期刊
ORGANIC LETTERS
卷 24, 期 19, 页码 3466-3470出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01043
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资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [EXC-2033-390677874 -RESOLV]
In the presence of a [Ru(p-cymene)Cl-2](2)/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C-H functionalization proceeds with high yields and (Z/E)-ratios, and it can tolerate a wide range of functional groups. Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation and it shows orthogonal stereoselectivity.
In the presence of a [Ru(p-cymene)Cl-2](2)/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C-H functionalization proceeds in high yields of up to 94% and (Z/E)-ratios of up to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity.
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