期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/9749461
关键词
-
类别
资金
- Key Research and Development Plan of Shaanxi Province [2021SF-379]
- research plan of Shaanxi Administration of Traditional Chinese Medicine [2021-GJ-JC005]
Quercetin, extracted from tea, onions, and apples, has a neuroprotective effect on experimental ischemic stroke. This systematic review and meta-analysis found that quercetin significantly improved neurological function score and reduced infarct volume. It also alleviated blood-brain barrier permeability and brain water content. The mechanisms of quercetin against focal cerebral ischemia involve antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. Although the effect size may be overestimated due to study quality and publication bias, quercetin shows potential as a neuroprotective agent for human ischemic stroke.
Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) (P < 0.05), and twelve studies reported a significant effect on reducing infarct volume (P < 0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据