期刊
ORGANIC LETTERS
卷 24, 期 18, 页码 3395-3400出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01166
关键词
-
Here, we report the Rh(III)-catalyzed C-H activation followed by redox-neutral [3 + 2] annulation of sulfoxonium ylides with 1,3-diynes, delivering alkynated indenone derivatives. This method shows a broad substrate scope, good functional group tolerance, and mild reaction conditions.
The transition-metal-catalyzed C-H functionalization of sulfoxonium ylides with alkynes formally participates in [4 + 2] annulations to deliver the naphthol scaffolds. In contrast, herein we disclose the first Rh(III)-catalyzed C-H activation, followed by redox-neutral [3 + 2] annulation of sulfoxonium ylides with 1,3-diynes, which delivers the alkynated indenone derivatives. This protocol features a good functional group tolerance, a broad substrate scope, moderate to excellent yields, and mild reaction conditions. The reaction mechanism was supported through ESI-HRMS by characterizing key intermediates in the catalytic cycle.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据