Apatinib Induces Ferroptosis of Glioma Cells through Modulation of the VEGFR2/Nrf2 Pathway

Article Biochemistry & Molecular Biology

HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

You Wu et al.

Summary: This study demonstrated that HMGB1 regulates glucose-induced ferroptosis via Nrf2 pathway in mesangial cells, suggesting its therapeutic potential in diabetic kidney disease.

BIOSCIENCE REPORTS (2021)

添加到收藏夹

Article Oncology

Apatinib induced ferroptosis by lipid peroxidation in gastric cancer

Liying Zhao et al.

Summary: In summary, apatinib induces lipid peroxidation through GPX4 mediated by SREBP-1a, leading to the ferroptosis of gastric cancer cells, including multi-drug resistant ones.

GASTRIC CANCER (2021)

添加到收藏夹

Article Chemistry, Medicinal

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

Gai Gao et al.

Summary: The study found that dehydroabietic acid (DA) can improve nonalcoholic fatty liver disease (NAFLD), reduce the accumulation of lipid peroxides, inhibit hepatic ferroptosis, and reduce the accumulation of reactive oxygen species by activating the Nrf2 antioxidant response pathway.

JOURNAL OF NATURAL MEDICINES (2021)

添加到收藏夹

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Oncology