期刊
ORGANIC LETTERS
卷 24, 期 14, 页码 2590-2595出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00451
关键词
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资金
- National Natural Science Foundation of China [21871152, 92056105, 21790332]
- National Key R&D Program of China [2021YFA1500200]
- Haihe Laboratory of Sustainable Chemical Transformations
- Frontiers Sciences Center for New Organic Matter (Nankai University) [63181206]
This study reports a concise and efficient synthetic strategy for the rapid assembly of cis-fused octahydrophenanthrene scaffolds, resulting in the construction of compounds with an arylated all-carbon quaternary stereocenter.
A three-step process for the enantioselectiveassembly ofcis-fused octahydrophenanthrenes with a quaternarystereocenter is reported. This synthetic strategy relies on aregioselective gamma-alkylation, a one-pot sequence of asymmetrichydrogenation and oxidation, and an intramolecular enolatearylation to facilitate the rapid and enantioselective constructionofcis-fused octahydrophenanthrene scaffolds with an arylated all-carbon quaternary stereocenter concisely and efficiently.
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