Current Status of Metabolic/Bariatric Surgery in Type 1 Diabetes Mellitus: an Updated Systematic Review and Meta-analysis

This systematic review and meta-analysis intend to evaluate the efficacy of metabolic/bariatric surgeries (MBS) in patients with type-1 diabetes mellitus. A systematic literature search and meta-analysis were performed in electronic databases up to July 2021. In total, 27 primary studies comprising 648 subjects were included in this systematic review and meta-analysis. Patients had a mean age of 38.0 +/- 7.3 years. Preoperative mean BMI was 42.6 +/- 4.7 kg/m(2) and 29.4 +/- 4.7 kg/m(2) after surgery, respectively. Following bariatric surgeries in patients with type 1 diabetes mellitus, insulin (unit/day) decreased by a weighted mean difference (WMD) of - 10.59. Also, insulin (unit/kg/day) decreased by a WMD of - 0.2, and HbA1C decreased by a WMD of - 0.71, showing MBS acceptable and durable effects of bariatric surgical procedures.

Automated summary

This study systematically reviewed and conducted a meta-analysis to evaluate the efficacy of metabolic/bariatric surgeries in patients with type 1 diabetes mellitus. The results showed that these surgeries had significant effects on insulin and glycemic control.