4.7 Article

Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

The role of patient-derived ovarian cancer organoids in the study of PARP inhibitors sensitivity and resistance: from genomic analysis to functional testing

Mengyu Tao et al.

Summary: PARPi has been incorporated into the standard of care for EOC patients, with NGS genomic analysis providing crucial information for predicting PARPi response. Despite limitations, a combination of NGS and functional assays using PDOs can enhance efficient screening of EOC patients suitable for PARPi.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Oncology

Understanding and overcoming resistance to PARP inhibitors in cancer therapy

Mariana Paes Dias et al.

Summary: PARP inhibitors have shown success in treating certain cancer patients, but most will develop resistance to these inhibitors, prompting the need for novel treatment strategies. Current research efforts are focused on finding ways to overcome resistance mechanisms.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Cell & Tissue Engineering

Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models

Nina Maenhoudt et al.

STEM CELL REPORTS (2020)

Review Biochemistry & Molecular Biology

PARP inhibitor resistance: the underlying mechanisms and clinical implications

He Li et al.

MOLECULAR CANCER (2020)

Review Oncology

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

Patrick G. Pilie et al.

CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

Review Oncology

State-of-the-art strategies for targeting the DNA damage response in cancer

Patrick G. Pilie et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

Acetylation blocks DNA damage-induced chromatin ADP-ribosylation

Glen Liszczak et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Oncology

Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes

Darren R. Hodgson et al.

BRITISH JOURNAL OF CANCER (2018)

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

Devanjali Dutta et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Multidisciplinary Sciences

Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri et al.

NATURE (2016)

Review Cell Biology

The Fanconi anaemia pathway: newyplayers and new functions

Raphael Ceccaldi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Medicine, General & Internal

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

M. R. Mirza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib

Sebastian Gamba et al.

ANTI-CANCER DRUGS (2015)

Article Anatomy & Morphology

PAX2 and PAX8 Reliably Distinguishes Ovarian Serous Tumors From Mucinous Tumors

Min Wang et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2015)

Article Multidisciplinary Sciences

Integrated analysis of germline and somatic variants in ovarian cancer

Krishna L. Kanchi et al.

NATURE COMMUNICATIONS (2014)

Article Oncology

Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor

Louise J. Barber et al.

JOURNAL OF PATHOLOGY (2013)

Article Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai et al.

CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna et al.

GENOME RESEARCH (2010)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Article Medicine, General & Internal

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.

Peter C. Fong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Genetics & Heredity

Listening to silence and understanding nonsense: Exonic mutations that affect splicing

L Cartegni et al.

NATURE REVIEWS GENETICS (2002)