4.3 Review

Neutrophils: Friend or foe in Filariasis?

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Summary: This review summarizes over a century of research on onchocerciasis, also known as river blindness, and its control. It discusses the history, milestones, current state, and future perspectives of the disease, highlighting successful control and elimination efforts in certain countries. It contributes to a deeper comprehension of this tissue-dwelling filaria disease and may aid in efforts to control and eliminate other filarial infections.

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Summary: Filariae are parasitic nematodes that are transmitted by vectors such as mosquitoes, and are endemic in tropical and subtropical regions worldwide. Efforts to control and eliminate filarial diseases have been ongoing since the 1970s, focusing on mass drug administration and vector control strategies. The goal is to reduce transmission and ultimately eliminate filarial diseases as a public health concern.

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Summary: Eosinophils have been implicated in both protective and pathogenic immune responses to helminth infection since their earliest descriptions. However, their precise role in helminth infection remains incompletely understood due to factors such as the heterogeneity of parasites, complexity in host immune response, and the pleiotropic functions of eosinophils. This review examines the consequences of helminth-associated eosinophilia in terms of protective immunity, pathogenesis, and immunoregulation.

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Summary: Neutrophils are the body's first line of defense against invading pathogens, but recent research has shown that they have much more sophisticated and diverse functions than previously thought. Studies focusing on the role of neutrophils in helminth infections have highlighted their key role in the immune system, even during type 2 responses.

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Basophils in antihelminth immunity

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Summary: Basophils are commonly associated with helminth infections and are known to contribute to immune responses by promoting optimal type 2 T helper cell reactions. However, recent studies have revealed that their effector functions are diverse and parasite-specific. Additionally, basophils can also regulate inflammation and maintain tissue integrity in helminth-infected individuals.

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Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release

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Characterization of apyrase-like activity in Ochlerotatus triseriatus, Ochlerotatus hendersoni, and Aedes aegypti

HE Reno et al.

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Treatment strategies underpinning the global programme to eliminate lymphatic filariasis

JO Gyapong et al.

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Neutrophil extracellular traps kill bacteria

V Brinkmann et al.

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A Hoerauf et al.

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AV Saint Andre et al.

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