期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.2c00065
关键词
benzylic monochlorination; photochemistry; sensitizer; flow chemistry; DoE
A selective photochemical monochlorination of 2-fluorotoluene has been developed using a continuous flow process, optimizing key reaction parameters to minimize the formation of dichlorinated by-products. The reaction has been successfully scaled up on a multi decagram scale.
A selective photochemical monochlorination of 2-fluorotoluene has been developed by a continuous flow process using two different flow reactors, one for the tuning of the conditions and the second one for the scale-up. The key reaction parameters were optimized using one-factor-at-a-time and design of experiment methods, with the goal of minimizing the formation of the dichlorinated by-product. This transformation has been performed on a multi decagram scale.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据