armita Abdollahi Govar et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Engineering, Biomedical

A hydrogen sulfide-releasing alginate dressing for effective wound healing

Xia Zhao et al.

ACTA BIOMATERIALIA (2020)

Article Biochemistry & Molecular Biology

Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis

Yanjie Zhang et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biochemistry & Molecular Biology

Altered dynamics in the circadian oscillation of clock genes in serum-shocked NIH-3T3 cells by the treatment of GYY4137 or AOAA

Maria Romerowicz-Misielak et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Article Pharmacology & Pharmacy

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase

Maria Peleli et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Hydrogen Sulfide Switch Phenomenon Regulating Autophagy in Cardiovascular Diseases

Wen Luo et al.

CARDIOVASCULAR DRUGS AND THERAPY (2020)

Editorial Material Cell Biology

A Central Role for the Gasotransmitter H2S in Aging

Rafael de Cabo et al.

CELL METABOLISM (2020)

Review Biochemistry & Molecular Biology

Role of Hydrogen Sulfide in Chronic Diseases

Na Yang et al.

DNA AND CELL BIOLOGY (2020)

Article Environmental Sciences

Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Nastaran Azarbarz et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Flavia Sunzini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Agriculture, Multidisciplinary

Transcriptome analysis reveals delaying of the ripening and cell-wall degradation of kiwifruit by hydrogen sulfide

Xiaocui Lin et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

Article Multidisciplinary Sciences

Caveolae in CNS arterioles mediate neurovascular coupling

Brian W. Chow et al.

NATURE (2020)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Maternal disease and gasotransmitters

Aishwarya Rengarajan et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide

Basak Donertas Ayaz et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Multidisciplinary Sciences

Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer's disease

Tanusree Sen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

Md. Aejazur Rahman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

Vikram Saini et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

Ewelina Zaorska et al.

BIOMOLECULES (2020)

Article Cell Biology

Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p

Wen-long Xue et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Physiology

H2S-stimulated bioenergetics in chicken erythrocytes and the underlying mechanism

Zhuping Jin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Gabriel Gojon et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Medicine, Research & Experimental

Contribution of Hydrogen Sulfide to Dilation of Rat Cerebral Arteries after Ischemia/Reperfusion Injury

G. I. Lobov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Review Cell Biology

A Metabolic Roadmap for Somatic Stem Cell Fate

C. Hai Ly et al.

CELL METABOLISM (2020)

Article Anatomy & Morphology

Clinical Significance of CBS and CCL21 in Gallbladder Adenocarcinomas and Squamous Cell/Adenosquamous Carcinomas

Daiqiang Li et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2020)

Review Biochemistry & Molecular Biology

Nitric Oxide and Hydrogen Sulfide: A Nice Pair in the Respiratory System

Salvatore Fuschillo et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Review Materials Science, Biomaterials

The Emerging Roles of the Gaseous Signaling Molecules NO, H2S, and CO in the Regulation of Stem Cells

Ben Wang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Review Biochemistry & Molecular Biology

The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives

Martin Kadlec et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

New Insights into Molecular Links Between Microbiota and Gastrointestinal Cancers: A Literature Review

Yash Raj Rastogi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations

Pramod Kumar Yadav et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO

Sibile Pardue et al.

REDOX BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction

Khoa Nguyen et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2020)

Review Cell Biology

The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection

Ioanna Andreadou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Dentistry, Oral Surgery & Medicine

Cystathionine gamma-lyase aggravates periodontal damage in traumatic occlusion mouse models

Liyuan Chen et al.

JOURNAL OF PERIODONTAL RESEARCH (2020)

Article Multidisciplinary Sciences

Divergent effect of fast- and slow-releasing H2S donors on boar spermatozoa under oxidative stress

Eliana Pintus et al.

SCIENTIFIC REPORTS (2020)

Review Endocrinology & Metabolism

Chromatin -remodeling links metabolic signaling to gene expression

Ashby J. Morrison

MOLECULAR METABOLISM (2020)

Article Multidisciplinary Sciences

Origin of complexity in haemoglobin evolution

Arvind S. Pillai et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

Cystathionine-beta-synthase: Molecular Regulation and Pharmacological Inhibition

Karim Zuhra et al.

BIOMOLECULES (2020)

Review Cell Biology

H2S as a potential defense against COVID-19?

Guangdong Yang

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Chemistry, Multidisciplinary

Alleviating Cellular Oxidative Stress through Treatment with Superoxide-Triggered Persulfide Prodrugs

Yin Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemistry & Molecular Biology

On H2S Prodrugs

Gabriel Gojon

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biochemistry & Molecular Biology

H2S-producing enzymes in anoxia-tolerant vertebrates: Effects of cold acclimation, anoxia exposure and reoxygenation on gene and protein expression

Arne O. Melleby et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Modulation of acid-sensing ion channels by hydrogen sulfide

Mohona Mukhopadhyay et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D. Kruithof et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Article Medicine, Research & Experimental

Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats

Rui Yang et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Biochemistry & Molecular Biology

Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells

Geeta Rao et al.

FASEB JOURNAL (2020)

Review Pharmacology & Pharmacy

Anti-inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID-19 therapy

Valentina Citi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Relaxing Effect of Hydrogen Sulfide on Isolated Bovine Mesenteric Lymph Nodes

G. Lobov

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Medicine, Research & Experimental

The Role of Hydrogen Sulfide in the Dilatation of Mesenteric Lymphatic Vessels in Bulls

G. I. Lobov

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Gastroenterology & Hepatology

Helicobacter pyloriinfection modulates endogenous hydrogen sulfide production in gastric cancer AGS cells

Yoshinari Kawahara et al.

HELICOBACTER (2020)

Article Biochemistry & Molecular Biology

Hypersensitivity of Airway Reflexes Induced by Hydrogen Sulfide: Role of TRPA1 Receptors

Chi-Li Chung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Treatment Improves Post-Infarct Remodeling and Long-Term Cardiac Function in CSE Knockout and Wild-Type Mice

Leigh J. Ellmers et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Molecular Mapping of Hydrogen Sulfide Targets in Normal Human Keratinocytes

Olivia Gross-Amat et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Effects of Hydrogen Sulfide Donor NaHS on Porcine Vascular Wall-Mesenchymal Stem Cells

Chiara Bernardini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Cystathione beta-synthase regulates HIF-1 alpha stability through persulfidation of PHD2

Anindya Dey et al.

SCIENCE ADVANCES (2020)

Review Oncology

Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival

Jacinta Serpa

FRONTIERS IN ONCOLOGY (2020)

Article Cell Biology

Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration

Fangping Lu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Endocrinology & Metabolism

Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis

Banqin Wang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Cell Biology

Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells

Yong Huang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Neurosciences

Nitric oxide is fundamental to neurovascular coupling in humans

Ryan L. Hoiland et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

Article Chemistry, Multidisciplinary

Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging

Rongchen Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Pharmacology & Pharmacy

Hydrogen sulfide signalling in the CNS - Comparison with NO

Hideo Kimura

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Effect of Hydrogen Sulfide on Deformability of Rat Erythrocytes

O. E. Fadyukova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Hematology

Hydrogen sulfide reduces the activity of human endothelial cells

Eberhard Grambow et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2020)

Review Pharmacology & Pharmacy

Hydrogen sulfide: An endogenous regulator of the immune system

Nahzli Dilek et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

The role of host defences in Covid 19 and treatments thereof

Maurizio Dattilo

MOLECULAR MEDICINE (2020)

Review Biotechnology & Applied Microbiology

Poly(ADP-ribose) polymerase inhibition: past, present and future

Nicola J. Curtin et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Pharmacology & Pharmacy

Role of hydrogen sulfide in cardiovascular ageing

Lara Testai et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Spectroscopy

A highly sensitive endoplasmic reticulum-targeting fluorescent probe for the imaging of endogenous H2S in live cells

Lei Zhou et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

Review Biochemistry & Molecular Biology

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides

Tomohiro Sawa et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Uterine Dysfunction in Diabetic Mice: The Role of Hydrogen Sulfide

Emma Mitidieri et al.

ANTIOXIDANTS (2020)

Review Biochemical Research Methods

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic

Hieronim Jakubowski

Summary: Homocystinuria due to CBS deficiency is a genetic disorder with severe physiological abnormalities affecting multiple organ systems, for which current treatments are inadequate. Recent research suggests that dysregulated proteostasis plays a key role in the pathogenesis, providing insights for potential drug development and therapeutic interventions.

EXPERT REVIEW OF PROTEOMICS (2020)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Modulates Adult and Reparative Neurogenesis in the Cerebellum of Juvenile Masu Salmon, Oncorhynchus masou

Evgeniya Pushchina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

Roles of Hydrogen Sulfide Donors in Common Kidney Diseases

Ebenezeri Erasto Ngowi et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

Eleni Dongo et al.

BIOMOLECULES (2020)

Article Genetics & Heredity

Ethylmalonic encephalopathy: Clinical course and therapy response in an uncommon mild case with a severe ETHE1 mutation

Melike Ersoy et al.

MOLECULAR GENETICS AND METABOLISM REPORTS (2020)

Article Geriatrics & Gerontology

Lifespan and healthspan benefits of exogenous H2S inC. elegansare independent from effects downstream ofeat-2mutation

Li Theng Ng et al.

NPJ AGING AND MECHANISMS OF DISEASE (2020)

Article Ophthalmology

Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy

Ghulam Mohammad et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Article Critical Care Medicine

H2S in acute lung injury: a therapeutic dead end(?)

Tamara Merz et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

Article Multidisciplinary Sciences

Hydrogen sulfide facilitates reprogramming and trans-differentiation in 3D dermal fibroblast

Elena A. Ostrakhovitch et al.

PLOS ONE (2020)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels

Yan Li et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Laszlo Pecze et al.

MOLECULAR MEDICINE (2020)

Article Nutrition & Dietetics

Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism

Viktor Kozich et al.

JOURNAL OF NUTRITION (2020)

Review Chemistry, Medicinal

Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

Honghua Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Toxicology

Involvement of claudin-5 in H2S-induced acute lung injury

Ping Geng et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases

Honggang Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Toxicology

Cystathionine β Synthase/Hydrogen Sulfide Signaling in Multiple Myeloma Regulates Cell Proliferation and Apoptosis

Minmin Zhang et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2020)

Review Cell Biology

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

Rubaiya Tabassum et al.

NEURAL REGENERATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Release of endogenous hydrogen sulfide in enteric nerve cells suppresses intestinal motility during severe acute pancreatitis

Ribin Liao et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

Article Medicine, General & Internal

Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1

Xuan Kang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Review Critical Care Medicine

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Eizo Marutani et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

Article Integrative & Complementary Medicine

Prodrugs of hydrogen sulfide and related sulfur species: recent development

Yuan Zheng-Nan et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2020)

Review Pharmacology & Pharmacy

Eicosanoids in the gastrointestinal tract

John L. Wallace

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells

Shigemoto Fujii et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Regulators of the transsulfuration pathway

Juan I. Sbodio et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Long-term exercise restores hydrogen sulfide in the kidney and contributes to exercise benefits in 5/6 nephrectomized rats

Behjat Seifi et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2019)

Article Biochemistry & Molecular Biology

Hydrogen sulfide upregulates renal AQP-2 protein expression and promotes urine concentration

Renfei Luo et al.

FASEB JOURNAL (2019)

Review Chemistry, Medicinal

Role of hydrogen sulfide in cerebrovascular alteration during aging

Juyeon Mun et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter

Jyotirmaya Behera et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Reproductive Biology

Ovine uterine artery hydrogen sulfide biosynthesis in vivo: effects of ovarian cycle and pregnancy

Thomas J. Lechuga et al.

BIOLOGY OF REPRODUCTION (2019)

Review Reproductive Biology

Gasotransmitters in pregnancy: from conception to uterine involution

Damian D. Guerra et al.

BIOLOGY OF REPRODUCTION (2019)

Article Pharmacology & Pharmacy

Treatment with hydrogen sulfide donor attenuates bone loss induced by modeled microgravity

Ming Yang et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Hydrogen sulfide, reactive sulfur species and coping with reactive oxygen species

Kenneth R. Olson

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Chemistry, Inorganic & Nuclear

Saying NO to H2S: A Story of HNO, HSNO, and SSNO-

Ivana Ivanovic-Burmazovic et al.

INORGANIC CHEMISTRY (2019)

Article Medicine, Research & Experimental

Protective effect of a hydrogen sulfide donor on balloon injury-induced restenosis via the Nrf2/HIF-1 signaling pathway

Ken Ling et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Article Gastroenterology & Hepatology

Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis

Shanwen Chen et al.

JOURNAL OF CROHNS & COLITIS (2019)

Article Pharmacology & Pharmacy

Mycobacterium tuberculosis metC (Rv3340) derived hydrogen sulphide conferring bacteria stress survival

Lambert Nzungize et al.

JOURNAL OF DRUG TARGETING (2019)

Review Plant Sciences

Nitric oxide and hydrogen sulfide in plants: which comes first?

Francisco J. Corpas et al.

JOURNAL OF EXPERIMENTAL BOTANY (2019)

Article Cell Biology

Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy

Hanan H. Ahmed et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Expression and activity of hydrogen sulfide generating enzymes in murine macrophages stimulated with lipopolysaccharide and interferon-

Patrycja Bronowicka-Adamska et al.

MOLECULAR BIOLOGY REPORTS (2019)

Article Pharmacology & Pharmacy

GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation

Lei Jiang et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

Article Endocrinology & Metabolism

Hydrogen sulfide inhibits Ca2+-induced mitochondrial permeability transition pore opening in type-1 diabetes

A. Sashi Papu John et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Review Cell Biology

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

Review Pharmacology & Pharmacy

Role of hydrogen sulfide in cognitive deficits: Evidences and mechanisms

Jin-Ting He et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Comprehensive analysis of how experimental parameters affect H2S measurements by the monobromobimane method

Tamas Ditroi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Impact of Pharmacological Inhibition of Hydrogen Sulphide Production in the SOD1G93A-ALS Mouse Model

Alida Spalloni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biology

Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles

Birgitte Jensen et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2019)

Article Gastroenterology & Hepatology

TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility

Laura Grasa et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2019)

Article Chemistry, Multidisciplinary

Data-Driven Identification of Hydrogen Sulfide Scavengers

Chun-tao Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Cell Biology

Developmental Cell Death in the Cerebral Cortex

Fong Kuan Wong et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

Article Biochemistry & Molecular Biology

S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury

Yujia Yuan et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Biochemistry & Molecular Biology

H2S attenuates endoplasmic reticulum stress in hypoxia-induced pulmonary artery hypertension

Jianjun Wu et al.

BIOSCIENCE REPORTS (2019)

Article Environmental Sciences

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both

Masahiro Akiyama et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2019)

Article Pharmacology & Pharmacy

Potassium channels contribute to the increased sensitivity of the rabbit carotid artery to hydrogen sulfide in diabetes

Jose M. Centeno et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

EPR detection of sulfanyl radical during sulfhemoglobin formation - Influence of catalase

Augustin C. Mot et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis

Ravinder R. Gaddam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine gamma-Lyase-An Animal Model of Cystathioninuria

Noriyuki Akahoshi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

Marouane Libiad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Cardiac & Cardiovascular Systems

A Novel Mechanism of Sildenafil Improving the Excessive Proliferation and H2S Production in Pulmonary Arterial Smooth Muscle Cells

Zhenya Yao et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Altered neurovascular coupling and brain arginine metabolism in endothelial nitric oxide synthase deficient mice

Ashwini Hariharan et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes

Itamar Goren et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Article Endocrinology & Metabolism

Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice

Yu Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Article Medicine, Research & Experimental

H2S-Mediated Changes in Erythrocyte Volume: Role of Gardos Channels, Na+,K+,2Cl- Cotransport and Anion Exchanger

Yu G. Birulina et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Food Science & Technology

Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction

Ferran Comas et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Materials Science, Biomaterials

Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering

Laura Gambari et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Urology & Nephrology

Mechanisms of hypoxia signalling: new implications for nephrology

Johannes Schoedel et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Biochemistry & Molecular Biology

The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium

Jia-Wen Xu et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Article Multidisciplinary Sciences

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Theodora Panagaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide regulation of renal and mesenteric blood flow

Humberto Morales-Loredo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

Masayuki Ide et al.

EMBO MOLECULAR MEDICINE (2019)

Article Pathology

The effects of intravitreal H2S application on apoptosis in the retina and cornea in experimental glaucoma model

Zuleyha Erisgin et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2019)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

Laura Gambari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

17?-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine ?-lyase

Xingyan Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

Mental retardation in Down syndrome: Two ways to treat

Pierre P. Kamoun

MEDICAL HYPOTHESES (2019)

Article Biochemistry & Molecular Biology

Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics

Turtushikh Damba et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Review Cell Biology

Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury

Qin Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Cell Biology

Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies

Masoud Akbari et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Multidisciplinary Sciences

Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys

Hanno Maassen et al.

PLOS ONE (2019)

Review Biochemistry & Molecular Biology

Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis

Vera A. Reitsema et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Biochemistry & Molecular Biology

Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria

Navid Sahebekhtiari et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Pharmacology & Pharmacy

Nitric oxide in the gastrointestinal tract: opportunities for drug development

John L. Wallace

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Sulfane sulfur - new findings on an old topic

Malgorzata Iciek et al.

ACTA BIOCHIMICA POLONICA (2019)

Article Pharmacology & Pharmacy

Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition

Avisek Majumder et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019)

Article Urology & Nephrology

Endogenous H2S production deficiencies lead to impaired renal erythropoietin production

Jennifer Leigh et al.

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL (2019)

Review Endocrinology & Metabolism

Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin

Francois Blachier et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2019)

Article Medicine, Research & Experimental

The protective effects of hydrogen sulfide on the myocardial ischemia via regulating Bmal1

Jiaqin Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Immunology

H2S, a Bacterial Defense Mechanism against the Host Immune Response

Tracy Toliver-Kinsky et al.

INFECTION AND IMMUNITY (2019)

Article Biochemistry & Molecular Biology

Hydrogen sulfide alleviates uranium-induced rat hepatocyte cytotoxicity via inhibiting Nox4/ROS/p38 MAPK pathway

Juan Yi et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

Review Biochemistry & Molecular Biology

Hydrogen sulfide signaling in mitochondria and disease

Brennah Murphy et al.

FASEB JOURNAL (2019)

Article Geriatrics & Gerontology

Marmoset as a Model to Study Kidney Changes Associated With Aging

Hak Joo Lee et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

Article Cell Biology

Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis

Chun-tao Yang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Review Biotechnology & Applied Microbiology

Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases

Antonio Cuadrado et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Cell Biology

Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease

Dong-Dong Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Biochemistry & Molecular Biology

Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model

Emanuela G. Garattini et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Article Oncology

Cystathionine gamma lyase aggravates orthodontic root resorption in mice

Caizhu Lu et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

Review Medicine, Research & Experimental

The role of hydrogen sulfide in gastric mucosal damage

Fang Shen et al.

MEDICAL GAS RESEARCH (2019)

Review Medicine, General & Internal

Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

Rubaiya Tabassum et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

Article Ophthalmology

Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis

Akash K. George et al.

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (2019)

Article Physiology

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

Saranya Rajendran et al.

COMPREHENSIVE PHYSIOLOGY (2019)

Article Biochemistry & Molecular Biology

Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

Xiaoli Ge et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

Dayana Benchoam et al.

ANTIOXIDANTS (2019)

Article Gastroenterology & Hepatology

Cystathionine beta-synthase is required for body iron homeostasis

Yu-Fu Zhou et al.

HEPATOLOGY (2018)

Article Genetics & Heredity

Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria

Tomas Majtan et al.

HUMAN MUTATION (2018)

Article Biochemistry & Molecular Biology

Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation

Mariela Castelblanco et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Chemistry, Medicinal

Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues

Yueqin Zheng et al.

MEDICINAL RESEARCH REVIEWS (2018)

Article Gastroenterology & Hepatology

Antidiarrheal effect of sodium hydrosulfide in diabetic rats: In vitro and in vivo studies

M. Saghazadeh-Dezfuli et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Article Biochemistry & Molecular Biology

Cytochrome c Reduction by H2S Potentiates Sulfide Signaling

Victor Vitvitsky et al.

ACS CHEMICAL BIOLOGY (2018)

Article Urology & Nephrology

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

Qing Kuang et al.

AMERICAN JOURNAL OF NEPHROLOGY (2018)

Article Physiology

Role of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries

Jesus Prieto-Lloret et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Chemistry, Multidisciplinary

A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential

Chadwick R. Powell et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Biochemistry & Molecular Biology

A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation?

George J. Dugbartey et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide-Releasing Therapeutics: Translation to the Clinic

John L. Wallace et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction

Jing Wang et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Biochemistry & Molecular Biology

Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity

Christopher Hine et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Hematology

Cystathionine -Lyase Modulates Flow-Dependent Vascular Remodeling

Shuai Yuan et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Cystathionine gamma lyase-H2S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading

Shenzheng Mo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Pharmacology & Pharmacy

Hydrogen sulfide as a regulatory factor in kidney health and disease

Balakuntalam S. Kasinath et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

Chadwick R. Powell et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease

Bindu D. Paul et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells

Christopher L. Bianco et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

The dichotomous role of H2S in cancer cell biology? Deja all over again

Khosrow Kashfi

BIOCHEMICAL PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

Csaba Szabo

BIOCHEMICAL PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells

Ashley A. Untereiner et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice

Guangdong Yang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)

Article Biochemistry & Molecular Biology

Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis

Fengjiao Zheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Pharmacology & Pharmacy

Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide

Ning Ma et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction

Joseph Y. Cheung et al.

CARDIOVASCULAR TOXICOLOGY (2018)

Review Cell Biology

Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia

Nanduri R. Prabhakar et al.

CELL AND TISSUE RESEARCH (2018)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Cell Biology

Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice

Xi-Ling Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Neurosciences

Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain

Mohit Kumar et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

Review Biochemistry & Molecular Biology

Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease

O. Karmin et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury

Valentina Citi et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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NaHS prejunctionally inhibits the cardioaccelerator sympathetic outflow in pithed rats

David Centurion et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Cystathionine -synthase regulates mitochondrial morphogenesis in ovarian cancer

Prabir Kumar Chakraborty et al.

FASEB JOURNAL (2018)

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Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes

Rajesh Parsanathan et al.

FREE RADICAL RESEARCH (2018)

Article Peripheral Vascular Disease

Cystathionine γ-Lyase Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure

Istvan Andras Szijarto et al.

HYPERTENSION (2018)

Article Medicine, Research & Experimental

Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway

Maojun Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide in Physiology and Pathogenesis of Bacteria and Viruses

Virender Kumar Pal et al.

IUBMB LIFE (2018)

Article Biochemistry & Molecular Biology

Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond

Weining Niu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Food Science & Technology

Volatile sulfur compounds in tropical fruits

Robert J. Cannon et al.

JOURNAL OF FOOD AND DRUG ANALYSIS (2018)

Article Biochemistry & Molecular Biology

Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions

Birgitte Jensen et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2018)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

Yuuki Shimizu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Article Chemistry, Physical

Charge Transfer and π to π* Transitions in the Visible Spectra of Sulfheme Met Isomeric Structures

Hector D. Arbelo-Lopez et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2018)

Article Biotechnology & Applied Microbiology

Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

Tomas Majtan et al.

MOLECULAR THERAPY (2018)

Article Biochemistry & Molecular Biology

Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity

Emma Mitidieri et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS/H2S pathway

Yaqi Shen et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

AMPK activation promotes gastroprotection through mutual interaction with the gaseous mediators H2S, NO, and CO

Simone de Araujo et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Review Cell Biology

Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System

Ulfuara Shefa et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells

Ricardo de Pascual et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2018)

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Reduced adipose tissue H2S in obesity

Antonia Katsouda et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Multidisciplinary Sciences

Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington's disease

Juan I. Sbodio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Geriatrics & Gerontology

Symbiotic Origin of Aging

Edward F. Greenberg et al.

REJUVENATION RESEARCH (2018)

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H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells

Caitlyn Bourque et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure

Dong-Suk Kim et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice

Sebastiaan D. Hemelrijk et al.

SCIENTIFIC REPORTS (2018)

Article Pharmacology & Pharmacy

The detection and quantification, in vivo and in real time, of hydrogen sulfide in ethanol-induced lesions in rat stomachs using an ion sensitive electrode

Josue A. Velazquez-Moyado et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2018)

Article Microbiology

Neutrophils use superoxide to control bacterial infection at a distance

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PLOS PATHOGENS (2018)

Review Neurosciences

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Ulfuara Shefa et al.

NEURAL PLASTICITY (2018)

Review Endocrinology & Metabolism

Hydrogen Sulfide in Diabetic Complications: Focus on Molecular Mechanisms

Ling-ling Qian et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2018)

Article Biochemistry & Molecular Biology

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease

Saurabh Rajpal et al.

REDOX BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase

Kenneth R. Olson et al.

REDOX BIOLOGY (2018)

Review Neurosciences

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Sandesh Panthi et al.

TRANSLATIONAL NEURODEGENERATION (2018)

Article Geriatrics & Gerontology

Hydrogen sulfide ameliorates aging-associated changes in the kidney

Hak Joo Lee et al.

GEROSCIENCE (2018)

Review Biochemistry & Molecular Biology

Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria?

Lauren K. Wareham et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Review Cardiac & Cardiovascular Systems

Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease

Zhen Li et al.

CIRCULATION RESEARCH (2018)

Review Cell Biology

The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Ya-Dan Wen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Pharmacology & Pharmacy

Reversal of Sp1 transactivation and TGFβ1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation

Melanie Racine et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases

Lei Zhang et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Oncology

Cystathione beta-Synthase Is Increased in Thyroid Malignancies

Elba A. Turbat-Herrera et al.

ANTICANCER RESEARCH (2018)

Review Biochemistry & Molecular Biology

Gas Signaling Molecules and Mitochondrial Potassium Channels

Agnieszka Walewska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide: A Therapeutic Option in Systemic Sclerosis

Amaal Eman Abdulle et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Medicine, General & Internal

The biologic effect of hydrogen sulfide and its function in various diseases

Qing Xiao et al.

MEDICINE (2018)

Article Biochemistry & Molecular Biology

H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures

Smriti Juriasingani et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Cell Biology

Hydrogen Sulfide Ameliorates Developmental Impairments of Rat Offspring with Prenatal Hyperhomocysteinemia

O. V. Yakovleva et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Clinical Neurology

Vascular Protection of Hydrogen Sulfide on Cerebral Ischemia/Reperfusion Injury in Rats

Ji-Yue Wen et al.

FRONTIERS IN NEUROLOGY (2018)

Article Clinical Neurology

Efficacy of isothiocyanate-based compounds on different forms of persistent pain

Elena Lucarini et al.

JOURNAL OF PAIN RESEARCH (2018)

Article Gastroenterology & Hepatology

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger

Xiaopeng Bai et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Pharmacology & Pharmacy

Sulfur-containing gaseous signal molecules, ion channels and cardiovascular diseases

Wen Yu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Protein S-sulfhydration by hydrogen sulfide in cardiovascular system

Guoliang Meng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Chemistry, Multidisciplinary

Chemical Biology of H2S Signaling through Persulfidation

Milos R. Filipovic et al.

CHEMICAL REVIEWS (2018)

Article Cell Biology

Cystathionine β-Synthase Is Necessary for Axis Development in Vivo

Shubhangi Prabhudesai et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance

Tiziana Corsello et al.

ANTIOXIDANTS (2018)

Review Biochemistry & Molecular Biology

H2S biosynthesis and catabolism: new insights from molecular studies

Peter Rose et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Gastroenterology & Hepatology

Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents

Larisse Tavares Lucetti et al.

DIGESTIVE DISEASES AND SCIENCES (2017)

Article Endocrinology & Metabolism

Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency

Andrew A. M. Morris et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2017)

Article Biochemical Research Methods

Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel

Angelo D'Alessandro et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Article Medicine, Research & Experimental

H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension

Shasha Feng et al.

LABORATORY INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation

Hong Zhou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Mechanisms of defense against products of cysteine catabolism in the nematode Caenorhabditis elegans

Leonid Livshits et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species

Dorottya Garai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis

Sang Jun Han et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

DNA damage related crosstalk between the nucleus and mitochondria

Mohammad Saki et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Chromatin associated mechanisms in base excision repair - nucleosome remodeling and DNA transcription, two key players

Herve Menoni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Medicine, Research & Experimental

Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy

Biao Liang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Review Biochemistry & Molecular Biology

The Role of Hemoproteins: Hemoglobin, Myoglobin and Neuroglobin in Endogenous Thiosulfate Production Processes

Anna Bilska-Wilkosz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA

Sabine Arndt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products

Victor Vitvitsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin

Markus Ruetz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Oncology

Effects of exogenous hydrogen sulfide on the proliferation and invasion of human Bladder cancer cells

Hui Liu et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2017)

Article Ophthalmology

Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo

Jenaye Robinson et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2017)

Article Biology

Mitochondria are not captive bacteria

Ajith Harish et al.

JOURNAL OF THEORETICAL BIOLOGY (2017)

Review Medicine, Research & Experimental

Anti-inflammatory effects of H2S during acute bacterial infection: a review

Francesca Benedetti et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Article Medicine, Research & Experimental

Sulfate-reducing bacteria stimulate gut immune responses and contribute to inflammation in experimental colitis

Vanessa Ribeiro Figliuolo et al.

LIFE SCIENCES (2017)

Article Biochemistry & Molecular Biology

Candidate gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation

H. Toinet Cronje et al.

MATRIX BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Transcriptome analysis of drought-responsive genes regulated by hydrogen sulfide in wheat (Triticum aestivum L.) leaves

Hua Li et al.

MOLECULAR GENETICS AND GENOMICS (2017)

Article Medicine, Research & Experimental

Hydrogen sulfide prevents homocysteine-induced endoplasmic reticulum stress in PC12 cells by upregulating SIRT-1

Chun-Yan Wang et al.

Molecular Medicine Reports (2017)

Article Oncology

Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement

Haiya Pu et al.

MOLECULAR MEDICINE REPORTS (2017)

Article Biochemistry & Molecular Biology

Hydrogen Sulphide Production in Healthy and Ulcerated Gastric Mucosa of Rats

Patrycja Bronowicka-Adamska et al.

MOLECULES (2017)

Article Biochemistry & Molecular Biology

Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer

John I. Toohey

MOLECULES (2017)

Article Cell Biology

H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing

Wei Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

Mechanism of H2S-mediated protection against oxidative stress in Escherichia coli

Alexander Mironov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Complementary roles of gasotransmitters CO and H2S in sleep apnea

Ying-Jie Peng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

A subcellular map of the human proteome

Peter J. Thul et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

A pathology atlas of the human cancer transcriptome

Mathias Uhlen et al.

SCIENCE (2017)

Article Spectroscopy

Colorimetric detection of endogenous hydrogen sulfide production in living cells utilizing silver-embedded polymer membrane

Yong Jin Ahn et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2017)

Article Endocrinology & Metabolism

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes

Tian-xiao Hu et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2017)

Article Neurosciences

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors

Aleksey V. Yakovlev et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Takaaki Akaike et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions

Simona Rapposelli et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

Nikolay Bazhanov et al.

SCIENTIFIC REPORTS (2017)

Review Microbiology

Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

Hamidreza Jamaati et al.

FRONTIERS IN MICROBIOLOGY (2017)

Article Pharmacology & Pharmacy

Electrophysiological Investigation of the Subcellular Fine Tuning of Sympathetic Neurons by Hydrogen Sulfide

Manuel Dominguez-Rodriguez et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Role of Hydrogen Sulfide in Retinal Diseases

Jiantong Du et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation

Li-Long Pan et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications

Jianming Kang et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Pharmacology & Pharmacy

Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice

Sheng Jin et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Hypoxia and hydrogen sulfide differentially affect normal and tumor-derived vascular endothelium

Serena Bianco et al.

REDOX BIOLOGY (2017)

Article Multidisciplinary Sciences

Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes

Daniel A. Gonzalez-Carter et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis

Alexander Perniss et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model

Poojya Anantharam et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Review Pharmacology & Pharmacy

Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system

Giuseppe Cirino et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Cell Biology

Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications

Csaba Szabo

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2017)

Review Pharmacology & Pharmacy

Hydrogen Sulfide and Inflammatory Joint Diseases

Elena F. Burguera et al.

CURRENT DRUG TARGETS (2017)

Article Biochemistry & Molecular Biology

Changes in hydrogen sulfide in rats with hepatic cirrhosis in different stages

Ning Zhang et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2017)

Article Biotechnology & Applied Microbiology

Epigenetics-by-Sex Interaction for Coronary Artery Disease Risk Conferred by the Cystathionine γ-Lyase Gene Promoter Methylation

Efstathia Giannakopoulou et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2017)

Article Gastroenterology & Hepatology

Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide

Ancy D. Nalli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Nikolay Bazhanov et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

Review Biochemistry & Molecular Biology

The Origin and Diversification of Mitochondria

Andrew J. Roger et al.

CURRENT BIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation

Parisa Aghagolzadeh et al.

ATHEROSCLEROSIS (2017)

Article Biochemistry & Molecular Biology

Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways

Xiao-Yi Hou et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Review Pharmacology & Pharmacy

Hydrogen sulphide as a signalling molecule regulating physiopathological processes in gastrointestinal motility

M. Jimenez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

The Role of the Hydrogen Sulfide Pathway in Male and Female Urogenital System in Health and Disease

Roberta d'Emmanuele di Villa Bianca et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Article Biochemistry & Molecular Biology

Cystathionine γ-Lyase Deficiency Exacerbates CCl4-Induced Acute Hepatitis and Fibrosis in the Mouse Liver

Lei Ci et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Article Developmental Biology

Endogenous hydrogen sulfide contributes to uterine quiescence during pregnancy

Xingji You et al.

REPRODUCTION (2017)

Article Cell Biology

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

Christopher Hine et al.

CELL METABOLISM (2017)

Article Pharmacology & Pharmacy

Exercise restores bioavailability of hydrogen sulfide and promotes autophagy influx in livers of mice fed with high-fat diet

Bing Wang et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017)

Article Physiology

Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure

Erminia Donnarumma et al.

COMPREHENSIVE PHYSIOLOGY (2017)

Article Hematology

Microvascular Endothelial Dysfunction in Obesity Is Driven by Macrophage-Dependent Hydrogen Sulfide Depletion

Joseph Candela et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Review Neurosciences

Hydrogen sulfide, endoplasmic reticulum stress and alcohol mediated neurotoxicity

Akash K. George et al.

BRAIN RESEARCH BULLETIN (2017)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism

Gregory J. Weber et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Cell Biology

Vascular biology of hydrogen sulfide

Nancy L. Kanagy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

NFAT regulation of cystathionine γ-lyase expression in endothelial cells is impaired in rats exposed to intermittent hypoxia

Laura V. Gonzalez Bosc et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

The interaction of estrogen and CSE/H2S pathway in the development of atherosclerosis

Hongzhu Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Pharmacology & Pharmacy

Involvement of endogenous central hydrogen sulfide (H2S) in hypoxia-induced hypothermia in spontaneously hypertensive rats

Joao Paulo J. Sabino et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Biological chemistry of hydrogen sulfide and persulfides

Ernesto Cuevasanta et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)

Article Endocrinology & Metabolism

Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes

Fan Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

Review Materials Science, Biomaterials

An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration

Gretchen S. Selders et al.

REGENERATIVE BIOMATERIALS (2017)

Article Biochemistry & Molecular Biology

H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation

Guihua Lu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Pharmacology & Pharmacy

Meningeal blood flow is controlled by H2S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway

Maria Dux et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

The endoplasmic reticulum: structure, function and response to cellular signaling

Dianne S. Schwarz et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Medicine, Research & Experimental

Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia

Valentina Vellecco et al.

CLINICAL SCIENCE (2016)

Article Biochemistry & Molecular Biology

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

Rajesh K. Mistry et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Endocrinology & Metabolism

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

Francesco Grassi et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

Review Biotechnology & Applied Microbiology

Gasotransmitters in cancer: from pathophysiology to experimental therapy

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2016)

Review Cell Biology

The role of hydrogen sulfide in aging and age-related pathologies

Bernard W. Perridon et al.

AGING-US (2016)

Article Cell Biology

Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway

Yu Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Bryan T. Hackfort et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels

Jay S. Naik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery

Maggie M. Kuo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Physiology

Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption

Nicole C. Krause et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Is an Antiviral and Antiinflammatory Endogenous Gasotransmitter in the Airways

Teodora Ivanciuc et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

Article Chemistry, Multidisciplinary

Hydrogen Sulfide Donors Activated by Reactive Oxygen Species

Yu Zhao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Biochemistry & Molecular Biology

Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms

Ashley A. Untereiner et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Biochemistry & Molecular Biology

SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells

Liping Xie et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Dentistry, Oral Surgery & Medicine

Endogenous hydrogen sulfide is involved in osteogenic differentiation in human periodontal ligament cells

Sheng-Dan Cen et al.

ARCHIVES OF ORAL BIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

Derek J. Hausenloy et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Article Biochemistry & Molecular Biology

DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice

Hua-Ping Du et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

The mitochondrial carnitine/acylcarnitine carrier is regulated by hydrogen sulfide via interaction with C136 and C155

Nicola Giangregorio et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

Article Pharmacology & Pharmacy

Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells

Fumiko Sekiguchi et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2016)

Article Biochemistry & Molecular Biology

Mechanisms of mitophagy: putting the powerhouse into the doghouse

Joel S. Riley et al.

BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Effects of Dietary Selenium on Inflammation and Hydrogen Sulfide in the Gastrointestinal Tract in Chickens

Cong Wu et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2016)

Article Neurosciences

Cryogenic role of central endogenous hydrogen sulfide in the rat model of endotoxic shock

Rodrigo A. R. Fernandez et al.

BRAIN RESEARCH (2016)

Article Cell Biology

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Sarah J. Mitchell et al.

CELL METABOLISM (2016)

Article Cell Biology

Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease

Yuanyuan Liu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Protective effect of allyl methyl disulfide on acetaminophen-induced hepatotoxicity in mice

Yongchun Zhang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Review Cardiac & Cardiovascular Systems

The Coronary Circulation as a Target of Cardioprotection

Gerd Heusch

CIRCULATION RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner

Yuuki Shimizu et al.

CIRCULATION-HEART FAILURE (2016)

Article Medicine, General & Internal

New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain

Poornima Venkat et al.

CROATIAN MEDICAL JOURNAL (2016)

Article Biochemistry & Molecular Biology

Cystathionine beta-synthase regulates endothelial function via protein S-sulfhydration

Sounik Saha et al.

FASEB JOURNAL (2016)

Article Biochemistry & Molecular Biology

Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: The adaptive response

Martin Beaumont et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Medicine, Research & Experimental

Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3β/β-catenin signaling pathway

Ning Ge et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Medicine, Research & Experimental

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase

Akbar Ahmad et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Review Public, Environmental & Occupational Health

Effect of environmental exposure to hydrogen sulfide on central nervous system and respiratory function: a systematic review of human studies

Eunjung Lim et al.

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2016)

Article Pharmacology & Pharmacy

Diurnal Temporal Blood H2S Variations Correlate with the Circadian Rhythm of Vascular Contraction and Blood Pressure

Mecit Orhan Uludag et al.

INTERNATIONAL JOURNAL OF PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress

Omer Kabil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine -Synthase

Sebastian Carballal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Gastroenterology & Hepatology

Effect of exogenous hydrogen sulfide on gastric acid secretion

Hongzhao Sun et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Review Clinical Neurology

Hydrogen polysulfide (H2S n ) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO)

Hideo Kimura

JOURNAL OF NEURAL TRANSMISSION (2016)

Article Chemistry, Multidisciplinary

Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols

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Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Regulation of Cystathionine γ-Lyase in Mammalian Cells by Hypoxia

Maoxian Wang et al.

BIOCHEMICAL GENETICS (2014)

Article Biochemistry & Molecular Biology

The cystathionine γ-lyase/hydrogen sulfide system maintains cellular glutathione status

Zheng-Wei Lee et al.

BIOCHEMICAL JOURNAL (2014)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression

Naoharu Takano et al.

BIOCHEMICAL JOURNAL (2014)

Review Biochemistry & Molecular Biology

Chemical aspects of hydrogen sulfide measurements in physiological samples

Peter Nagy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Pharmacology & Pharmacy

K(V)7 channels are involved in hypoxia-induced vasodilatation of porcine coronary arteries

E. R. Hedegaard et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

H2S modulates duodenal motility in male rats via activating TRPV1 and KATP channels

Wen Lu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition

Mariarosaria Bucci et al.

CARDIOVASCULAR RESEARCH (2014)

Article Cell Biology

Role of Calcium Channels in the Protective Effect of Hydrogen Sulfide in Rat Cardiomyoblasts

Daniele Avanzato et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

The possible role of hydrogen sulfide as a modulator of hemostatic parameters of plasma

Beata Olas et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2014)

Review Cardiac & Cardiovascular Systems

Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

David J. Polhemus et al.

CIRCULATION RESEARCH (2014)

Article Biochemistry & Molecular Biology

H2S exposure elicits differential expression of candidate genes in fish adapted to sulfidic and non-sulfidic environments

Michael Tobler et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2014)

Article Urology & Nephrology

Hydrogen sulfide treatment improves long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury

Ian Lobb et al.

CUAJ-Canadian Urological Association Journal (2014)

Article Biochemistry & Molecular Biology

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

Sathnur Pushpakumar et al.

CURRENT MEDICINAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

Zaid Altaany et al.

CURRENT MEDICINAL CHEMISTRY (2014)

Review Microbiology

Bacterial gasotransmitters: an innate defense against antibiotics

Lyly Luhachack et al.

CURRENT OPINION IN MICROBIOLOGY (2014)

Article Pharmacology & Pharmacy

Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ Stress

Hagir B. Suliman et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Fisheries

The immunomodulation of inducible hydrogen sulfide in Pacific oyster Crassostrea gigas

Zhibin Sun et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2014)

Article Environmental Sciences

α-ENaC, therapeutic target of dexamethasone on hydrogen sulfide induced acute pulmonary edema

Lei Jiang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2014)

Article Chemistry, Inorganic & Nuclear

Kinetics and Mechanism of the Reaction of Hydrogen Sulfide with Diaquacobinamide in Aqueous Solution

Denis S. Salnikov et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2014)

Article Pharmacology & Pharmacy

Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: Role of BKCa

Jiehong Huang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Role of hydrogen sulfide in the formalin-induced orofacial pain in rats

Alberto F. Donatti et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

Review Urology & Nephrology

A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease

Giorgio Gandaglia et al.

EUROPEAN UROLOGY (2014)

Article Integrative & Complementary Medicine

Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats

Jian-qing Lin et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels

Jacobo Elies et al.

FASEB JOURNAL (2014)

Article Biochemistry & Molecular Biology

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation

Inge G. Revsbech et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Gastroenterology & Hepatology

Carbon Monoxide, Hydrogen Sulfide, and Nitric Oxide as Signaling Molecules in the Gastrointestinal Tract

Gianrico Farrugia et al.

GASTROENTEROLOGY (2014)

Article Dentistry, Oral Surgery & Medicine

Hydrogen sulphide increases hepatic differentiation of human tooth pulp stem cells compared with human bone marrow stem cells

M. Okada et al.

INTERNATIONAL ENDODONTIC JOURNAL (2014)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Represses Androgen Receptor Transactivation by Targeting at the Second Zinc Finger Module

Kexin Zhao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Characterization and Interaction Studies of Two Isoforms of the Dual Localized 3-Mercaptopyruvate Sulfurtransferase TUM1 from Humans

Benjamin Fraesdorf et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Inter-domain Communication of Human Cystathionine β-Synthase STRUCTURAL BASIS OF S-ADENOSYL-L-METHIONINE ACTIVATION

Thomas J. McCorvie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Alleviates Diabetic Nephropathy in a Streptozotocin-induced Diabetic Rat Model

Xiang Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Cardiac & Cardiovascular Systems

Inhibitory Effect of Hydrogen Sulfide on Platelet Aggregation and the Underlying Mechanisms

Lingling Zhong et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2014)

Article Endocrinology & Metabolism

Role of microRNA29b in blood-brain barrier dysfunction during hyperhomocysteinemia: an epigenetic mechanism

Anuradha Kalani et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Review Clinical Neurology

Therapeutic benefits of H2S in Alzheimer's disease

Hai-Jun Wei et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2014)

Article Immunology

H2S Increases Survival during Sepsis: Protective Effect of CHOP Inhibition

Marcella Ferlito et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

Yali Wang et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Neurosciences

Hydrogen Sulfide Treatment Induces Angiogenesis After Cerebral Ischemia

Hyunduk Jang et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2014)

Article Chemistry, Multidisciplinary

Why Can Hydrogen Sulfide Permeate Cell Membranes?

Saleh Riahi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Medicine, Research & Experimental

Subsets of regulatory T cells and their roles in allergy

Huiyun Zhang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Article Medicine, Research & Experimental

Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-kB inhibition

Francesca Benedetti et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Article Urology & Nephrology

Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy

Kai Song et al.

KIDNEY INTERNATIONAL (2014)

Article Oncology

Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

Naoharu Takano et al.

MOLECULAR CANCER RESEARCH (2014)

Article Biochemistry & Molecular Biology

Cytokine-Induced GAPDH Sulfhydration Affects PSD95 Degradation and Memory

Sajad Mir et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

Involvement of CSE/H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes

Zhe Pan et al.

LIPIDS IN HEALTH AND DISEASE (2014)

Article Biotechnology & Applied Microbiology

Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the proliferation of hepatoma cells

Yan Pan et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2014)

Article Multidisciplinary Sciences

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

Bindu D. Paul et al.

NATURE (2014)

Review Gastroenterology & Hepatology

Bile acid receptors as targets for drug development

Frank G. Schaap et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Hydrogen sulfide improves spatial memory impairment and decreases a production of Aβ in APP/PS1 transgenic mice

Xuan-li He et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

Article Neurosciences

Hippocampal cystathionine beta synthase in young and aged mice

J. J. Bruintjes et al.

NEUROSCIENCE LETTERS (2014)

Article Urology & Nephrology

Exogenous hydrogen sulfide prevents kidney damage following unilateral ureteral obstruction

Dapeng Jiang et al.

NEUROUROLOGY AND URODYNAMICS (2014)

Review Biochemistry & Molecular Biology

Controversies and conundrums in hydrogen sulfide biology

Kenneth R. Olson et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Oxidation of hydrogen sulfide by human liver mitochondria

Nada Helmy et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Hydrogen sulfide and nitric oxide interactions in inflammation

Maria Letizia Lo Faro et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Working with H2S: Facts and apparent artifacts

Rudolf Wedmann et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Sulfide-inhibition of mitochondrial respiration at very low oxygen concentrations

J. Matallo et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Hydrogen sulfide and the liver

Sarathi Mani et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage

Pauline M. Snijder et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Review Plant Sciences

Hydrogen sulfide and cell signaling: Team player or referee?

J. T. Hancock et al.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2014)

Article Multidisciplinary Sciences

Genetic Targets of Hydrogen Sulfide in Ventilator-Induced Lung Injury - A Microarray Study

Sashko Spassov et al.

PLOS ONE (2014)

Article Pharmacology & Pharmacy

Comparison of the effects of methanethiol and sodium sulphide on uterine contractile activity

Ana Mijuskovic et al.

PHARMACOLOGICAL REPORTS (2014)

Article Pharmacology & Pharmacy

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism

Laura Gambari et al.

PHARMACOLOGICAL RESEARCH (2014)

Review Biology

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity

Olivia A. Shipton et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Article Multidisciplinary Sciences

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Tomoaki Ida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

June Ereno-Orbea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema

Ying-Jie Peng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

Adrienne L. King et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Physiology

Oxygen-related chemoreceptor drive to breathe during H2S infusion

Philippe Haouzi et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2014)

Article Ophthalmology

ELEVATED HYDROGEN SULFIDE LEVELS IN VITREOUS BODY AND PLASMA IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY

Ruijin Ran et al.

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES (2014)

Article Respiratory System

Sputum-to-serum hydrogen sulfide ratio in COPD

Junpei Saito et al.

THORAX (2014)

Article Multidisciplinary Sciences

Parallel evolution of cox genes in H2S-tolerant fish as key adaptation to a toxic environment

Markus Pfenninger et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos

Nannan Ning et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway

Mirjam Eberhardt et al.

NATURE COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

Antisecretory Effect of Hydrogen Sulfide on Gastric Acid Secretion and the Involvement of Nitric Oxide

Seyyed Ali Mard et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Pharmacology & Pharmacy

Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation

Vincenzo Brancaleone et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Review Physiology

Modulation of hydrogen sulfide by vascular hypoxia

Jessica M. Osmond et al.

HYPOXIA (2014)

Article Biochemistry & Molecular Biology

Correlation of Serum Homocysteine Levels with the Severity of Coronary Artery Disease

Vijetha Shenoy et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Persulfide Reactivity in the Detection of Protein S-Sulfhydration

Jia Pan et al.

ACS CHEMICAL BIOLOGY (2013)

Article Cell Biology

Transport of H2S and HS- across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl-/HS- exchange

Michael L. Jennings

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Article Endocrinology & Metabolism

Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9

Sourav Kundu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Article Gastroenterology & Hepatology

Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments

Melissa V. Chan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

Hydrogen sulfide modulates sinusoidal constriction and contributes to hepatic micorcirculatory dysfunction during endotoxemia

Eric J. Norris et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse

Abel D. Ang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca2+-activated K+ channels and smooth muscle Ca2+ sparks

Olan Jackson-Weaver et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Article Physiology

H2S concentrations in the arterial blood during H2S administration in relation to its toxicity and effects on breathing

Candice M. Klingerman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Article Physiology

Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors

Chun-Chun Hsu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Article Physiology

Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing

Kenneth R. Olson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Article Chemistry, Analytical

Microplate-Based Colorimetric Detection of Free Hydrogen Sulfide

Artur P. Jarosz et al.

ANALYTICAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Regulation of Mercaptopyruvate Sulfurtransferase Activity Via Intrasubunit and Intersubunit Redox-Sensing Switches

Noriyuki Nagahara

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Myeloperoxidase: A Leukocyte-Derived Protagonist of Inflammation and Cardiovascular Disease

Claudia Nussbaum et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Biochemistry & Molecular Biology

H2S Is an Endothelium-Derived Hyperpolarizing Factor

Guanghua Tang et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

Guangdong Yang et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Biochemistry & Molecular Biology

Polysulfides Link H2S to Protein Thiol Oxidation

Romy Greiner et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Biotechnology & Applied Microbiology

Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells

Alireza Badiei et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

Katalin Modis et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes

Mitsuhiro Okamoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow

Liman Luo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca2+ concentrations

Yoshinori Mikami et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Pharmacology & Pharmacy

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

Khosrow Kashfi et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Sulfide inhibition of and metabolism by cytochrome c oxidase

Peter Nicholls et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2013)

Article Biochemistry & Molecular Biology

Reactivity and Dynamics of H2S, NO, and O2 Interacting with Hemoglobins from Lucina pectinata

Cacimar Ramos-Alvarez et al.

BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide

Li Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Pharmacology & Pharmacy

Inhibition by Hydrogen Sulfide of Rabbit Platelet Aggregation and Calcium Mobilization

Hiroyuki Nishikawa et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

Article Chemistry, Medicinal

Rhodamine-propargylic esters for detection of mitochondrial hydrogen sulfide in living cells

Xi Chen et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Pharmacology & Pharmacy

Treatment with hydrogen sulfide alleviates streptozotocin-induced diabetic retinopathy in rats

Yan-Fang Si et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles

S. Rashid et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Selectivity of commonly used pharmacological inhibitors for cystathionine synthase (CBS) and cystathionine lyase (CSE)

Antonia Asimakopoulou et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Modulation of arginine and asymmetric dimethylarginine concentrations in liver and plasma by exogenous hydrogen sulfide in LPS-induced endotoxemia

Seldag Bekpinar et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

High-fat diet stimulates hepatic cystathionine β-synthase and cystathionine γ-lyase expression

Sun-Young Hwang et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Endogenous CSE/H2S system mediates TNF--induced insulin resistance in 3T3-L1 adipocytes

Ci-You Huang et al.

CELL BIOCHEMISTRY AND FUNCTION (2013)

Article Cardiac & Cardiovascular Systems

Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis

Sarathi Mani et al.

CIRCULATION (2013)

Article Cardiac & Cardiovascular Systems

Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis

David J. Polhemus et al.

CIRCULATION-HEART FAILURE (2013)

Article Medical Laboratory Technology

Thiosulfate in urine as a facilitator in the diagnosis of prostate cancer for patients with prostate-specific antigen less or equal 10 ng/mL

Grazyna Chwatko et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2013)

Article Endocrinology & Metabolism

Hydrogen Sulfide Impairs Glucose Utilization and Increases Gluconeogenesis in Hepatocytes

Ling Zhang et al.

ENDOCRINOLOGY (2013)

Article Physiology

Treatment with exogenous hydrogen sulfide attenuates hyperoxia-induced acute lung injury in mice

Huai-Dong Li et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2013)

Article Pharmacology & Pharmacy

Hydrogen sulfide inhibits oxidative stress in lungs from allergic mice in vivo

Leticia R. Benetti et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Article Medicine, Research & Experimental

Hydrogen sulfide inhibits high-glucose-induced apoptosis in neonatal rat cardiomyocytes

Xiang Zhou et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Article Neurosciences

Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia

Marcelo Kwiatkoski et al.

EXPERIMENTAL NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

Polysulfides are possible H2S-derived signaling molecules in rat brain

Yuka Kimura et al.

FASEB JOURNAL (2013)

Article Biochemistry & Molecular Biology

Microbial regulation of host hydrogen sulfide bioavailability and metabolism

Xinggui Shen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Letter Cardiac & Cardiovascular Systems

17β-Estradiol attenuates atherosclerosis development: The possible role of hydrogen sulfide

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INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response

Li-Long Pan et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Letter Allergy

Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma

Junpei Saito et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

Pramod Kumar Yadav et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Cell Biology

Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts

Jingwei Sheng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)

Article Cell Biology

Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells

Zaid Altaany et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)

Article Neurosciences

Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes airway smooth muscle

Isabel Castro-Piedras et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Article Urology & Nephrology

Cystathionine γ-Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress

Eelke M. Bos et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Peripheral Vascular Disease

Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?

Priyadharshanan Ariyaratnam et al.

MICROVASCULAR RESEARCH (2013)

Review Biochemistry & Molecular Biology

Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases

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MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Developmental Biology

17β-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release

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MOLECULAR HUMAN REPRODUCTION (2013)

Article Medicine, Research & Experimental

Expression levels of endogenous hydrogen sulfide are altered in patients with allergic rhinitis

Se Jin Park et al.

LARYNGOSCOPE (2013)

Article Biochemistry & Molecular Biology

Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation

Thomas W. Miller et al.

MATRIX BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Physiological role of hydrogen sulfide and polysulfide in the central nervous system

Hideo Kimura

NEUROCHEMISTRY INTERNATIONAL (2013)

Article Obstetrics & Gynecology

Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats

Xiaoyan Zhu et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2013)

Meeting Abstract Biochemistry & Molecular Biology

Hydrogen sulfide inhibits human platelet aggregation

Zeki Ilkan et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Chemical foundations of hydrogen sulfide biology

Qian Li et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

Review Anesthesiology

Core myopathies and malignant hyperthermia susceptibility: a review

Robert P. Brislin et al.

PEDIATRIC ANESTHESIA (2013)

Article Multidisciplinary Sciences

Depolarizing Actions of Hydrogen Sulfide on Hypothalamic Paraventricular Nucleus Neurons

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PLOS ONE (2013)

Article Pharmacology & Pharmacy

Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels

A. Martelli et al.

PHARMACOLOGICAL RESEARCH (2013)

Article Multidisciplinary Sciences

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

Csaba Szabo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

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REPRODUCTIVE SCIENCES (2013)

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Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats

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Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans

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Alterations of Retinal Vasculature in Cystathionine-Beta-Synthase Mutant Mice, a Model of Hyperhomocysteinemia

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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

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Enhanced Reactive Adsorption of Hydrogen Sulfide on the Composites of Graphene/Graphite Oxide with Copper (Hydr)oxychlorides

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ACTA PHARMACOLOGICA SINICA (2012)

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Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats

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AGING MALE (2012)

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Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

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Endogenous H2S is required for hypoxic sensing by carotid body glomus cells

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Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress

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Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine

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The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability

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A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

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High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations

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The gasotransmitter hydrogen sulphide decreases Na+ transport across pulmonary epithelial cells

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BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS

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Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α

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Involvement of the endogenous hydrogen sulfide/Cav3.2 T-type Ca2+channel pathway in cystitis-related bladder pain in mice

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EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

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EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

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Induced and natural regulatory T cells in human cancer

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EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

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FREE RADICAL BIOLOGY AND MEDICINE (2012)

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Total Plasma Sulfide in Congestive Heart Failure

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Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

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MOLECULAR CELL (2012)

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LIPIDS IN HEALTH AND DISEASE (2012)

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PLACENTA (2012)

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Effects of Hydrogen Sulfide on Rat Pancreatic Stellate Cells

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PLOS ONE (2012)

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TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

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cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation

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Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Transplantation of Mesenchymal Stem Cells Preconditioned with Hydrogen Sulfide Enhances Repair of Myocardial Infarction in Rats

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TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis

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Hydrogen sulfide and cerebral microvascular tone in newborn pigs

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Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

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The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues

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Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic Tissue

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Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a

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CIRCULATION RESEARCH (2011)

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Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury

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EXPERIMENTAL PHYSIOLOGY (2011)

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Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells

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Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest

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FREE RADICAL BIOLOGY AND MEDICINE (2011)

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Measurement of plasma hydrogen sulfide in vivo and in vitro

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The Response of Caenorhabditis elegans to Hydrogen Sulfide and Hydrogen Cyanide

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Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium

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GYNECOLOGICAL ENDOCRINOLOGY (2011)

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Specificity Protein-1 as a Critical Regulator of Human Cystathionine γ-Lyase in Smooth Muscle Cells

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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine beta-synthase

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JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2011)

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A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

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JOURNAL OF CLINICAL INVESTIGATION (2011)

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Mechanisms of Action of the Gasotransmitter Hydrogen Sulfide in Modulating Contractile Activity of Longitudinal Muscle of Rat Ileum

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JOURNAL OF GASTROINTESTINAL SURGERY (2011)

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Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract

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Hydrogen Sulfide in the Rostral Ventrolateral Medulla Inhibits Sympathetic Vasomotor Tone through ATP-Sensitive K+ Channels

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Hydrogen Sulfide-Induced Dual Vascular Effect Involves Arachidonic Acid Cascade in Rat Mesenteric Arterial Bed

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Erectile Dysfunction and Risk of Cardiovascular Disease Meta-Analysis of Prospective Cohort Studies

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Common architecture of the flagellar type III protein export apparatus and F- and V-type ATPases

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Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye

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SCIENCE (2011)

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SCIENCE SIGNALING (2011)

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)

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Hydrogen sulfide in the RVLM and PVN has no effect on cardiovascular regulation

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FRONTIERS IN PHYSIOLOGY (2011)

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Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis

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AMERICAN JOURNAL OF NEPHROLOGY (2010)

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Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3β-dependent opening of mPTP

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Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels

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Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanism

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Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via KATP+ Channel Activation

Fernando Spiller et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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AMINO ACIDS (2010)

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ANESTHESIOLOGY (2010)

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Sulfide Binding Properties of Truncated Hemoglobins

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Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide

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A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood

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Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat

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Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21

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Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells

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H2S mediates O2 sensing in the carotid body

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Expert Review of Clinical Pharmacology (2010)

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

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BMC MEDICAL GENETICS (2009)

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Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus

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Hydrogen Sulphide Is Involved in Testosterone Vascular Effect

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EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

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Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

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H2S and HS- donor NaHS inhibits intracellular chloride channels

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GENERAL PHYSIOLOGY AND BIOPHYSICS (2009)

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HUMAN MUTATION (2009)

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JOINT BONE SPINE (2009)

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Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide

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JOURNAL OF BIOCHEMISTRY (2009)

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Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability ?

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Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys

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Initial Characterization of Hydrogen Sulfide Effects in Female Sexual Function

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Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

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Role of Hydrogen Sulfide in Hepatic Ischemia-Reperfusion-Induced Injury In Rats

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LIVER TRANSPLANTATION (2009)

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Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Hydrogen sulfide is an endogenous stimulator of angiogenesis

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Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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No facilitator required for membrane transport of hydrogen sulfide

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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The endogenous production of hydrogen sulphide in intrauterine tissues

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Comparison of the metabolic and ventilatory response to hypoxia and H2S in unsedated mice and rats

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RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2009)

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Hydrogen sulfide suppresses migration, proliferation and myofibroblast transdifferentiation of human lung fibroblasts

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PULMONARY PHARMACOLOGY & THERAPEUTICS (2009)

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H2S Signals Through Protein S-Sulfhydration

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SCIENCE SIGNALING (2009)

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Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

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WORLD JOURNAL OF GASTROENTEROLOGY (2009)

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Endogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-β-Synthase Mutant Mouse

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Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure

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Ischemia-reperfusion reduces cystathionine-β-synthase-mediated hydrogen sulfide generation in the kidney

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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

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Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells

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H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels

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Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling

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Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning

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Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis

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Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

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Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice

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Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes

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Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury

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Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria

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FEBS JOURNAL (2008)

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Hydrogen sulfide protects astrocytes against H2O2-induced neural injury via enhancing glutamate uptake

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FREE RADICAL BIOLOGY AND MEDICINE (2008)

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Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

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Production of the gaseous signal molecule hydrogen sulfide in mouse tissues

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Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction

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The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum

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Long-term hypothermia reduces infarct volume in aged rats after focal ischemia

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NEUROSCIENCE LETTERS (2008)

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Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?

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Hydrogen sulfide induces apoptosis in epithelial cells derived from human gingiva

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Surviving blood loss using hydrogen sulfide

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Hydrogen sulfide inhibits cell proliferation and induces cell cycle arrest via an elevated p21Cip1 level in Ca9-22 cells

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Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans

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Hydrogen sulfide enhances ulcer healing in rats

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Exogenous hydrogen sulfide induces functional inhibition and cell death of cytotoxic lymphocytes subsets

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Hydrogen sulfide mediates the vasoactivity of garlic

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Hydrogen sulfide enhances reducing activity in neurons:: Neurotrophic role of H2S in the brain?

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The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation

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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

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Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells

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Suspended animation-like state protects mice from lethal hypoxia

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Hydrogen sulfide inhibits human platelet aggregation

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Differentiated astrocytes acquire sensitivity to hydrogen sulfide that is diminished by the transformation into reactive astrocytes

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Human cystathionine β-synthase is a target for sumoylation

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Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization

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Hydrogen sulfide is a novel prosecretory neuromodulator in the guinea-pig and human colon

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Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide

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S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity

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LABORATORY INVESTIGATION (2006)

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Hydrogen sulphide - a novel mediator of inflammation?

L Li et al.

CURRENT OPINION IN PHARMACOLOGY (2006)

Article Pharmacology & Pharmacy

Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - a pilot study

B Srilatha et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

Article Chemistry, Multidisciplinary

Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats

SY Wu et al.

ACTA PHARMACOLOGICA SINICA (2006)

Article Pharmacology & Pharmacy

Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes

JS Bian et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Gastroenterology & Hepatology

The hyperdynamic circulation of chronic liver diseases: From the patient to the molecule

Y Iwakiri et al.

HEPATOLOGY (2006)

Review Physiology

Free radical biology and medicine: it's a gas, man!

William A. Pryor et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

Article Pharmacology & Pharmacy

Molecular mechanisms of hydrogen sulfide toxicity

Don H. Truong et al.

DRUG METABOLISM REVIEWS (2006)

Article Biochemistry & Molecular Biology

Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells

G Yang et al.

FASEB JOURNAL (2006)

Article Oncology

Evidence that hydrogen sulfide is a genotoxic agent

MS Attene-Ramos et al.

MOLECULAR CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Cystathionine β-synthase is enriched in the brains of Down's patients

A Ichinohe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Critical Care Medicine

Mechanisms of cell necrosis

C Szabó

CRITICAL CARE MEDICINE (2005)

Article Gastroenterology & Hepatology

Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis

MR Ebrahimkhani et al.

Article Critical Care Medicine

Endogenous hydrogen sulfide in patients with COPD

YH Chen et al.

Article Pharmacology & Pharmacy

Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia

M Collin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2005)

Article Biochemistry & Molecular Biology

Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide

X Leschelle et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2005)

Article Biotechnology & Applied Microbiology

Identification and functional analysis of Escherichia coli cysteine desulfhydrases

N Awano et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)

Article Pharmacology & Pharmacy

Phenazopyridine-induced sulfhemoglobinemia

AS Gopalachar et al.

ANNALS OF PHARMACOTHERAPY (2005)

Article Biochemical Research Methods

Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues

JE Doeller et al.

ANALYTICAL BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver

K Fujii et al.

ANTIOXIDANTS & REDOX SIGNALING (2005)

Article Multidisciplinary Sciences

H2S induces a suspended animation-like state in mice

E Blackstone et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

L Li et al.

FASEB JOURNAL (2005)

Article Hematology

Gene expression profiling in polycythaemia vera:: overexpression of transcription factor NF-E2

PS Goerttler et al.

BRITISH JOURNAL OF HAEMATOLOGY (2005)

Article Pharmacology & Pharmacy

Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle

R Patacchini et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

Article Biochemistry & Molecular Biology

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

M Whiteman et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Anatomy & Morphology

Cystathionine beta-synthase deficiency affects mouse endochondral ossification

K Robert et al.

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY (2005)

Review Geriatrics & Gerontology

The role of homocysteine in multisystem age-related problems: A systematic review

HK Kuo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)

Review Biochemistry & Molecular Biology

Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

R Banerjee et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)

Article Biochemistry & Molecular Biology

Hydrogen sulfide protects neurons from oxidative stress

Y Kimura et al.

FASEB JOURNAL (2004)

Article Biochemistry & Molecular Biology

Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension

QY Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Multidisciplinary Sciences

A genomewide oscillation in transcription gates DNA replication and cell cycle

RR Klevecz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Pharmacology & Pharmacy

Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders

M Gopalakrishnan et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2004)

Article Biochemistry & Molecular Biology

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

The role of thiols and disulfides in platelet function

DW Essex

ANTIOXIDANTS & REDOX SIGNALING (2004)

Article Biochemistry & Molecular Biology

Abnormal lipid metabolism in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia

K Namekata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

DD Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Cystathionine β-synthase:: Structure, function, regulation, and location of homocystinuria-causing mutations

EW Miles et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Physiology

Urinary bladder contraction and relaxation: Physiology and pathophysiology

KE Andersson et al.

PHYSIOLOGICAL REVIEWS (2004)

Article Biochemistry & Molecular Biology

A point mutation in a silencer module reduces the promoter activity for the human mercaptopyruvate sulfurtransferase

N Nagahara et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2004)

Article Biochemistry & Molecular Biology

Hydrogen sulfide induces calcium waves in astrocytes

Y Nagai et al.

FASEB JOURNAL (2004)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats

YQ Cheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Review Nutrition & Dietetics

Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine

MH Stipanuk

ANNUAL REVIEW OF NUTRITION (2004)

Review Physiology

Long-term potentiation and memory

MA Lynch

PHYSIOLOGICAL REVIEWS (2004)

Article Medicine, General & Internal

Homocysteine levels and the risk of osteoporotic fracture

JBJ van Meurs et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Pharmacology & Pharmacy

Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder

R Patacchini et al.

BRITISH JOURNAL OF PHARMACOLOGY (2004)

Article Biochemistry & Molecular Biology

Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF

J Angulo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Review Multidisciplinary Sciences

Cell migration: Integrating signals from front to back

AJ Ridley et al.

SCIENCE (2003)

Review Biochemistry & Molecular Biology

Endosymbiosis and the design of eukaryotic electron transport

S Berry

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2003)

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Modulation of endogenous production of H2S in rat tissues

WM Zhao et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2003)

Review Clinical Neurology

Homocysteine and Alzheimer's disease

MS Morris

LANCET NEUROLOGY (2003)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α-induced targeted proteolysis of cystathionine β-synthase modulates redox homeostasis

CG Zou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Gastroenterology & Hepatology

Antro-fundic dysfunctions in functional dyspepsia

MP Caldarella et al.

GASTROENTEROLOGY (2003)

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The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats

CY Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Dentistry, Oral Surgery & Medicine

Relationship between periodontal pocket sulfide levels and subgingival species

G Torresyap et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2003)

Article Biochemistry & Molecular Biology

Hormonal regulation of cystathionine β-synthase expression in liver

S Ratnam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Cardiac & Cardiovascular Systems

H2S-induced vasorelaxation and underlying cellular and molecular mechanisms

WM Zhao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)

Article Neurosciences

Hydrogen sulfide as a neuromodulator

H Kimura

MOLECULAR NEUROBIOLOGY (2002)

Article Dentistry, Oral Surgery & Medicine

Gastrointestinal diseases and halitosis:: association of gastric Helicobacter pyloriinfection

K Hoshi et al.

INTERNATIONAL DENTAL JOURNAL (2002)

Article Biochemistry & Molecular Biology

Brain hydrogen sulfide is severely decreased in Alzheimer's disease

K Eto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

What is the role of nitric oxide in murine and human host defense against tuberculosis? Current knowledge

ED Chan et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

WM Zhao et al.

EMBO JOURNAL (2001)

Article Medical Laboratory Technology

Hyperhomocysteinaemia and human reproduction

WLDM Nelen

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2001)

Article Medical Laboratory Technology

Homocysteine in postmenopausal women and the importance of hormone replacement therapy

V Mijatovic et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2001)

Article Cardiac & Cardiovascular Systems

Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine β-synthase-deficient mice

S Dayal et al.

CIRCULATION RESEARCH (2001)

Article Biochemistry & Molecular Biology

Sulfide oxidation coupled to ATP synthesis in chicken liver mitochondria

R Yong et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2001)

Article Anesthesiology

Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia

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BRITISH JOURNAL OF ANAESTHESIA (2001)

Review Microbiology

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CG Kurland et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2000)

Article Pharmacology & Pharmacy

A standardized procedure for using human corpus cavernosum strips to evaluate drug activity

V Mirone et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)

Article Pharmacology & Pharmacy

Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor

SA Buckner et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2000)

Article Biochemistry & Molecular Biology

Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor

H Kimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)