4.8 Article

Copy number amplification and SP1-activated lncRNA MELTF-AS1 regulates tumorigenesis by driving phase separation of YBX1 to activate ANXA8 in non-small cell lung cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

RNA contributions to the form and function of biomolecular condensates

Christine Roden et al.

Summary: Recent studies have shown the significant contribution of RNA to cellular liquid-liquid phase separation and condensate formation, which play important roles in various cellular functions such as RNA transport, supporting catalytic processes, and stress responses. Although RNA and RNA-protein condensates are important in cells, the role of RNA in liquid-liquid phase separation has received less attention in comparison to RNA-binding proteins.Properties such as composition, length, structure, modifications, and expression levels of RNA can modulate the biophysical features of native condensates, influencing their size, shape, viscosity, and composition. RNA-protein condensates are involved in various cellular functions, including cell compartmentalization through RNA transport and localization, supporting catalytic processes, storage and inheritance of specific molecules, as well as buffering noise and responding to stress.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Biomolecular Condensates and Cancer

Ann Boija et al.

Summary: Biomolecular condensates, membraneless bodies formed by liquid-liquid phase separation, compartmentalize specific proteins and RNA molecules. Recent studies have revealed their potential roles in oncogenesis and influence on cancer therapeutics.

CANCER CELL (2021)

Article Multidisciplinary Sciences

lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription

Man Wu et al.

Summary: In this study, it was found that individual spherical FC/DFC units in human cells are coated by DDX21, and the long noncoding RNA SLERT promotes DDX21 to adopt a closed conformation and form loose clusters, impacting ribosomal RNA production.

SCIENCE (2021)

Article Medicine, Research & Experimental

LINC00665 Induces Acquired Resistance to Gefitinib through Recruiting EZH2 and Activating PI3K/AKT Pathway in NSCLC

Xinyin Liu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Genetics & Heredity

Liquid–Liquid Phase Separation in Disease

Simon Alberti et al.

Annual Review of Genetics (2019)

Article Multidisciplinary Sciences

Coactivator condensation at super-enhancers links phase separation and gene control

Benjamin R. Sabari et al.

SCIENCE (2018)

Review Cell Biology

Long Noncoding RNA in Cancer: Wiring Signaling Circuitry

Chunru Lin et al.

TRENDS IN CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

Mathias Munschauer et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1

Erbao Zhang et al.

GENOME BIOLOGY (2018)

Review Cell Biology

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Medicine, Research & Experimental

cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

Zirong Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

Hani Goodarzi et al.

Review Cell Biology

Y-box binding protein 1-A prognostic marker and target in tumour therapy

Corinna Kosnopfel et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Involvement of annexin A8 in the properties of pancreatic cancer

Harumi Hata et al.

MOLECULAR CARCINOGENESIS (2014)

Article Multidisciplinary Sciences

PVT1 dependence in cancer with MYC copy-number increase

Yuen-Yi Tseng et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

Pedro J. Batista et al.

Review Biochemistry & Molecular Biology

lincRNAs: Genomics, Evolution, and Mechanisms

Igor Ulitsky et al.

Article Multidisciplinary Sciences

Landscape of transcription in human cells

Sarah Djebali et al.

NATURE (2012)

Review Genetics & Heredity

Non-coding RNAs in human disease

Manel Esteller

NATURE REVIEWS GENETICS (2011)

Review Oncology

The Emergence of lncRNAs in Cancer Biology

John R. Prensner et al.

CANCER DISCOVERY (2011)

Article Anatomy & Morphology

The role of Sp1 and Sp3 in normal and cancer cell biology

Lin Li et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2010)

Article Multidisciplinary Sciences

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim et al.

NATURE (2010)

Review Oncology

Importance of Quality of Life in Patients with Non-Small-Cell Lung Cancer

Carlos Camps et al.

CLINICAL LUNG CANCER (2009)

Review Genetics & Heredity

Long non-coding RNAs: insights into functions

Tim R. Mercer et al.

NATURE REVIEWS GENETICS (2009)

Review Biochemistry & Molecular Biology

Sp1: Emerging roles - Beyond constitutive activation of TATA-less housekeeping genes

Inken Wierstra

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemistry & Molecular Biology

DNA copy number gains in head and neck squamous cell carcinoma

M Lin et al.

ONCOGENE (2006)