期刊
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
卷 36, 期 5, 页码 665-672出版社
WILEY
DOI: 10.1111/ppe.12876
关键词
BMC; BMD; bone mineral content; bone mineral density; sibling study; very low birthweight; VLBW; VLBW adult
资金
- Doctoral Programme in Clinical Research, University of Helsinki
- Academy of Finland [274794, 315680]
- European Commission [733280]
- Finnish Foundation for Pediatric Research
- Finska Lakaresallskapet
- Juho Vainio Foundation
- Paulo Foundation
- Paivikki and Sakari Sohlberg Foundation
- Jalmari and Rauha Ahokas Foundation
- Novo Nordisk Foundation
- Einar and Karin Stroem Foundation
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Yrjo Jahnsson Foundation
Individuals born with very low birthweight have lower bone mineral density and content compared to term-born siblings, partially explained by their smaller body size, but genetic or environmental factors also play a role.
Background Children and adults born very low birthweight (VLBW, <1500 g) at preterm gestations have lower bone mineral density (BMD) and/or bone mineral content (BMC) than those born at term, but causality remains unknown. Objectives Our aim was to assess BMD and BMC in adults born at VLBW in a sibling comparison setting to account for shared genetic and environmental confounders. Methods We conducted a cohort study of 77 adults born VLBW and 70 same-sex term-born siblings at mean age of 29 years. The primary outcome variables were BMD Z-scores, and BMC, of the femoral neck, lumbar spine, and whole body, measured using dual-energy X-ray absorptiometry. We analysed data by linear mixed models. Results The VLBW adults had a 0.25 (95% CI 0.02, 0.47) Z-score unit lower femoral neck BMD, and 0.35 (95% CI 0.16, 0.54) grams lower femoral neck BMC than their term-born siblings, after adjustment for sex, age, and maternal smoking. Additional adjustment for adult body size attenuated the results. Lumbar spine, and whole body BMC were also lower in the VLBW group. Conclusions Individuals born at VLBW had lower BMC values at all three measurement sites, as well as lower femoral neck BMD Z-scores, compared to term-born siblings, partly explained by their smaller adult body size, but the differences were smaller than those reported previously with unrelated controls. This suggests that genetic or environmental confounders explain partly, but not exclusively, the association between preterm VLBW birth and adult bone mineralisation.
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