Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as thecatalyst. This original reaction is highly tolerant to various glutarimideamides as well as organozinc coupling partners. These conditions alsoallow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.

Automated summary

A novel Negishi-type cross-coupling reaction using only cobalt bromide salt as the catalyst is described in this study. This original reaction demonstrates high tolerance to various glutarimide amides and organozinc coupling partners. Additionally, the reaction can be performed on a large scale using an eco-compatible solvent such as ethyl acetate.