1,3,4-Thiadiazole Scaffold: Anti-Microbial Agents

1,3,4-Thiadiazole moiety has various biological activities including anticancer, antidiabetic, antihypertensive, anti-inflammatory, antiviral, and anti-microbial. Some drugs with thiadiazole scaffold, e.g., sulfamethoxazole, acetazolamide, and butazolamide produce diverse biological action. From the in-dept literature review, some structural modifications in the 1,3,4-thiadiazole ring have resulted in highly effective and less toxic compounds and have good prospects as anti-microbial agents. The present review considers some structural modifications of thiadiazole scaffold that can be beneficial for anti-microbial activity.

Automated summary

The 1,3,4-thiadiazole moiety exhibits a variety of biological activities and can be modified to produce more effective and less toxic compounds with potential as antimicrobial agents.