期刊
JOURNAL OF APPLIED PHYCOLOGY
卷 29, 期 1, 页码 521-529出版社
SPRINGER
DOI: 10.1007/s10811-016-0929-x
关键词
Low molecular fucoidans; UVdamage; TGF beta RII; MMP genes
资金
- National Science Council of the Executive Yuan, Taiwan [NSC 104-2320-B-034-003, NSC 105-2320-B-034-001]
Fucoidans have been long used as a food supplement due to their diverse pharmacological effects on human health. Low molecular weight fucoidan (LF) is a common form of fucoidans that has been shown to have enhanced biological activity. In the present study, fucoidans were extracted from the brown alga Sargassum hemiphyllum and enzyme-hydrolyzed into low and high molecular weight fucoidans (HF). The skin protective effects of LF, HF, and other fucoidans derivatives against ultraviolet B (UVB) damage were determined by measuring the expression levels of matrix metalloproteinase genes encoding collagenases (MMP-1, MMP-2, MMP-8, MMP-9, MMP-13), transforming growth factor beta receptor II (TGF beta RII), and type I procollagen. The results show that LF protects against UVB damage to the skin by inhibiting UVB-induced transcription factor activator protein-1 (AP-1)-stimulated transcription of MMP genes encoding collagenases (MMP-1, MMP-8, and MMP-13) and increasing TGF beta RII mRNA levels to prevent the loss of TGF beta RII that occurs during UVB-induced collagen degradation. Moreover, this study reveals that the biological properties of fucoidans are highly dependent on the fucose content, sulfate content, and molecular weight.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据