Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress

Article Pharmacology & Pharmacy

Abscisic acid ameliorates oxidative stress, inflammation, and apoptosis in thioacetamide-induced hepatic fibrosis by regulating the NF-κB signaling pathway in mice

Xueyan Chen et al.

Summary: The study showed that ABA can protect against liver fibrosis induced by TAA in vivo by inhibiting apoptosis and inflammatory responses, suggesting its potential as a therapeutic agent for preventing liver damage.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Chemistry, Medicinal

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Aurelia Magdalena Pisoschi et al.

Summary: This review paper examines the chemistry of oxidative stress mitigation by antioxidants, highlighting the crucial role of balancing pro-oxidant and antioxidant species. It discusses the association between oxidative stress and various diseases, elucidating the types, mechanisms, and defense strategies of antioxidants.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute

Keita Shibata et al.

Summary: The study showed that SMTP-7 dose-dependently improved renal function, reduced renal tubule damage, and exhibited anti-inflammatory and antioxidant activities in AKI mice, indicating its potential as a medicinal compound for AKI treatment.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE

George A. Robinson et al.

Summary: Through serum metabolomic analysis and RNA sequencing, two unique lipoprotein profile groups were identified in JSLE patients, with high ApoB:ApoA1 ratio serving as a potential biomarker of increased cardiometabolic risk and worse clinical outcomes. The high ApoB:ApoA1 ratio in JSLE patients was associated with increased CD8+ T-cell frequencies and genes related to atherosclerosis.

EBIOMEDICINE (2021)

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Review Environmental Sciences

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Ruirui Guan et al.

Summary: Phytochemicals found in plant-based diets have beneficial effects on reducing oxidative stress and preventing various diseases, suggesting a diet rich in fruits, vegetables, and grains.

CHEMOSPHERE (2021)

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Article Biochemistry & Molecular Biology

Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets

Chrishan J. A. Ramachandra et al.

Summary: Cardiac hypertrophy is an adaptive change of the heart to maintain normal function, with oxidative stress identified as a critical inducer. In addition to traditional mediators of oxidative stress, metabolic disturbances, mitochondrial dysfunction, inflammation, dysregulated autophagy, and protein homeostasis also contribute to cardiac pathophysiology through oxidative stress mechanisms. Novel therapeutic targets and repurposed drugs aimed at counteracting oxidative stress have shown promise in attenuating cardiac hypertrophy.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Medicine, General & Internal

Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability

Zhaohua Cai et al.

Summary: SENP3 is highly expressed in vascular smooth muscle cells during vascular remodeling, promoting cell proliferation and migration through interaction with beta-catenin and inhibition of its degradation, suggesting a crucial role as a redox sensor and mediator in vascular remodeling.

EBIOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Angiotensin-(3-7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways

Yonglin Zhang et al.

Summary: The study found that Angiotensin (Ang)-(3-7) could alleviate cardiac remodeling by inhibiting the cAMP/PKA and PI3K/Akt signaling pathways to reduce hypertrophy of NRCMs and fibrosis of NRCFs, respectively.

AMINO ACIDS (2021)

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Article Cell Biology

Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity

Xin Zhang et al.

Summary: Proteasomal activity is compromised in diabetic hearts, leading to proteotoxic stresses and cardiac dysfunction. Osteocrin (OSTN) plays a crucial role in diabetic cardiomyopathy (DCM) by maintaining the dephosphorylation state of protein kinase B/FOXO1 to alleviate cardiac injury. Experimental evidence demonstrates that OSTN can restore PKB-dependent proteasomal function, providing protective effects against diabetic heart damage.

CELL DEATH & DISEASE (2021)

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Review Pharmacology & Pharmacy