期刊
ORGANIC LETTERS
卷 24, 期 11, 页码 2264-2268出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00795
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资金
- National Natural Science Foundation of China [NSF22061038, 22067018]
- Gansu Province Science Foundation [21JR7RA133]
- Gansu High Education Innovation Fund Project [2021B-080]
- Northwest Normal University Young Scholars Research Capacity Improvement Program [NWNU-LKQN-18-6]
An iron(II)-catalyzed bisphosphorylation cascade cycloisomerization of readily accessible gamma-hydroxy ynones and diphenylphosphine oxides is reported. This strategy provides a variety of valuable polysubstituted bisphosphorylated dihydrofuran scaffolds via the construction of two C-P bonds and one C-O bond within a single procedure. The developed reaction system demonstrates good functional group compatibilities with considerably low catalyst consumption, and can be further scaled up to gram quantities in satisfactory yields.
An iron(II)-catalyzed bisphosphorylation cascade cycloisomerization of readily accessible gamma-hydroxyl ynones and diphenylphosphine oxides is described. This strategy provides a variety of valuable polysubstituted bisphosphorylated dihydrofuran scaffolds via the construction of two C-P bonds and one C-O bond within a single procedure. This developed reaction system demonstrates good functional group compatibilities with considerably low catalyst consumption (as low as 1%), which could be further scaled up to gram quantities in satisfactory yields.
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