期刊
ORGANIC LETTERS
卷 24, 期 11, 页码 2208-2213出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00516
关键词
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资金
- National Natural Science Foundation of China [81973176, 22171294, 92056201]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06Y337]
- Guangdong Provincial Key Laboratory of Chiral Molecule
- Natural Science Foundation of Guangdong Province [2021A1515010401, 2019B030301005]
This study reports two DNA-compatible reactions with alkenes and diazo compounds, providing hydroalkylation and cyclopropanation products in moderate to excellent yields. These transformations not only offer new access to C(sp3)-C(sp3) bond formation in DELs with excellent functional group tolerance, but also represent practical ligation methods to introduce functionalized molecules into DNA.
To explore potential chemical space using DNA-encoded library (DEL) technology, the development of various types of robust DNA-compatible reactions is urgently needed. Diazo compounds, which serve as valuable building blocks and important synthons in synthetic chemistry, have been rarely applied in DEL synthesis, probably because of their potential modifications of the bases and phosphate backbone of DNA. Herein we report two cases of DNA-compatible reactions with alkenes and diazo compounds, providing corresponding hydroalkylation and cyclopropanation products in moderate to excellent yields. Notably, these transformations not only provide new access to C(sp3)-C(sp3) bond formation in DELs with excellent functional group tolerance but also represent practical ligation methods to introduce functionalized molecules into DNA.
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