Recent research progress and outlook in agricultural chemical discovery based on quinazoline scaffold

The discovery of new scaffolds and targets for pesticides is still a huge challenge facing the sustainable development of modern agriculture. In recent years, quinazoline derivatives have achieved great progress in drug discovery and have attracted great attention. Quinazoline is a unique bicyclic scaffold with a variety of biological activities, which increases the possibilities and flexibility of structural modification, showing enormous appeal in the discovery of new pesticides. Therefore, the agricultural biological activities, structure-activity relationships (SAR), and mechanism of action of quinazoline derivatives in the past decade were reviewed systematically, with emphasis on SAR and mechanism. Then, we prospected the application of the quinazoline scaffold as a special structure in agricultural chemical discovery, hoping to provide new ideas for the rational design and mechanism of novel quinazoline agricultural chemicals in the future.

Automated summary

The discovery of new scaffolds and targets for pesticides is a major challenge for sustainable agricultural development. Quinazoline derivatives have made significant progress in drug discovery and attracted great attention. Quinazoline, as a unique bicyclic scaffold, offers possibilities and flexibility for structural modification, making it an appealing candidate for discovering new pesticides. This article systematically reviews the agricultural biological activities, structure-activity relationships (SAR), and mechanism of action of quinazoline derivatives in the past decade, with a focus on SAR and mechanism. The authors also provide insights into the application of quinazoline scaffold in agricultural chemical discovery, aiming to inspire the rational design and mechanism of novel quinazoline agricultural chemicals in the future.