Polar Fluctuations Lead to Extensile Nematic Behavior in Confluent Tissues

How can a collection of motile cells, each generating contractile nematic stresses in isolation, become an extensile nematic at the tissue level? Understanding this seemingly contradictory experimental observation, which occurs irrespective of whether the tissue is in the liquid or solid states, is not only crucial to our understanding of diverse biological processes, but is also of fundamental interest to soft matter and many body physics. Here, we resolve this cellular to tissue level disconnect in the small fluctuation regime by using analytical theories based on hydrodynamic descriptions of confluent tissues, in both liquid and solid states. Specifically, we show that a collection of microscopic constituents with no inherently nematic extensile forces can exhibit active extensile nematic behavior when subject to polar fluctuating forces. We further support our findings by performing cell level simulations of minimal models of confluent tissues.

Automated summary

A collection of motile cells, each generating contractile nematic stresses in isolation, can exhibit extensile nematic behavior at the tissue level, which seems contradictory. Understanding this phenomenon is crucial in biology and has fundamental significance in soft matter and many body physics.