期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 67, 期 12, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1361-6560/ac6e24
关键词
deep learning; magnetic particle imaging; spatial resolution; superparamagnetic iron oxide nanoparticles
资金
- National Key Research and Development Program of China [2017YFA0700401]
- National Natural Science Foundation of China [62027901, 81827808, 81527805, 81571836, 81671851, KKA309004533, 81227901]
- CAS Youth Innovation Promotion Association [2018167]
- CAS Key Technology Talent Program
- Project of High-Level Talents Team Introduction in Zhuhai City [Zhuhai HLHPTP201703]
This study proposes a deep-learning approach to improve the spatial resolution of magnetic particle imaging (MPI) by fusing a dual-sampling convolutional neural network (FDS-MPI). The results from simulation and phantom experiments demonstrate that the FDS-MPI model can improve the spatial resolution by a factor of two, which could facilitate the future preclinical application of medical imaging modalities.
Objective. Magnetic particle imaging (MPI) is a new medical, non-destructive, imaging method for visualizing the spatial distribution of superparamagnetic iron oxide nanoparticles. In MPI, spatial resolution is an important indicator of efficiency; traditional techniques for improving the spatial resolution may result in higher costs, lower sensitivity, or reduced contrast. Approach. Therefore, we propose a deep-learning approach to improve the spatial resolution of MPI by fusing a dual-sampling convolutional neural network (FDS-MPI). An end-to-end model is established to generate high-spatial-resolution images from low-spatial-resolution images, avoiding the aforementioned shortcomings. Main results. We evaluate the performance of the proposed FDS-MPI model through simulation and phantom experiments. The results demonstrate that the FDS-MPI model can improve the spatial resolution by a factor of two. Significance. This significant improvement in MPI could facilitate the preclinical application of medical imaging modalities in the future.
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