期刊
ORGANIC LETTERS
卷 24, 期 11, 页码 2214-2219出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00563
关键词
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资金
- National Natural Science Foundation of China [22071175]
- Yanshan University High-end Talents Project [BL18014]
- Department of Education of Hebei Province Foundation [QN2019220]
In this study, the combined use of BnS(O)CF3/BnSe(O)CF3 with Tf2O was employed to achieve the efficient synthesis of 4-(trifluoromethylthio/ trifluoromethylseleno)isocoumarins from 2-alkynylbenzoates, which is of significance in biological research. The mechanistic pathway was proposed to involve interrupted Pummerer reactions followed by a concerted trifluoromethylthiolation/selenolation and lactonization process.
The combined use of BnS(O)CF3/BnSe(O)CF3 with Tf2O as SCF3/SeCF3 reagents was implemented to realize an efficient synthesis of biologically interesting 4-(trifluoromethylthio/ trifluoromethylseleno)isocoumarins from 2-alkynylbenzoa tes. The mechanistic pathway was postulated to involve formation of the electrophilic SCF3/SeCF3 species via interrupted Pummerer reactions followed by a concerted trifluoromethylthiolation/selenolation and lactonization process.
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