期刊
ORGANIC LETTERS
卷 24, 期 22, 页码 4093-4098出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01731
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资金
- NSFC [21871178, 22071149, 22122104, 22193010, 21933004]
- STCSM [19JC1430100]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
An enantioselective selenocyclization of 1,1-disubstituted alkenes was achieved for the first time using a novel combination of a chiral BINAM-derived sulfide and an achiral Lewis acid. Various selenium-containing 4H-3,1-benzoxazines, which are found in many medicinally relevant molecules, were synthesized in moderate to good yields and good to excellent enantioselectivities. The reaction also facilitated the construction of tetrasubstituted carbon stereocenters.
An enantioselective selenocyclization of 1,1-disubstituted alkenes was achieved for the first time, which is enabled by a novel combination of a chiral BINAM-derived sulfide and an achiral Lewis acid. Various seleniumcontaining 4H-3,1-benzoxazines, which are widely present in a range of medicinally relevant molecules, were readily obtained in moderate to good yields and good to excellent enantioselectivities. A series of tetrasubstituted carbon stereocenters were facilely constructed.
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