期刊
ORGANIC LETTERS
卷 24, 期 11, 页码 2232-2237出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00609
关键词
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资金
- National Natural Science Foundation of China [21971001, 22101002, 21701001]
- Fonds der ChemischenIndustrie
A site-selective cyclopropanation of N-heterocyclic carbene (NHC)-borane complexes via photochemical carbene transfer reactions is reported in this study. The approach can also be extended to the difunctionalization of NHC-boranes through cyclopropanation and the B-H insertion reaction. Further investigations on photochemical continuous-flow applications and synthetic transformations demonstrate the utility of the method. Theoretical calculations and control experiments were conducted to explain the observed selectivity.
Herein we report a site-selective cyclopropanation of N-heterocyclic carbene (NHC)-borane complexes via photochemical carbene transfer reactions. By subtle changes to the reaction conditions, this approach can be further extended toward the difunctionalization of NHC-boranes via cyclopropanation and the B-H insertion reaction. Further investigations in photochemical continuous-flow applications and synthetic transformations proved the utility of the method. Theoretical calculations and control experiments were performed to explain the observed selectivity.
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