4.8 Article

In Situ Alkyl Radical Recycling-Driven Decoupled Electrophotochemical Deamination

期刊

ORGANIC LETTERS
卷 24, 期 19, 页码 3471-3476

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01022

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资金

  1. National Natural Science Foundation of China [22171154, 21801144]
  2. Youth Innovative Talents Recruitment and Cultivation Program of Shandong Higher Education
  3. Natural Science Foundation of Shandong Province [ZR2020QB114, ZR2020QB008]
  4. Jinan Science & Technology Bureau [2021GXRC080]
  5. Foundation of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences) [ZZ20190312]
  6. Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province
  7. Open Fund of the Department of Chemistry
  8. Qingdao University of Science and Technology [QUSTHX202010]

向作者/读者索取更多资源

Molecular electrophotocatalysis is a powerful strategy for sustainable synthesis, and has been applied in a versatile electrophotocatalytic deaminative alkylation approach. The key point lies in the in situ recycling of alkyl radicals, and the method has also been successfully applied in ligand modification and late-stage functionalization of pharmaceuticals.
Molecular electrophotocatalysis has emerged as a powerful strategy for the development of sustainable synthetic protocols. With the proof-of-concept, we exploited a versatile electrophotocatalytic deaminative alkylation approach. Mechanistic investigation indicated that in situ recycling of the alkyl radicals was the key point. Notably, ligand modification and late-stage functionalization of pharmaceuticals were also established, highlighting its feasibility in practical utilization.

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