期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 56, 期 1, 页码 29-37出版社
SPRINGER
DOI: 10.1007/s11094-022-02597-z
关键词
anticancer; anti-proliferative; piperazine; heterocyclic compounds; structure-activity relationship
The article explores the anticancer applications of piperazine-containing hybrid heterocycles, highlighting the central role of piperazine framework in synthetic and natural compounds with a wide range of biological activities. Several patents approved for anticancer activity of piperazine heterocycles are also discussed.
Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health afflictions worldwide. Molecular hybridization is related to a combination of two or more pharmacophores of bioactive frames which generate a single molecular structure with enhanced activity. Previous studies described the piperazine framework as a central structure in numerous synthetic and natural compounds, showing a wide range of biological activities. Here, we review, highlight and discuss a detailed account of the anticancer applications of some important piperazine-containing hybrid heterocycles; we have also included several patents approved for the anticancer activity of piperazine heterocycles.
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