期刊
ORGANIC LETTERS
卷 24, 期 13, 页码 2567-2572出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00808
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This study reports a kinetically controllable strategy for the construction of challenging nine-membered carbocycles. The Pd-catalyzed decarboxylative procedure uses vinyl methylene cyclic carbonates as the C5-dipole and allylidenemalononitriles as C4-building blocks. The protocol features user-friendly operations with controllable regioselectivity and produces CO2 as the sole byproduct. The formation of synthetically valuable and thermodynamically favored seven-membered carbocycles was also investigated.
A kinetically controllable strategy toward the construction of otherwise challenging nine-membered carbocycles is reported. This Pd-catalyzed decarboxylative procedure utilizes vinyl methylene cyclic carbonates as the C5-dipole and allylidenemalononitriles as C4-building blocks. The protocol features user-friendly operations with controllable regioselectivity and generates CO2 as the sole byproduct. The formation of synthetically valuable and thermodynamically favored seven-membered carbocycles was also investigated.
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