The missing heritability in pharmacogenomics: role of NFIB and other factors

it is most likely that genetic variation in a multitude of different polymorphic genes is responsible, where the gene products in one way or another influence the pharmacokinetics and pharmacodynamics of different drugs by many different mechanisms and thereby contribute to the phenotypic variability observed.

Automated summary

Genetic variation in polymorphic genes plays a crucial role in influencing the pharmacokinetics and pharmacodynamics of different drugs through various mechanisms, contributing to the observed phenotypic variability.