期刊
ORGANIC LETTERS
卷 24, 期 9, 页码 1786-1790出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00140
关键词
-
资金
- National Key R&D Program of China [2019YFE0109200]
- NSFC [U1702286]
- Ling-Jun Scholars [202005AB160003]
- NSF of Yunnan Province [2019FY003010, 2019FI018]
- IRTSTYN
- US National Science Foundation [CHE-1902509]
This study introduces a transition-metal-free method using superelectron-donor for the rapid construction of isoquinolines through a tandem reaction, demonstrating high yields and good functional group tolerance of the method. Additionally, a gram scale synthesis confirms the scalability of the approach.
Herein is introduced the application of superelectron-donor(SED) 2-azaallyl anions in a tandem reduction/radical cyclization/radical coupling/aromatization protocol that enables the rapid construction of isoquinolines. The value of this transition-metal-free method is highlighted by the wide range of isoquinoline ethyl amines prepared with good functional group tolerance and yields. An operationally simple gram scale synthesis is also conducted, confirming the scalability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据