Role of p38 MAP kinase in cancer stem cells and metastasis

Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer stem cells (CSCs) underlie treatment resistance and metastasis. p38 mitogen-activated protein kinase (p38 MAPK) is downstream of several CSC-specific signaling pathways, and it plays an important role in CSC development and maintenance and contributes to metastasis and chemoresistance. Therefore, the development of therapeutic approaches targeting p38 can sensitize tumors to chemotherapy and prevent metastatic progression.

Automated summary

Therapeutic resistance and metastatic progression are the main causes of cancer deaths, with cancer stem cells (CSCs) playing a crucial role in these processes. p38 MAPK is important for CSC development and maintenance, and its targeting can enhance chemotherapy sensitivity and prevent metastatic progression.